Endocrine Abstracts

Introduction: Patients with Addison’s disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD disease-specific quality of life questionnaire (AddiQoL) was developed to aid evaluation of patients. We here aimed to validate translated questionnaires in terms of internal consistency and reliability and to improve the construct of the scale.Methods: After translation by a multistep approach, the final versions were...

Non-alcoholic fatty liver disease (NAFLD), currently considered a major problem of public health, includes fatty liver alone, steatohepatitis, fibrosis, cirrhosis. Obesity increases the risk of NAFLD in the patients having BMI >30 kg/m2, where the liver involvement is a common aspect.Aim: To find non-invasive methods fro the selection of patients with risk of progression of liver disease.Materials and methods: We sel...

Introduction: Cellular differentiation and development of germ cells critically depend on a coordinated activation and repression of specific genes. The underlying regulation mechanisms, however, are largely unknown. Here, we describe the interplay between two transcription factors to be critical for cell type-specific expression in testis.Methods: We investigated the binding of CREMτ (cAMP response element modulator tau) and GCNF (germ cell nuclear...

Background: Testosterone substitution with favourable kinetics and tolerance is important for hypogonadal men. Intramuscular injections of long-acting testosterone undecanoate (TU) offer a convenient modality.Methods: We report data from 281 patients (134 with primary, 88 with secondary hypogonadism and 59 with late-onset (‘mixed’ or ‘metabolic’) hypogonadism aged 15 to 72 years (mean 40±13 years) receiving altogether 4913 intram...

Objective: To estimate the value of the questionnaire QoL – AGHDA, KIMS for revealing of GH deficiency (GHD) in adults for estimation of the condition of patients with various pituitary adenomas.Material and research methods: We examined 72 adult patients with pituitary adenomas and GHD from 2008 till 2009. From them there were 30 men (41.6%), and 42 women (58.3%). Middle age was 38.0 years.Research methods included: i) Clinic...

Aim of the research: To reveal neuroendocrine disorders rate in patients with different pituitary adenomas retrospectively.Patients and methods: We analyzed 81 patients records with different pituitary adenomas from 2000 to 2009. Of 81 patients 23 were men (28.4%) and 58 women (71.6%). Mean age of male patients was 37.2 years-old whereas in women this was 34.5 years-old.1st group of patients was with Cushing’s disease (CD) &#1...

Study objective: We investigated prevalence of impaired glucose homeostasis in a large cohort of adult patients with GH deficiency (GHD), not treated with GH after more than 10 years of follow-up.Design: Seventy-one adult GHD patients (30 males, 41 females; mean age 48.3±2.0 years, mean BMI 28.8±0.7 kg/m2, GH deficient for 10.2±1.2 years) were evaluated. Ninety percent of patients had multiple pituitary hormone deficiencies whic...

Giant prolactinomas are rare and their treatment and outcome has been addressed only in isolated case reports. Some patients develop treatment-resistant tumors. We describe a patient with an invasive PRLoma resistant to conventional therapy. A 40-year-old female was diagnosed at age 22 a PRLoma who, although having received all available formulations of dopamine agonists over a period of 18 years, responded neither clinically, nor hormonally (PRL 9560.0 ng/ml, nv <20). At ...

In acromegaly symptom control can be achieved by lowering insulin-like growth factor 1 (IGF1) concentrations to the age-adjusted normal range. However, even with optimal surgery and current medical therapies (dopamine agonists, somatostatin analogues), 30–50% of patients do not achieve target concentrations of IGF1 and GH. Pegvisomant (PEGV), a new GH-receptor antagonist, given as s.c. injections at variable dosages, could normalises IGF1 concentrations in ~70% of acromeg...

Body composition using dual energy X-ray absorptiometry (DEXA) can be used as an specific method for measuring fat mass and identify individual risk for cardiovascular and metabolic complications in obese children.Objective: To investigate serum leptin level and its relationship with fat distribution in obese children.Materials and methods: Eighty-seven children (male/female=43/44, mean age 12.81±0.5 years). obese (BMI>95 ...