Endocrine Abstracts

Diabetes mellitus is currently being recognised as a global health problem. The likelihood of periodontal disease among diabetics is thrice and progresses rapidly when uncontrolled. Diabetics were less likely to see a dentist than to seek consult with a doctor for diabetes care. A cheap and easy way of clinical assessment via self-reported oral health questionnaire would be of great use especially in a developing country like The Philippines. This study aims to validate self-r...

Introduction: We wanted to analyse the pathology results of thyroidectomies performed in the hospitals of Castilla La Mancha (Spain) between the years 2010 and 2013, inclusive.Material and methods: A retrospective, multicentre, descriptive study of the histopathological results of the 1567 thyroidectomies performed in the hospitals of the eight health districts in our region between the years 2010 and 2013.Results: The histopatholo...

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...

Introduction: Retrospective study of patients undergoing thyroid surgery at the Hospital Virgen de la Luz, Cuenca (Spain) during the years 2010–2013.Material and methods: We evaluated data of 92 patients basically with nodular thyroid disease, who were studied and treated in our hospital.Results: Our series is made up of 92 patients (25% men and 75% women) with an average age of 52 years. The most common form of presentation (...

Introduction: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterised by ACTH resistance and isolated glucocorticoid deficiency. Mutations of ACTH receptor, known as melanocortin-2 receptor (MC2R), and melanocortin-2 receptor accessory protein (MRAP) account for approximately 25 and 15 to 20% of cases respectively. To date there is no strong evidence that heterozygous carriers have abnormal cortisol secretion.Case: We...

Liquorice is a sweetener found in many food products, soft drinks, snacks and herbal medicines. Liquorice ingestion is an uncommon cause of AME or pseudohyperaldosteronisim. The mechanism involves the inhibition of 11-beta-hydroxysteroid dehydrogenase type-2 by the active ingredient called glycyrrhizin, which leads to the uninhibited activation of mineralocorticoid receptors by cortisol. Confectionary products that contain liquorice are readily available in the European Union....

Adipokines belong to a group of proteins involved in the pathogenesis and progression of immune/inflammatory diseases. It is an open question whether and how adipokines contribute to these diseases. Adiponectin might be a key regulator of the immune system, playing a role in the progression of inflammatory disorders. Omentin has been recognized as an anti-inflammatory adipokine with influence on immune response regulation and inflammation, Systemic sclerosis (SSc) is a chronic...

A 35 year-old lady presented to her local hospital with a 3 year history of fatigue, weight gain, recurrent tonsillitis and oligomenorrhoea. Examination revealed facial plethora, round facies and thin skin on the dorsum of the hand. She appeared tanned, with evidence of spontaneous bruising and difficulty standing up from a chair unaided. No striae were present. Blood pressure was 152/91 mmHg. Investigations revealed a 0900 h cortisol of 632 nmol/l (ACTH 59 ng/l) and an elevat...

Introduction: The possible clinical impact of subclinical thyroid dysfunction on patients with cardiovascular events is important if one considers the high incidence of a mildly altered thyroid hormone pattern in this population. This study aims to determine the prevalence of subclinical thyroid dysfunction among patients presenting with cardiovascular events in Philippine General Hospital, and its impact on mortality.Methodology: A cross sectional, pros...

Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GH–IGF–IGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...