Endocrine Abstracts

Diabetes is associated with a greatly increased risk of cardiovascular disease and the advanced glycation end products (AGEs) and their receptors play an important role in these complications.Objective: To study the association between AGEs and sRAGE levels with cardiovascular risk factors in obese and non-obese newly diagnosed type 2 diabetic patients.Material and methods: We conducted a cross-sectional study in subjects with type...

In obesity the combined effects of enhanced food consumption, enhanced oxidative stress and inflammation could increase levels of advanced glycation end products (AGEs) and the action of their receptors.Objective: To study circulating levels of AGEs, soluble RAGE and AGER-1 and their association with insulin resistance and inflammation in young subjects with obesity and normal weight.Material and methods: We conducted a cross-secti...

Context: Type 2 diabetes (T2D) is associated with an increased incidence of infections and several cancers. Although low-grade inflammation and certain immune defects have been found in diabetic patients, the role of adaptive immune response remains to be fully elucidated.Objective: We aimed to explore whether patients with T2D show defects in the activation of T cells.Design: Immune cell phenotypes, T cell functional reactivity, s...

Introduction: Obesity is defined as a chronic disease by AACE/ACE. Includes presence/severity of complications. VLCD diets induce relevant weight loss by improving these complications. PA is a bioelectric measure of the cell mass and it is marker a global prognostic factor of cellular functionalism.Methods: Case-control retrospective study of severe obesity in a weight loss program comparing intensive intervention (41 cases, VLCD 800 kcal/d, 1g protein/k...

Acromegaly is a rare disease, caused by an excessive secretion of growth hormone (GH), and consequently the insulin like growth factor 1 (IGF-1). Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone. It is known that use of FRAX in acromegaly is not validated, however we do not have other useful tools to assess real risk for fractures. The new valuable tool in the assessment of bone structure is the trabecula...

Introduction: The National Osteoporosis Guideline Group (NOGG) recommends determine BMD in patients who present an intermediate risk of osteoporotic fracture using the FRAX® tool, follow-up for low risk, and treatment for high risk. In 2011, 3163 BMD were performed in the Complejo Asistencial Universitario de León (CAULE). Since the cost for each BMD is 58.6* (BOCYL 31/01/2011), annual spending could rise to *185 352. The aim was to assess whether fracture risk calcu...

Introduction: Intraoperative parathyroid hormone assay (ioPTH) has been validated as a useful tool for predicting postoperative hypocalcaemia (hypoCa) after thyroid surgery and has been proposed as a guide to early discharge from hospital. Its value to predict the risk of future hypoparathyroidism (hypoPT) has not been analyzed in detail. We evaluate this role in our recent surgical series.Description of methods/design: Patients with total thyroidectomy ...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...

Aim: To investigate the ralationship between semen parameters and serum follicale-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin (PRL) in a group of Chinese men with congenital absence of vas deferens (CAVD).Methods: Ninety patients with CAVD were investigated. During the physical examination the body hair distribution, testicular size, epididymides and vas deferens were carefully inspected and palpated. Semen analysis i...

Introduction: The treatment of differentiated thyroid carcinoma exposes most patients to chronic supraphysiological doses of thyroid hormone which seems to have several negative effects for the patient. The goal of the present study was to assess the consequences of these doses on the bone mineral density (BMD).Patients and methods: We performed a cross-sectional study on 64 female patients followed up between 1972 and 2007. We registered the levothyroxi...