Searchable abstracts of presentations at key conferences in endocrinology

ea0022p106 | Bone/Calcium | ECE2010

Osteocalcin, OPG and RANKL circulating levels in adolescent idiopathic scoliosis

Popa Oana , Chiru Anton Mariana , Vladoiu Susana , Manda Dana , Ianas Olga

Background: Idiopathic scoliosis is a pathological entity of unknown etiology, characterized by a three-dimensional deformity of the spine and a low bone mass. The exact mechanism of bone loss in idiopathic scoliosis is unknown yet. However is well known that RANKL is a potent stimulator of bone resorption by binding receptor activator of nuclear factor-kB (RANK) in the osteoclasts cell membrane. OPG is a decoy receptor for RANKL, which interferes with RANKL/RANK binding and i...

ea0022p489 | Female reproduction | ECE2010

Polymorphisms in the estrogen receptor α gene and reproductive axis in women

Ianas Olga , Manda Dana , Savu Lorand , Vladoiu Suzana , Popa Oana , Rosca Roxana , Iordachescu Carmen

Background: ER-α gene (ESR1) polymorphisms have been associated with a variety of disorders including human infertility. In this study, we examined two polymorphisms of the estrogen receptor α (ESR1) gene, IVS-1 −397 T/C (dbSNP: rs2234693) and IVS-1 −351 A/G (dbSNP: rs9340799) in a sample of healthy women of reproductive age to determine whether are associated with hormonal levels for a better understanding of its biological actions in human development, ...

ea0022p623 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Circadian rhythmicity changes of gonadal and growth axis in adolescent idiopathic scoliosis

Manda Dana , Chiru Anton Mariana , Vladoiu Suzana , Popa Oana , Ianas Olga

Adolescent idiopathic scoliosis (IS) represents an evolutive disease that occurs in puberty and progresses till the skeletal maturation. The neuroendocrine hypothesis involving a melatonin deficiency as the source for IS is one of the proposed causes of this plurifactorial disease.Objective: To investigate the hormonal changes of both the gonadal and growth axis and circadian rhythmicity in subjects with adolescent idiopathic scoliosis compared to age ma...

ea0022p674 | Obesity | ECE2010

Osteocalcin and the metabolic syndrome

Oros Sabina , Ianas Olga , Rosca Roxana , Vladoiu Suzana , Manda Dana , Dumitrache Constantin

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

ea0022p741 | Steroid metabolism &amp; action | ECE2010

Sex specific association between estrogen receptor alpha PvuII and XbaI gene polymorphisms and hormones

Vladoiu Susana , Ianas Olga , Manda Dana , Savu Lorand , Popa Oana , Rosca Roxana

Objective: To explore if the polymorphisms of the estrogen receptor alpha gene, XbaI (IVS1-351 A/G) and PvuII (IVS1-397 T/C) are associated with age-dependent changes in hormone levels for a better understanding of the biological actions of estrogens.Subjects and methods: Subjects, both genders aged between 20 and 80 years were classified into two groups: reproductive age (1) and over 55 years (2). The study received the Ethical Committee approval. Morni...

ea0020p670 | Steroid Receptors | ECE2009

Association study of the estrogen receptor alfa gene polymorphism and age-dependent endocrine changes in a Romanian population

Ianas Olga , Manda Dana , Savu Lorand , Vladoiu Susana , Popa Oana , Rosca Roxana , Joja Oltea , Covic Marcela

Objective: The aim of this study is the characterizing of genetic variation in PvuII and XbaI polymorphisms of the ESR1 gene associated with age-dependent endocrine, metabolic and cognitive changes in a representative sample of Romanian population stratified by age and sex.Subjects and methods: Subjects, both genders aged between 20 and 80 yr were assigned to three lots 1) 177 subjects aged 55–80 years with moderately cognitive impairment (MCI) (MMS...

ea0016p426 | Neuroendocrinology | ECE2008

Enos, P22phox and apoE gene polymorphism associations with circulating hormone levels in the elderly

Ianas Olga , Manda Dana , Heltianu Constantina , Sima Anca , Raicu Monica , Covic Marcela , Dumitrache Constantin

Objective: The aim of this study was the identification of eNOS (G894T), p22phox (−930 A/G) and apoE gene polymorphisms associated with the impact of age-dependent endocrine changes.Subjects and methods: Subjects, both genders, were recruited and classified into the three groups: (1) 100 subjects aged 55–80+ years with mild cognitive impairment (MCI) (MMSE<28); (2) 165 age-matched subjects without cognitive impairment (MMSE>...

ea0016p536 | Obesity | ECE2008

The effect of polyunsaturated fatty acids enriched eggs on lipid profile and inflammatory markers

Manda Dana , Giurcaneanu Mihaela , Ionescu Liliana , Criste Rodica , Panaite Tatiana , Vladoiu Suzana , Busu Carmina , Ianas Olga

The correction of a subtle nutritional deficiency that may reduce the risk of a future chronic disease is indeed a challenge. One of the most intriguing current and future impacts on public health may come from a greater intake of omega-3 fatty acids such as α-linolenic acid (ALA).Objective: We investigated the effect of an increased amount of dietary α-linolenic acid (ALA) from enriched eggs on the lipid profile and inflammatory markers in hea...

ea0016p632 | Reproduction | ECE2008

Dynamic changes in the serum inhibin A and B levels correlated to reproductive hormones in women

Ianas Olga , Rosca Roxana , Vladoiu Suzana , Oros Sabina , Busu Carmina , Manda Dana , Dinu Dana , Jalba Pavel

To examine the hormonal characteristics related to age of reproductive axis, serum hormone profiles and inhibins A and B were investigated in fertile and menopausal women.Subjects: Forty-three cycling women (23–40-year-old) and 75 menopausal women (55–70-year-old) were studied. Serum 17-OHP, DHEA, DHEAS, androstendion, estradiol, estrone, progesterone, testosterone, free testosterone, DHT, SHBG, inhibin A and inhibin B, LH, FSH, Prl, TSH, GH, I...

ea0014p534 | (1) | ECE2007

Factors influencing the rhythmic secretion of melatonin in human

Rosca Roxana , Ianas Olga , Manda Dana , Vladoiu Suzana , Busu Carmina , Dinu Dana , Chioasca Carmen , Procopiuc Camelia

Objective: The present study examined the influence of light and dark, seasonal differences, electromagnetic fields, adrenergic and GABA-ergic control, age on melatonin secretion and also which factors affect rhythmicity of melatonin secretion, both in health and disease.Data were combined from a series of studies conducted between 1997 and 2006. Hormones were temporally assayed by immunometric assays.The results showed that melato...