Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep89 | Adrenal and Cardiovascular Endocrinology | ECE2020

Apparent mineralocorticoid excess (AME): Finding the “root” cause

Kyithar Ma Pyeh , Blasiak Tomasz , Kodandapani Srinivasachar , Kumari Meena , McHugh Joseph

Liquorice is a sweetener found in many food products, soft drinks, snacks and herbal medicines. Liquorice ingestion is an uncommon cause of AME or pseudohyperaldosteronisim. The mechanism involves the inhibition of 11-beta-hydroxysteroid dehydrogenase type-2 by the active ingredient called glycyrrhizin, which leads to the uninhibited activation of mineralocorticoid receptors by cortisol. Confectionary products that contain liquorice are readily available in the European Union....

ea0070aep428 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adiponectin and omentin-1 concentrations in patients with systemic sclerosis

Bik Wojciech , Dopytalska Klaudia , Kalisz Małgorzata , Litwinuk Anna , Baranowska-Bik Agnieszka , Walecka-Herniczek Irena

Adipokines belong to a group of proteins involved in the pathogenesis and progression of immune/inflammatory diseases. It is an open question whether and how adipokines contribute to these diseases. Adiponectin might be a key regulator of the immune system, playing a role in the progression of inflammatory disorders. Omentin has been recognized as an anti-inflammatory adipokine with influence on immune response regulation and inflammation, Systemic sclerosis (SSc) is a chronic...

ea0070aep641 | Pituitary and Neuroendocrinology | ECE2020

Medical treatment leading to remission of ectopic cushing’s syndrome

Seguna Desiree , Shiafkou Marianna , Sahdev Anju , Al-Mrayat Ma’en , Akker Scott

A 35 year-old lady presented to her local hospital with a 3 year history of fatigue, weight gain, recurrent tonsillitis and oligomenorrhoea. Examination revealed facial plethora, round facies and thin skin on the dorsum of the hand. She appeared tanned, with evidence of spontaneous bruising and difficulty standing up from a chair unaided. No striae were present. Blood pressure was 152/91 mmHg. Investigations revealed a 0900 h cortisol of 632 nmol/l (ACTH 59 ng/l) and an elevat...

ea0032p197 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Impact of subclinical thyroid dysfunction on mortality among patients presenting with cardiovascular events

Nacpil Paulette , Arkoncel Ma Luisa , Ryan Ardena Gregory Joseph , Jimeno Cecilia

Introduction: The possible clinical impact of subclinical thyroid dysfunction on patients with cardiovascular events is important if one considers the high incidence of a mildly altered thyroid hormone pattern in this population. This study aims to determine the prevalence of subclinical thyroid dysfunction among patients presenting with cardiovascular events in Philippine General Hospital, and its impact on mortality.Methodology: A cross sectional, pros...

ea0032p464 | Diabetes | ECE2013

Effects of human insulin and insulin aspart preparations on levels of IGFI, IGFBPs and IGFI bioactivity in patients with type 1 diabetes

Ma Zhulin , Christiansen Jens Sandahl , Lauritzen Torsten , Parkner Tina , Laursen Torben , Frystyk Jan

Introduction: Type 1 diabetes (T1D) is characterized by primary insulin insufficiency and secondary disruption of GH–IGF–IGFBP axis. S.c. insulin therapy is necessary to normalize this axis. This study aimed to investigate whether the distinct insulin profiles obtained with insulin aspart and human insulin preparations, respectively, affect IGF1 concentration and bioactivity and IGFBP levels differently.Methods: In a randomized, four-period cro...

ea0029p140 | Bone & Osteoporosis | ICEECE2012

Teriparatide: effects on cortical bone microstructure

Stepan J. , Dobnig H. , Fahrleitner-Pammer A. , Ma Y. , Zeng Q. , Wan X. , Marin F. , Pavo I.

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

ea0029p723 | Diabetes | ICEECE2012

A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50 and human insulin: a randomized, quadruple crossover study

Ma Z. , Parkner T. , Frystyk J. , Laursen T. , Lauritzen T. , Christiansen J.

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

ea0029p1082 | Neuroendocrinology | ICEECE2012

Comparison of Chinese herbal mixture and electro-acupuncture on regulating endocrine disturbances and hypothalamic androgen receptor in rats with DHT-induced PCOS

Xu T. , Song L. , Li X. , Ma S. , Li L. , Feng Y.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting reproductive women. Treatments with Chinese herbal mixtures (HM) and electro-acupuncture (EA) have been proven efficient in clinic. This study evaluated the peripheral and central effects of HM and EA in dihydrotestosterone (DHT)-induced PCOS rats. The female Wistar rats were divided into control (C), control with placebo (CP), DHT-induced PCOS model (PCOS), PCOS model exposed to herbal mi...

ea0029p1642 | Thyroid (non-cancer) | ICEECE2012

Determinants of children’s iodine nutrition and epidemiological features of children’s goiter and nodule in iodine-excessive areas

Lv S. , Xu D. , Wang Y. , Du Y. , Jia L. , Chong Z. , Ma J. , Zhao J.

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

ea0019oc28 | Bone and Calcium | SFEBES2009

Novel Glial Cells Missing B (GCMB) mutations (Arg39Stop and Arg110Trp) that result in loss of subcellular localization and DNA binding, respectively, are associated with autosomal recessive hypoparathyroidism

Bowl MR , Mirczuk S , Cranston T , Bahl S , Allgrove J , Nesbit MA , Thakker RV

GCMB, which is the mammalian homologue of the Drosophila gene Glial cells missing, encodes a 506 amino acid parathyroid-specific transcription factor that contains: a GCM DNA-binding domain at residues 19–176; a predicted nuclear localization signal (NLS) at residues 176–193; an inhibitory domain at residues 258–347; and two transactivation domains at residues 174–263, and residues 428–506. To date only six different GCMB mu...