Endocrine Abstracts

It is generally accepted that hepatic responses to α-adrenergic agonists are dependent on the redistribution of intracellular and also extracellular Ca2+. Besides, phenylephrine induces significant K+ flux changes and plasma membrane hyperpolarisation. Earlier it was shown that K+ channel blockers as well as chelating of extracellular Ca2+ with EGTA could inhibit phenylephrine-induced metabolic responses and activation of mitoch...

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a cluster...

We assessed glycemic status using oral glucose tolerance, 72-h continuous blood glucose concentrations by CGMS, calculate HOMA and QUICKI indices.Population: 15 adolescents with β thalassemia major.Results: Oral glucose tolerance test (OGTT) In the 15 thalassemic adolescents (age=19.75±3.08 years) showed that four had impaired fasting blood glucose level (IFG)>5.6 mmol/l. One of them had diabetes (BG=16.2 mmol/l at 2-...

It has been reported that orexins play an important role in the regulation of GH secretion. It is suggested that the defect in orexins synthesis could be responsible for the disturbances in GH synthesis and consequently aggravate metabolic disturbances. The aim of the study was to assess plasma orexin A levels in patients with acromegaly in relation to the activity of disease and hormonal and metabolic profiles. Fifty-five patients with acromegaly divided into three groups acc...

We conducted this study to determine the degree of obesity influence on the hypoglycemic response of growth hormone and cortisol after weight loss of 5%. A total of 45 non-diabetic, male subjects followed in the outpatient endocrinological department were divided into three groups comprising 15 subjects in each group, based upon body mass index (BMI) to healthy, overweight and obese group. Metformin was administered in the dose of 500 mg daily to the overweight and obese parti...

Objective: It is known sex steroids affect fat distribution with men and women. With men there is a tendency to deposit fat abdominally. Men are more likely to have more visceral fat than premenopausal women, with whom the preferential fat distribution is gluteofemoral and the percentage of body fat overall higher. Androgens may affect fat tissue with men either directly by androgen receptor stimulation, or indirectly by oestrogen receptor stimulation after aromatization. Inte...

Although neuroactive steroids are well characterized, their physiological relevance in human pregnancy remains indecisive. Hence, we attempted to derive this information from the combination of our metabolomic data, pharmacological data found in the literature and knowledge contained in gene expression databases. These results indicate that GABAergic steroids influence maternal CNS but have limited effect in the fetal brain and maternal and fetal periphery, partly because of t...

Chronic lymphocytic thyroiditis, also known as Hashimoto thyroiditis, is the most frequent type of thyroiditis. An average 2% of the population suffer from the disease. The incidence of the disease is estimated as 0.3–1.5/1000 people a year.The main cause of the disease includes autoimmune disorders, that result in increased risk of diabetes type 1. Furthermore, during the course of Hashimoto thyroiditis, hypothyroidism may originate carbohydrate me...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism. Material and methods: We treated 950 patients, aged 30–70 years; 87% of them were female and 13% male; 320 patients with multinodular goitre (MNG), and 630 patients with autonomous nodule (ATN). Some of the patients were treated with antithyroid drugs for 1 to...

Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves’ ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor-β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO.Methods: The following ...