Searchable abstracts of presentations at key conferences in endocrinology

ea0032p758 | Obesity | ECE2013

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a meta-analytic study

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Saad Farid , Luconi Michaela , Lucchese Marcello , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Few randomised clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally showed an increase in testosterone levels. The aim of the present study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels.Methods: An extensive Medline searc...

ea0032p864 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Moderate hyponatremia is associated with an increased risk of overall mortality: a comprehensive meta-analysis

Corona Giovanni , Giuliani Corinna , Parenti Gabriele , Norello Dario , Verbalis Joseph G , Forti Gianni , Maggi Mario , Peri Alessandro

Introduction: Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a comprehensive meta-analysis that included all the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.Methods: An extensive Medline, Embase, and Cochrane search was perfo...

ea0026p315 | Obesity | ECE2011

Testosterone and metabolic syndrome: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Abersa Antonio , Tishova Yuliya , Saad Farid , Lenzi Andrea , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in MetS has not been completely clarified.To systematically analyse the relationship between androgen levels and MetS we performed a review and meta-analyses of available prospective and cross-sectional studies. A specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was als...

ea0022oc1.4 | Diabetes and obesity | ECE2010

The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction

Corona Giovanni , Boddi Valentina , Balercia Giancarlo , Giulia Rastrelli , de Vita Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Previous clinical studies on effect of statins treatment on testosterone levels have produced mixed results. The aim of the present study is to evaluate the association between statin therapy and hormonal parameters in a large series of subjects seeking medical care at our Unit for ED.Methods: A consecutive series of 3484 (mean age 51.6±13.1 years) patients with ED was studied.Several hormonal and biochemical par...

ea0022p487 | Female reproduction | ECE2010

Hormonal correlates of different ejaculatory latencies in subjects with sexual dysfunction

Corona Giovanni , Jannini Emmanuele , Lotti Francesco , Boddi Valentina , de Vita Giulia , Forti Gianni , Lenzi Andrea , Mannucci Edoardo , Maggi Mario

Introduction: Although it is well established that all the aspects of male reproduction are hormonally regulated, the endocrine control of the ejaculatory reflex is still not completely clarified. Sex steroids, thyroid and pituitary hormones (oxytocin and prolactin) have been proposed to control the ejaculatory process at various levels, however, only a few reports are currently available. The aim of the present study is to evaluate the contribution of testosterone, TSH and pr...

ea0022p535 | Male reproduction | ECE2010

Testosterone partially ameliorates metabolic profile and erectile responsiveness to PDE5 inhibitors in an animal model of male metabolic syndrome

Vignozzi Linda , Filippi Sandra , Morelli Annamaria , Chavalmane Aravinda K , Sarchielli Erica , Vannelli Gabriella B , Mannucci Edoardo , Maggi Mario

Metabolic syndrome (MetS) is a clustering of cardio-metabolic risk factors (hyperglycemia, hypertension, dyslipidemia, visceral fat accumulation) that is also associated with hypogonadism and erectile dysfunction (ED). The study was aimed at clarifying the relationships among MetS, hypogonadism, and ED, we developed an animal model of MetS.Methods: Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared wit...

ea0022p737 | Steroid metabolism &amp; action | ECE2010

Expression and biological function of sex steroid receptors in male human bladder

Vignozzi Linda , Chavalmane Aravinda K , Comeglio Paolo , Morelli Annamaria , Filippi Sandra , Fibbi Benedetta , Vannelli Gabriella B , Maggi Mario

In male, lower urinary tract symptoms (LUTS) have been associated, beside benign prostatic hyperplasia, to some unexpected co-morbidities, such as hypogonadism, obesity and metabolic syndrome, which are essentially characterized by an unbalance between circulating androgens and estrogens. Within the bladder, LUTS have been linked to overactivity of the RhoA/ROCK pathway. Here we investigate the effects of changing sex steroids on bladder smooth muscle. The effects of androgens...

ea0016p224 | Diabetes and cardiovascular diseases | ECE2008

Atorvastatin ameliorates penile erection and sildenafil responsiveness in two distinct animal models of chemical diabetes and inhibits high glucose-induced alterations in human penile smooth muscle cells

Morelli Annamaria , Filippi Sandra , Vignozzi Linda , Zhang Xin-Hua , Mancina Rosa , Fibbi Benedetta , Chavalmane Aravinda , Silvestrini Enrico , Maggi Mario

One of the proposed mechanisms responsible for Diabetes mellitus (DM)-associated erectile (ED) dysfunction is overactivity of RhoA/ROCK signalling. Because statins may decrease RhoA activation, we investigated whether atorvastatin ameliorated DM-induced ED in alloxan-treated (100 mg/kg) rabbits (in vitro studies) and streptozotocin-treated (STZ, 50 mg/kg) rats (in vivo studies). A subgroup of diabetic animals received atorvastatin 5 mg/kg per daily 2 weeks before...

ea0016p402 | Neuroendocrinology | ECE2008

Effect of hyperprolactinemia in male patients consulting for sexual dysfunction

Giovanni Corona , Mannuci Edoardo , Fisher Alessandra , Lotti Francesco , Ricca Valdo , Balercia Giancarlo , Petrone Luisa , Forti Gianni , Maggi Mario

Objectives: The physiological role of prolactin in male sexual function has not been completely clarified. Aim of this study is the assessment of clinical features and of conditions associated with hyperprolactinemia in male patients consulting for sexual dysfunction.Design and methods: A consecutive series of 2146 (mean age 52.2±12.8 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied a...

ea0016p508 | Obesity | ECE2008

NCEP-ATP-III defined metabolic syndrome, type 2 diabetes mellitus and prevalence of hypogonadism in male patients with sexual dysfunction

Corona Giovanni , Mannucci Edoardo , Petrone Luisa , Balercia Giancarlo , Paggi Federica , Fisher Alessandra , Lotti Francesco , Chiarini Valerio , Forti Gianni , Maggi Mario

Objectives: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are characterized by insulin resistance and often associated with male hypogonadism. To discriminate the specific contribution of T2DM and MetS to male hypogonadism.Design and methods: A consecutive series of 1134 (mean age 52.1±13 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied along with ANDROTEST, a 12-item ...