Endocrine Abstracts

Background: Diabetic ketoacidosis (DKA) is the most serious acute metabolic complications of diabetes. Unfortunately, there is a dearth of published data on this entity from Egypt. The aim of our work was to determine the clinical characteristics, precipitating causes and mortality rate of patients with diabetic ketoacidosis in National Institute of Diabetes and Endocrinology.Methods: Our work is a retrospective study in which we reviewed and analyzed th...

Background: Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO3] and pH) and qualitative nature (the presence of ketonemia/ketonuria). A new method is now available to measure capillary levels of beta-hydroxybutyrate (beta -0HB), It is a quantitative and enzymatic test that uses the same equipment as for home capillary blood glucose determination but with specific strips. Aim of the work: The aim of thi...

Introduction: Prevalence of diabetic neuropathy is between 10 to 90% in different studies base on the method of it evaluation(clinical or paraclinical).Objective: Evaluation of frequency of diabetic polyneuropathy indiabetic persons in endocrinology clinic of mashad endocrinand metabolic research center based on symptoms,signs and electrodiagnostic study.Method: The study was cross-sectional; 110 diabetic patients were enrolled.pat...

Diabetic ketoacodosis (DKA) is a serious complication of diabetes mellitus, especially type 1, and its secondary consequences account for a large proportion of diabetes-related hospitalizations and mortality in children with type 1 diabetes.Aim of the work: The aim of this study was to compare between the outcomes of application of ISPAD (International Society of Pediatric & Adolescence Diabetes) versus ADA, (American Diabetes Association) guidelines...

Background: Diabetic ketoacidosis (DKA) is a life-threatening condition that requires hospitalization in children with type 1 diabetes. Many reports have indicated that low-dose insulin therapy is quite effective regardless of the route of administration, whether, intramuscular, or subcutaneous.Aim of the work: The aim of this study was to look for technical simplification and economic efficiency in the treatment of diabetic ketoacidosis (DKA) with subcu...

Objective: To describe a patient with an unusual course of primary hyperparathyroidism (PHPT) due to parathyroid adenoma in 2004, who developed recurrent hyperparathyroidism due to parathyroid carcinoma in 2010, and a subsequent adenoma in 2011.To our knowledge, this sequential occurrence has not been previously reported in literature.Case: A 57-year old male was operated on for a parathyroid adenoma in the right inferior gland in 2004. He was asymptomat...

Background: A number of studies have evaluated the association between prolactin (PRL) and breast cancer risk, but some results have been inconsistent.The aim of this study was to investigate, if the circadian rhythm of PRL was maintained in pre- and post-menopausal patients with breast cancer and if there is a correlation between serum PRL level, serum concentration of insulin-like growth factor 1 (IGF1), tumor staging and expression of estrogen, proges...

Numerous studies provided data on possible decline in human fertility over the last decades and geografic differences in it. So, recently research interest in these tendencies and possible factors affecting fertility is increased.Objective: In this study, we aimed to explore women’s fertility expressed as time to pregnancy (TTP) – the number of contraceptive-free cycles needed to conceive – in a large cohort of Lithuanian women and the eff...

In pigs, the assembly of primordial follicles and their subsequent transition to the primary stage occur in the late gestational and neonatal period. Previously, we reported the presence of androgen receptors in the porcine fetal ovary on different days of gestation, which suggests a fetus capacity to respond to androgens. Since testosterone was detected in the plasma of porcine female fetuses during the second half of pregnancy, it is possible that androgens are involved in p...

Infertility affects 1 in 20 Australia men of reproductive age, and for the majority, the causes remain unknown. In an effort to identify addition key pathways and proteins involved in male fertility we undertook a random mouse mutagenesis screen. In the process we identified the Mot1 line which carries a point mutation in the Rabl2 gene. Mot1 homozygous male are sterile, have a reduced daily sperm output, short sperm tails and drastically reduced progressive sperm motil...