Endocrine Abstracts

Ventricular tachycardia may occur in the setting of primary hyperthyroidism despite the absence of typical hyperthyroid symptoms. The case is a 40-year old female coming in for epigastric pain and vomiting who was incidentally found to have monomorphic ventricular tachycardia. Despite this she was in no respiratory distress, and exhibited no symptoms of heart failure. Other than agitation, physical examination showed no signs of hyperthyroidism. Initial management included num...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...

Cardiomyopathy can occur due to hypothyroidism or hypocalcemia but often resolves with judicious treatment with levothyroxine and correcting calcium levels to acceptable levels. We discuss a case of a 37-year-old woman presenting with acute cardiogenic shock and a history of total thyroidectomy 6 years prior for papillary thyroid carcinoma stage 1 (T2N1aM0). Patient was non-compliant to levothyroxine treatment and developed easy fatigability and exertional dyspnea 5 months bef...

Up till now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells that have been classified as a new lineage, distinct from Th1, Th2 and Treg cells. Despite wide interest, role of Th17 cells in the pathogenesis of inflammatory and autoimmune diseases is still debated. Th17 cells are involved ...

Introduction: Iodine deficiency is a common problem of public health that usually causes thyroid enlargement called goiter. It is estimated that 750 million people worldwide are at risk of Iodine Deficiency Disorders (IDD). IDD can be presented with a wide variety of clinical manifestations, which induce congenital anomalies, cretinism, deaf mutism, psychomotor defects and severe goiter.About 17 years after the initiation of salt iodization in Iran, this...

Background: Recent reports have mentioned rising incidence of thyroid cancer (TC) detected before and after thyroidec-tomy (Tx) for hyperthyroidism but “hyperfunctioning” TC is however a rare entity.Patients & Methods: Among a personal series of 464 patients which underwent Tx including 147 (33.6%) cases of thyroto-xicosis and 72 (13.6%) cases of TC, we founded 10 patients with hyperthyroidism and nodular or microscopic TC but only one case...

A 68 years old lady was referred to our endocrine clinic after she had routine blood tests done as a part of monitoring of her chronic kidney disease stage 3. She had high corrected calcium of 2.85 mmol/l and parathyroid hormone levels of 13 pmol/l consistent with primary hyperparathyroidism. She was clinically symptomatic with high calcium and had polyuria, polydipsia and constipation. There was no history of renal calculi or fractures although DEXA scan confirmed osteoporosi...

In type 1 diabetes mellitus the insulin-secreting β-cells in pancreatic islets of Langerhans are selectively destroyed by autoimmune assault. Since diabetes is caused by the loss of a single cell type it is amenable to treatment by cell replacement therapy. Advances in islet transplantation procedures have demonstrated that people with type 1 diabetes can be cured by human islet transplantation, but the severely limited availability of donor islets has restricted the wide...

Case history: We report 7 weeks old with central diabetes insipidus, holoprosencephaly (HPE), immunodeficiency and severe colitis. She was first admitted with severe diarrhoea and hypernatremia. A diagnosis of central diabetes insipidus (CDI) was made and she was commenced on subcutaneous desmopressin (DDAVP). Her initial hypothalamic–pituitary axis (HPA) was normal (ACTH 10 ng/l, cortisol 635 nmol/l, GH 23 μg/l and TSH 3.30 μ/l). However repeated cortisols and ...

Abstract unavailable....