Searchable abstracts of presentations at key conferences in endocrinology

ea0012p75 | Pituitary | SFE2006

Suprasellar arachnoid cyst: a surgically reversible cause of hypothalamo-pituitary dysfunction

Mallina Ravi K , Simon Godwin , Close Peter J , Al-Mrayat Ma’en

Endocrine manifestations of arachnoid cysts, including suprasellar arachnoid cysts(SAC) are not well recognized. The effect of neurosurgical interventions on such manifestations is also not well reported. Here in we report a case of a young man with hypothalamic dysfunction secondary to SAC who made a good recovery after surgical treatment of the cyst.A 22-yr-old man was referred to our endocrine clinic for evaluation of progressive weight loss and malai...

ea0011oc26 | Diabetes and metabolism | ECE2006

Neuropeptide S is a novel peptide which potently stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake

Smith KL , Patterson M , Dhillo WS , Patel SR , Semjonous NM , Gardiner JV , Ghatei MA , Bloom SR

Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in the modulation of arousal and fear responses. It has also been shown that lateral ventricle administration of NPS causes a significant decrease in food intake. Neuropeptides involved in the modulation of arousal have been shown to be involved in the regulation of the hypothalamo-pituitary adrenal (HPA) axis and food intake.Objective: To examine the effect of NPS on the regulati...

ea0011p416 | Diabetes, metabolism and cardiovascular | ECE2006

Severity of depression in patients with type 1 and type 2 diabetes and its relation to the level of glycemia control and anti-depressive therapy

Tsutskiridze LR , Kurashvili RB , Kurashvili GR , Khelashvili MG , Nishnianidze MA , Shelestova EL , Dundua MG

Background and Aims: There are consistent findings about increased prevalence of depressive disorders in diabetes. The aim of the study was to reveal prevalence of depression in patients (pts) with type 1 (DM1) and type 2 (DM2) diabetes.Materials and Methods: Totally, 157 pts with DM were questioned. To assess depression degree Beck’s scale was used, and 83 depressive pts (scores >10), were allocated into 2 groups (Gr.): Gr.1 (n=44)–...

ea0011p487 | Endocrine tumours and neoplasia | ECE2006

PTTG promotes a novel VEGF-KDR-ID3 autocrine mitogenic pathway in thyroid cancer

Kim DS , Buchanan MA , Stratford AL , Susarla R , Watkinson JC , Eggo MC , Franklyn JA , McCabe CJ

VEGF exerts its effects by binding to two tyrosine kinase receptors, KDR and VEGFR1. KDR is critical for transmitting signals for proliferation and migration of endothelial cells but is also expressed in several non-endothelial cells, and is elevated in some human tumour cells. We investigated KDR expression in human thyroid epithelial cells in vitro and thyroid cancers compared with normal thyroid samples examined ex vivo. Expression of KDR was demonstrated usin...

ea0011p592 | Neuroendocrinology and behaviour | ECE2006

Appetite regulating hormones in constitutionally lean and anorexia nervosa subjects

Galusca B , Germain N , le Roux CW , Frere D , Ghatei MA , Bloom SR , Estour B

Energy balance is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY) and glucagon like peptide 1 (GLP-1). The commonest reason for young women in the developed world to be underweight is restrictive anorexia nervosa (AN). Constitutionally thinness (CT) has been described in young women who satisfies the WHO definition for moderate to severe underweight (BMI 13–16.9 kg/m2). CT women have...

ea0008oc9 | Neuroendocrinology and Reproduction | SFE2004

Triiodothyronine Directly Regulates Feeding

Martin NM , Kong WM , Smith KL , Gardiner JV , Small CJ , Ghatei MA , Bloom SR

The increased appetite associated with hyperthyroidism is assumed to be secondary to an increased metabolic rate. However, the role of thyroid hormones in appetite regulation is poorly understood. We hypothesised that thyroid hormones directly regulate food intake and studied the effects of peripheral and CNS administration of tri-iodothyronine (T3) on food intake in male Wistar rats in vivo.A single subcutaneous (s.c.) injection of 4.5 nmol per ...

ea0008p39 | Diabetes, metabolism and cardiovascular | SFE2004

Comparing Daily Glycaemic Control with Insulin Glargine added to Oral Agents versus Twice-daily Premixed Insulin Alone in Type 2 Diabetes

Janka HU , Plewe G , Kliebe-Frisch C , Schweitzer MA , Yki-Jarvinen H

This 24-week, multicentre, open, parallel group study compared the efficacy and safety of two different regimens for initiating insulin therapy. Insulin-naive patients with fasting blood glucose (FBG) levels >=6.7 mmol/L (>=120 mg/dL) and HbA1c levels 7.5-10.5% on oral antidiabetic agents (OADs: glimepiride [Amaryl] or other sulfonylureas plus metformin) were randomized to insulin glargine (LANTUS) once daily in the morning with continued OADs (Glarg + OADs) o...

ea0008p43 | Diabetes, metabolism and cardiovascular | SFE2004

Effect of ghrelin on insulin-stimulated glucose uptake in adipocytes and role of the growth hormone secretagogue receptor type 1a

Patel A , Stanley SA , Gardiner JV , Ghatei MA , Frost G , Bloom SR

The endogenous growth hormone secretagogue (GHS), ghrelin, is an important regulator of energy homeostasis. Peripheral and central administration of ghrelin increase food intake, body weight and fat mass, effects which are mediated by the growth hormone secretagogue receptor type 1a (GHS-R 1a). Although the central actions of ghrelin on adiposity have been extensively studied, the direct peripheral effects of ghrelin on adipose tissue remain poorly understood. This study aimed...

ea0056p852 | Pituitary - Clinical | ECE2018

Psychopathology in Cushing’s disease and acromegaly

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Webb Susan M

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

ea0090p53 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in human serum and adipose tissues and In Vitro stimulatory effect of naphthalene in adipogenesis in 3T3-L1 cells

Mlyczyńska Ewa , Bongrani Alice , Rame Christelle , Węgiel Małgorzata , Maślanka Anna , Major Piotr , Zarzycki Piotr , Ducluzeau Pierre-Henri , De Luca Arnaud , Bourbao-Tournois Celine , Froment Pascal , Rak Agnieszka , Dupont Joelle

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...