Endocrine Abstracts

AROM+ mice express universally the human P450 aromatase enzyme, leading to increased serum and intratesticular E2/T ratio. AROM+ mice are infertile and present with testicular inflammation characterized by a high amount of macrophages, mast cells and fibrosis. Interestingly, testis macrophage and mast cell infiltration together with fibrosis has also been connected to infertility in men. The aim of the study was to find out whether there are similar changes at the molecular le...

Objective: To investigate frequency of secondary GH deficit (SGHD) in patients with acromegaly in the Republic of Uzbekistan (RUz).Material and methods: There are 366 patients with acromegaly registered in RUz. We observed 15 patients with acromegaly with SGHD, among them 3 male and 12 female with middle age 51.6 years. All patients undergone following tests: pituitary hormones levels (GH, IGF1, ACTH, prolactin, TSH, FSH, LH, etc.), blood glucose, bioche...

Two identical twins aged 20 were referred for investigation and treatment of delayed puberty. They were otherwise fit and well, with no significant past medical history. On presentation, both were tall, eunuchoid with no secondary sexual characteristics. Twin A had undergone orchidopexy for an undescended testicle, but had a normal sense of smell on testing. Twin B had normal pre-pubertal external genitalia, but reported anosmia. Neither exhibited synkinesis, abnormal dentitio...

The rising prevalence of type 2 diabetes can be directly related to increasing levels of population obesity and associated insulin resistance. Adipose tissue has neuroanatomically well characterized sympathetic innervation (with activation initiating lipid mobilization), but little evidence to support the presence of a (putatively counter-regulatory) parasympathetic input (Bartness & Song 2007). Parasympathetic actions are mediated through muscarinic acetylcholine receptor...

Neuroendocrine tumours are slow growing and could be mistaken for other more malignant tumours with poorer prognosis. Their secretory profile may alter with time. The importance of awareness of these tumours and their clinical behaviour is illustrated by the case of a 78-year-old woman who presented with recurrent fasting hypoglycaemia.The patient had been diagnosed with metastatic pancreatic adenocarcinoma a year previously on the basis of radiographic ...

We present the case of a 76 year old woman who was admitted to our hospital with severe Cushings syndrome, in association with hair loss and hypokalaemia. Plasma cortisol levels were elevated, and did not suppress with high dose dexamethasone. ACTH levels were detectable throughout the HDDST. MRI pituitary and CT adrenals were normal, but CT of chest revealed an area of nodularity in the right lung. With no specific treatment her symptoms settled, and her biochemistry returned...

Acromegaly causes various cardiovascular dysfunctions, and cardiovascular complications are the main cause of increased mortality in non-cured acromegalic patients. The aim of the study was assessment of flow mediated dilatation (FMD) and the concentration of soluble vascular cell adhesive molecule (sVCAM) as the selected markers of endothelial dysfunction in patients suffering from acromegaly. The study was carried out in 40 patients with acromegaly in various stages of the d...

Aim: To study physical, sexual and mental development and neurophychological disorders of children with congenital hypothyroidism.Methods and materials: 11.5±0.5 year old 60 children and teenagers with congenital hypothyroidism (CH) have been examined. Radioimmunologic (RIA) study of blood hormone level revealed confident decrease of somatotropic hormone (STH), thyroid (T3, T4), gonadotropic, sex hormones and increase of thyreotropic hormone (TTG). ...

Low-T3 syndrome (euthyroid sick syndrome) develops in critically ill patients. Due to the catabolic state, accompanying critical illnesses, enhanced oxidative damage to macromolecules is expected to occur in subjects suffering from the low-T3 syndrome.The study aimed at evaluating the level of lipid peroxidation products in blood serum, collected from critically ill patients with the low-T3 syndrome and at estimating the ...

Thyroid Hormones have extensive effects on differentiation, development, and growth of different organs. In this study the effect of the administration of PTU on pregnant and lactating rats on isolated aorta response of their adult offsprings has been investigated. Three groups of female rats were selected. In the first group (fetal group) observation of vaginal plug after mating was considered as the first day of pregnancy, then PTU was added to their drinking water until the...