Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1161 | Late Breaking | ECE2023

Are there any benefits of probiotic or prebiotic supplementation in hypothyroid patients? A systematic review with meta-analysis

Zawadzka Karolina , Kałuzińska Klaudia , Świerz Mateusz J. , Sawiec Zuzanna , Antonowicz Ewa , Leończyk-Sporna Monika , Kamal Abadi Ahmad , Trofimiuk-Muldner Małgorzata , Bała Małgorzata M.

Introduction: A number of studies indicate the presence of a thyroid-gut axis and the important influence of the gut microbiota on thyroid function. As prebiotics, probiotics and synbiotics show therapeutic potential in the treatment of intestinal dysbiosis, we aimed to evaluate the efficacy of their supplementation in patients with primary hypothyroidism.Material and methods: We searched electronic databases (Ovid MEDLINE, Embase, CENTRAL), registers of...

ea0044p157 | Neuroendocrinology and pituitary | SFEBES2016

Use of biguanides in the treatment of pituitary adenomas, an in vitro approach

Ibanez-Costa Alejandro , Carmen Vazquez-Borrego Ma , Fuentes-Fayos Antonio C. , Venegas-Moreno Eva , Galvez Ma Angeles , Soto-Moreno Alfonso , Kineman Rhonda D. , Castano Justo P. , Luque Raul M.

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbi-mortality. Although somatostatin analogs and dopamine antagonists constitute the main medical treatments for PAs, an appreciable subset of patients are resistant or poorly responsive to these drugs and hence is crucial the search for new therapies. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (PF) and buformin (BF) have been s...

ea0081p520 | Adrenal and Cardiovascular Endocrinology | ECE2022

Cortical-sparing adrenalectomy for bilateral pheochromocytoma - is it a game worth the candle? Systematic review with meta-analysis comparing total vs partial adrenalectomy in bilateral pheochromocytoma

Zawadzka Karolina , Tylec Piotr , Małłczak Piotr , Major Piotr , Pe¸dziwiatr Michał , Pisarska-Adamczyk Magdalena

Background: Bilateral total adrenalectomy (TA), despite causing persistent adrenal insufficiency with lifetime replacement of corticosteroids, is the method of choice in patients with bilateral pheochromocytoma. Partial adrenalectomy (PA) is an alternative approach that aims to balance tumor removal while maintaining adrenal function, although the oncological completeness of the procedure is questionable.Objective: The aim of this systematic review and m...

ea0081p447 | Reproductive and Developmental Endocrinology | ECE2022

Interplay between estrogen signaling and notch pathway in rodent Sertoli cells

Lustofin Sylwia , Kamińska Alicja , Brzoskwinia Małgorzata , Cyran Joanna , Bilińska Barbara , Hejmej Anna

Somatic cells of the seminiferous epithelium, called Sertoli cells, play a key role in germ cell development and maintenance of proper course of spermatogenesis. Although androgens are considered the main regulators of Sertoli cell activity, recent studies indicate that their metabolites, estrogens, also influence Sertoli cell function. Estrogens, act mainly through nuclear estrogen receptors α and β (ERα, ERβ), however non-classical signaling via ...

ea0081p710 | Reproductive and Developmental Endocrinology | ECE2022

Age- and body mass index-adjusted association between insulin sensitivity and risk factors for cardiovascular disease in polycystic ovary syndrome

Kałużna Małgorzata , Krauze Tomasz , Kompf Pola , Ziemnicka Katarzyna , Andrzej Wykretowicz , Ruchala Marek , Guzik Przemyslaw

Introduction: Impaired insulin sensitivity accompanies polycystic ovary syndrome (PCOS). Women with PCOS are usually at risk of premature cardiovascular disease, which increases with age and body weight. We studied the link between insulin sensitivity measured by the Matsuda Insulin Sensitivity Index (MISI) adjusted to body mass index (BMI) and age in otherwise healthy PCOS women.Methods: 250 adult women with PCOS of reproductive age (18-43 years old) un...

ea0081p231 | Thyroid | ECE2022

Congestive heart failure as a first-time presentation of thyrotoxicosis in COVID-19 positive patient

McKay Ellen , Elhilo Mousa Kalthoom , Abrar Ul Haq Muhammad , Kelly Karen , Shafi Rummun Mohamad , Fleming Sean , Pyeh Kyithar Ma

Background: The clinical manifestations of thyrotoxicosis do not always correlate with the extent of thyroid biochemical abnormalities. Here, we report the case of a COVID-19 positive patient who presented with congestive heart failure as a first-time presentation of thyrotoxicosis. Case report: A 40-year-old female presented to Emergency Department with two days history of lower limb oedema and abdominal distension. She denied dyspnoea, chest pain, palp...

ea0081ep113 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenal venous sampling in patients with hyperaldosteronism

Rebollo-Roman Angel , Serrano Laguna Ma del Carmen , Perez-Montilla Maria-Eugenia , Moreno-Moreno Paloma , Moreno Maria Angeles Galvez

Objective: Adrenal venous sampling (AVP) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide the treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVPs.Methods and patients: Observational longitudinal clinical study between July 2020 and September 2021 in patients who underwent AVP in our Hospital.<p c...

ea0081ep420 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Flash glucose monitoring in DM1: Our experience in a secondary referral hospital

Serrano Laguna Ma del Carmen , Barrera-Martin Ana , Rebollo-Roman Angel , Silva-Fernandez Julia , Galvez Moreno Maria Angeles

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of patients in a secondary referral hospital and their glycemic control expressed as FGM targets.Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 referred to a secondary care center in Montilla (Córdoba).Results: 101 patients included. Mean a...

ea0090p551 | Adrenal and Cardiovascular Endocrinology | ECE2023

Does this patient really have a pheochromocytoma? A retrospective analysis of patients undergoing adrenalectomy overdiagnosed with pheochromocytoma

Zawadzka Karolina , Małczak Piotr , Wysocki Michał , Major Piotr , Pędziwiatr Michał , Pisarska-Adamczyk Magdalena

Background: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumours that secrete catecholamines. Methoxycatecholamines in free plasma or fractionated methoxycatecholamines in 24-hour urine collections are the recommended tests for the diagnosis of pheochromocytoma, based on which patients are referred for surgical removal of the adrenal gland. However, false-positive results from these tests remain a problem and some patients are referred for adrenalectomy due to ...

ea0090ep57 | Adrenal and Cardiovascular Endocrinology | ECE2023

Adrenal venous sampling in patients with hyperaldosteronism

Moyano-Sanchez Ana Maria , Rebollo-Roman Angel , Serrano Laguna Ma del Carmen , Moreno-Moreno Paloma , Galvez Moreno Maria Angeles

Objective: Adrenal venous sampling (AVS) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVS.Methods and patients: Observational longitudinal clinical study between July 2020 and November 2022 in patients who underwent AVS in our Hospital.<p class="...