Searchable abstracts of presentations at key conferences in endocrinology

ea0026p540 | Bone/calcium/Vitamin D | ECE2011

Comparison of oral versus intramuscular treatment of vitamin D deficiency or insufficiency

M Shahrivari

BACKGROUND: Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them. This clinical trial study was aimed to compare the efficacy of two different regimens of vitamin D supplements on serum 25(OH) D3 level, at the end of a 3 months therapy period. DESIGN: 84 cases of vitamin D deficiency or insufficiency who did not meet exclusion criteria were randomized to two different vitamin ...

ea0025cm3.1 | Pituitary radiotherapy: what are the options? | SFEBES2011

Focused radiotherapy as primary treatment for pituitary disease

Brada M

Fractionated radiotherapy (RT) is effective in achieving disease control and normalisation of hormone levels. While overall safe, it is not devoid of side effects and should only be employed when the risks from the disease are considered to outweigh the risks from treatment. Currently RT tends to be withheld until progression unless there is a threat to function, particularly vision, from progressive tumour. RT is recommended for patients with secreting adenoma not achieving b...

ea0024s8 | RCN CYP diabetes community session | BSPED2010

Regional networks and PBR

Hannigan M

There are 23 000 children with diabetes in England and managing diabetes in a child or young person can be a complex process. Historically care has been variable and the experience of the child or young person is not always positive. This situation has been compounded by a lack of a paediatric diabetes tariff and networks to support best practice.NHS Diabetes is supporting a number of new innovative projects to develop regional paediatric networks to sup...

ea0024s20 | Catherine Hall Memorial Lecture | BSPED2010

Catherine Hall Memorial Lecture: Congenital hyperinsulinism and DOPA-PET CT

Skae M

Congenital hyperinsulinism of infancy (CHI) is a rare disorder of insulin dysregulation, resulting in persistent hypoglycaemia and its sequelae. More than half of patients have loss-of-function mutations in ABCC8 or KCNJ11 genes encoding subunits of ATP-sensitive potassium (KATP) channels. Histologically, disease pathology is subdivided into diffuse or focal disease; the latter associated with paternal mutations and somatic loss of maternal heterozygos...

ea0024s21 | Symposium 3 – The Beta cell | BSPED2010

Altered beta-cell signalling and congenital hyperinsulinism of infancy (CHI)

Dunne M

Ion channels play a key role in the regulation of insulin release. Conveying the signals associated with glucose metabolism, ATP-sensitive potassium (KATP) channels induce a depolarisation of the cell membrane which in turn regulates Ca2+ influx and Ca-dependent exocytosis of insulin-containing granules. Congenital hyperinsulinism is caused by channelopathies through loss-of-function mutations in the genes which encode KATP channels (...

ea0021sb1.2 | How to access funds and revolutionise your research | SFEBES2009

Integration of live cell imaging and mathematical modelling: how to use systems biology to revolutionise your research

White M

The advent of high throughput techniques and genome sequencing has brought about a new era in the availability of biological data. This has created a need for new approached for data integration and to interpret complex biological data sets. A cell cannot be considered as using a set of independent signalling pathways. Instead, it is now clear that signalling proteins are integrated into a complex network. The human brain cannot handle this complexity. At the same time, we nee...

ea0021se1.5 | (1) | SFEBES2009

La Mujer Barbuda by Ribera, 1631: a clinical conundrum

Tunbridge M

The picture showing a markedly virilised central figure with an infant at the breast and a shadowy figure in the background was painted in 1631 by Jose Ribera, a Spaniard living in Naples. It was commissioned by Ribera’s patron, the Duke of Alcela. The painting is of a real named person. The provenance of the painting is well known and through the Duke’s family inheritance it returned to Spain and is to be seen in the Muse Fondacion Duque de Lerma in Toledo. It can a...