Searchable abstracts of presentations at key conferences in endocrinology

ea0002p38 | Endocrine tumours and neoplasia | SFE2001

Effect of metallopeptidase inhibitors and growth factors on MCF-7 cell proliferation

Ahmed M , Schrey M , Parish D

Regulatory peptides are known to have a role in tumour growth. Local peptide concentrations will be affected by their proteolytic release from precursors, together with the rate of their proteolytic degradation. In this study three inhibitors of proteolysis were examined, Captopril, an ACE inhibitor, Thiorphan an inhibitor of Neutral Endopeptidase and Phosphoramidon which inhibits both Neutral Endopeptidase and also Endothelin Converting Enzyme (ECE). The effect of these inhib...

ea0054is7 | (1) | NuclearReceptors2018

Clinically-relevant contexts for AR variants in prostate cancer

Dehm Scott M

The androgen receptor (AR) functions as a master transcriptional regulator of prostate tissue homeostasis. This master transcriptional regulator function is maintained in prostate cancer. Therefore, prostate cancer is an androgen-dependent disease and suppression of AR transcriptional activity with androgen deprivation therapy (ADT) is an effective systemic therapy. However, development of therapy resistance and transition to castration resistant prostate cancer (CRPC) represe...

ea0081ap4 | Clinical Endocrinology Trust Award Lecture | ECE2022

Setting the scene for (rare) endocrine diseases in Europe

Pereira Alberto M

My research focuses on the long-term consequences of pituitary diseases, and on the effects of stress hormones on the central nervous system (CNS) in specific. This has elucidated long-term effects of hormone excess on the CNS, as well as on other organs that affect stress-resilience, and consequently, general well-being and quality of life. This profoundly affects our understanding of the biological effects of stress hormone excess on the CNS, and on the care for patients wit...

ea0083tp4 | Thyroid | EYES2022

Interplay between thyroid, amiodarone and heart - case presentation

M Mustapic , A Matijaca

Background: Amiodarone is a commonly used antiarrhythmic drug, but because of its abundance with iodine and a direct toxic effect on the thyroid, it can have side effects like hypo- and hyperthyroidism. There are two types of amiodarone-induced thyrotoxicosis (AIT). We present a case which demonstrates the importance of timely diagnosis and appropriate treatment of amiodarone-induced thyrotoxicosis in patients with serious cardiac comorbidities.Case Pres...

ea0090s20.1 | Update on consequences of long-term exposure/treatment with glucocorticoids | ECE2023

Impairment of the HPA axis after treatment with glucocorticoids

Stewart Paul M

1% of western populations take chronic oral corticosteroids and this rises to 3% in subjects aged over 70 years old. When inhaled, topical and parenteral steroids are added to this burden, iatrogenic Cushing’s becomes a major health issue. High doses of medroxyprogesterone acetate can cause glucocorticoid effects and drug interactions may impair the metabolism of some glucocorticoids (eg fluticasone), thereby increasing their potency. Patients may develop the classical fe...

ea0090s21.3 | The role of muscle in metabolic diseases | ECE2023

The role of exosomes in clinical aspects of metabolic disease

Falcon-Perez Juan M

Extracellular vesicles (EVs) constitute a novel biological entity to identify biomarkers, and as active players in the development of liver diseases. Omics technologies have been widely applied to characterize the content and function of EVs secreted by liver cells in different pathological scenarios including drug-induced liver injury (DILI), NAFLD and metabolic syndrome. Thus, transcriptomics and proteomics of these EVs have provided several low invasive candidate biomarkers...

ea0066oc7.5 | Oral Communications 7 | BSPED2019

Medication adherence during adjunct therapy with statins and ACE inhibitors in adolescents with type 1 diabetes

Marcovecchio M Loredana

Background: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes (T1D). However, to date, there are no available data on adherence to adjunct non-insulin medications in this population. The aims of this study were to assess adherence to ACE inhibitors and statins and explore potential determinants in adolescents with T1D in the context of a clinical trial.Methods: 443 adolescents (aged 10–16 years) were recru...

ea0062p42 | Poster Presentations | EU2019

Severe hypercalcaemia in a young patient

Lin NT , Thomas M

Case History: 16-year-old fit and well lady was referred to endocrinology clinic by GP due to severe hypercalcaemia. She is being investigated for secondary amenorrhea. She is not taking any regular medication. There is a history of hypercalcaemia in the family, her mother has hypercalcaemia and paternal grandfather had hypercalcaemia. She had no signs and symptoms of hypercalcaemia.Investigations: Corrected Calcium: 3.28 mmol/l, Phosphate: 0.60 mmol/l, ...

ea0063cet1 | Clinical Endocrinology Trust Lecture | ECE2019

How can patients’ perception of outcome be improved after controlling pituitary disease?

Webb Prof Susan M

As endocrinologists, we consider a patient with a pituitary disease is controlled if hormone parameters are normalized and tumour growth is stabilized. However, the patients’ perception of health is related to whether they can continue performing their daily life, both personal and professional; this is often not the case due to pain, physical or psychological limitations or social/family issues related to their disease. This is more relevant nowadays that pituitary dysfu...

ea0063s11.3 | EDCs & reproduction | ECE2019

Mitigating against endocrine disruption in pregnancy

Main Katharina M

Three decades ago wildlife findings of intersex, malformations and sex ratio changes in marine species, birds and mammals could be associated to environmental pollution. Public concern arose as to whether this was also a threat to humans as many countries experience an increase i.e. in the prevalence of infertility and obesity. Humans are continuously exposed to small doses of hundreds of EDCs throughout life and we know very little about their combined effects. Over the past ...