Searchable abstracts of presentations at key conferences in endocrinology

ea0029p140 | Bone & Osteoporosis | ICEECE2012

Teriparatide: effects on cortical bone microstructure

Stepan J. , Dobnig H. , Fahrleitner-Pammer A. , Ma Y. , Zeng Q. , Wan X. , Marin F. , Pavo I.

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

ea0029p723 | Diabetes | ICEECE2012

A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50 and human insulin: a randomized, quadruple crossover study

Ma Z. , Parkner T. , Frystyk J. , Laursen T. , Lauritzen T. , Christiansen J.

Aims: To compare the pharmacokinetic and pharmacodynamic profiles of insulin aspart, biphasic insulin aspart 70 (BIAsp70), biphasic insulin aspart 50 (BIAsp50) and soluble human insulin under experimental conditions.Methods: In this randomised, four-period crossover study, 19 type 1 diabetic patients received subcutaneous injections of identical doses (0.2 U/kg) of either insulin aspart, BIAsp70, or BIAsp50 immediately before a standardized meal, or huma...

ea0029p1082 | Neuroendocrinology | ICEECE2012

Comparison of Chinese herbal mixture and electro-acupuncture on regulating endocrine disturbances and hypothalamic androgen receptor in rats with DHT-induced PCOS

Xu T. , Song L. , Li X. , Ma S. , Li L. , Feng Y.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting reproductive women. Treatments with Chinese herbal mixtures (HM) and electro-acupuncture (EA) have been proven efficient in clinic. This study evaluated the peripheral and central effects of HM and EA in dihydrotestosterone (DHT)-induced PCOS rats. The female Wistar rats were divided into control (C), control with placebo (CP), DHT-induced PCOS model (PCOS), PCOS model exposed to herbal mi...

ea0029p1642 | Thyroid (non-cancer) | ICEECE2012

Determinants of children’s iodine nutrition and epidemiological features of children’s goiter and nodule in iodine-excessive areas

Lv S. , Xu D. , Wang Y. , Du Y. , Jia L. , Chong Z. , Ma J. , Zhao J.

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

ea0019oc28 | Bone and Calcium | SFEBES2009

Novel Glial Cells Missing B (GCMB) mutations (Arg39Stop and Arg110Trp) that result in loss of subcellular localization and DNA binding, respectively, are associated with autosomal recessive hypoparathyroidism

Bowl MR , Mirczuk S , Cranston T , Bahl S , Allgrove J , Nesbit MA , Thakker RV

GCMB, which is the mammalian homologue of the Drosophila gene Glial cells missing, encodes a 506 amino acid parathyroid-specific transcription factor that contains: a GCM DNA-binding domain at residues 19–176; a predicted nuclear localization signal (NLS) at residues 176–193; an inhibitory domain at residues 258–347; and two transactivation domains at residues 174–263, and residues 428–506. To date only six different GCMB mu...

ea0019p5 | Bone | SFEBES2009

Identification of a kindred from Northern Ireland with familial hypocalciuric hypercalcaemia type 3, which maps to chromosome 19q13.3

Nesbit MA , Hannan FH , Graham U , Hunter S , Morrison PJ , Thakker RV

Familial hypocalciuric hypercalcaemia (FHH) is an autosomal dominant disorder of mineral metabolism that is characterized by lifelong elevation of serum calcium concentrations associated with inappropriately low urinary calcium excretion (calcium clearance:creatinine clearance <0.01). Three separate FHH loci have been identified (FHH1-3). Loss-of-function mutations of the calcium-sensing receptor (CaSR) gene located on 3q21.1, which account for the majority of FHH c...

ea0019p387 | Thyroid | SFEBES2009

PTPN22 genotype is a determinant of age of onset of Graves’ disease

Karamat MA , Simmonds MJ , Newby PR , Heward JM , Franklyn JA , Gough SC , Brand OJ

PTPN22, encodes lymphoid tyrosine phosphatise (LYP), an important inhibitor of T lymphocyte activation and has been associated with numerous autoimmune diseases including type 1 diabetes, rheumatoid arthritis, and Graves’ disease (GD). Consistent association has been reported between disease and a non-synonymous SNP +1858 C>T (rs2476601) encoding an Arginine to Tryptophan substitution at amino acid 620 of LYP. Our group was the first to show strong evidence of ...

ea0016p385 | Neuroendocrinology | ECE2008

The choice of therapy in acromegaly: results of treatment at a tertiary care hospital

Isidro Ma Luisa , Castro Jose Antonio , Penin Manuel , Armenta Jacinto , Cordido Fernando

Objective: The aim of our study was to investigate the characteristics of the acromegalic patients followed at a tertiary Universitary Hospital and to evaluate the results of the recommended treatment protocols.Patients and methods: All our acromegalic patients were included (n=48; 27 women). Demographic, hormonal, visual and imaging data at diagnosis and during follow-up, as well as treatments applied, were recorded.Results...

ea0012oc3 | Young Endocrinologist prize session | SFE2006

Co-administration of SR141716 with peptide YY or oxyntomodulin has additive effects on food intake in mice

White NE , Dhillo WS , Small CJ , Lui YL , Gardiner JV , Ghatei MA , Bloom SR

BackgroundSR141716 (Rimonabant) has been shown to significantly inhibit food intake and reduce body weight in rodents and humans by antagonising CB1 receptors. The gut hormones peptide YY3–36 (PYY3–36) and oxyntomodulin (OXM), released from L-cells in the small intestine inhibit food intake in both rodents and humans and this effect is thought to be mediated via the hypothalamus.Objective<...

ea0012p56 | Endocrine tumours and neoplasia | SFE2006

Dopamine-secreting paraganglioneuroma – maintain high index of suspicion

Mallina Ravi K , Simon Godwin , Close Peter J , Ma’en Al-Mrayat

Paraganglioneuromas producing predominantly dopamine are very rare. Such tumours are potentially malignant and often tend to have atypical clinical presentation. Majority of the patients are normotensive and tumours are detected incidentally on imaging studies. We report a case of dopamine secreting – malignant paraganglioneuroma with spinal metastasis. A 65-year-old man was referred to the endocrinology clinic after an incidental finding of large right para-adrenal mass ...