Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep382 | Endocrine-Related Cancer | ECE2021

Nutritional assessment and Ghrelin system as predictors of clinical evolution in gastro-enteropancreatic neuroendocrine neoplasms

Carlos Manuel Alzás Teomiro , Soraya León-Idougourram , María Dolores Alcántara-Laguna , Gahete Manuel D. , María José Molina-Puertas , Justo P. Castaño , Raúl M. Luque , María Ángeles Gálvez Moreno , Aura D. Herrera-Martínez

BackgroundPatients with neuroendocrine neoplasms (NENs) might present with malnutrition due to the tumor itself and/or its treatment. Poor nutritional status and weight loss can lead to poor outcomes, including decreased quality of life, increased complication rates and mortality. Ghrelin is an orexigenic hormone, which is implicated in appetite regulation, body weight, inflammation and immune cell activation. Its gastric secretion mainly depends on the ...

ea0070aep654 | Pituitary and Neuroendocrinology | ECE2020

Our experience with lu-dotatate in patients with neuroendocrine tumors in a tertiary hospital

Munoz Diego , Carlos Percovich Hualpa Juan , Weber Bettina , Atencia Goñi José , González Fernández Laura , Miguélez González María , Brox Torrecilla Noemí , José Añez Ramos Roberto , Maricel Rivas Montenegro Alejandra , López Guerra Aurelio , Lucía Olmedilla Isishi Yoko , Ángeles Vélez Romero María , Ágreda García Javier , Picallo Pérez María , Monereo Megías Susana , García Centeno Rogelio

Introduction: Lutetium-177-DOTATATE (Lu177) is approved in patients with well-differentiated (G1 and G2) neuroendocrine tumors (NETs) positive to somatostatin receptors, progressive and unresectable or metastatic. Lu177 has been shown to increase progression-free survival and the quality of life of these patients.Material and Methods: Retrospective descriptive study of a series of 15 cases with NETs treated with Lu177. Demographic data, tumor characteris...

ea0073aep809 | Late Breaking | ECE2021

Comparison of the clinical efficacy of Semaglutide between DPP4-inhibitor-naive and DPP4-inhibitor-experienced patients in a real world setting in Spain

Roberto Miguel Sierra Poyatos , Jersy Jair Cardenas Salas , Luiza Luca Bogdana , Nancy María Sanchez Gomez , Naiara Modroño Mostoles , Begoña Sánchez Lechuga , Cruces Vega Eva , Maria Jesus Silva Rodriguez , María De La Paz Gómez Montes , Diego Meneses González , Montoya Alvarez Teresa , María de los Angeles Velez Romero , Estrella Santos Alicia , Ortega Juaristi Maite , Maria De Los Angeles Gonzalo Redondo , Vazquez Martinez Clotilde

IntroductionGlucose and weight control effectiveness in patients with Type 2 diabetes (T2D) in treatment with DPP4 inhibitors (DPP4i) that switch to semaglutide is scarce. We aim to assess it in a real-world setting of DPP4i-experienced patients and compare it to DPP4i-naive patients.MethodsPatients with T2D that were prescribed Once-Weekly semaglutide in 4 hospitals in Madrid-Spain were identified. Patients ...

ea0081ep318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Role of incretins, gut microbiota and permeability in the remission of type 2 diabetes mellitus after bariatric surgery

Hernandez-Montoliu Laura , Puig Rocio , Pellitero Silvia , Vendrell Joan , Fernandez-Veledo Sonia , Guerrero Fernando , Vidal Anna , Rodriguez M. Mar , Montseny Rosa , Vilarrasa Nuria

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

ea0063gp106 | Adrenal and Neuroendocrine - Basic | ECE2019

Gene expression changes in visceral adipose tissue of Cushing syndrome.

Garcia-Eguren Guillermo , Gonzalez Mar , Blanco Enrique , Giro Oriol , Vidal Oscar , Carmona Francesc , Casals Gregori , Mora Mireia , Halperin Irene , diCroce Luciano , Hanzu Felicia A

Introduction: Visceral adipose tissue (VAT) is the key target tissue of glucocorticoids (GC) during active Cushing Syndrome (CS) and a metabolic tissue associated to insulin-resistance and an increased cardiometabolic risk. Till date there are no data regarding gene expression in VAT in CS and only few data about the mRNA in subcutaneous one. The aim of this study was to study the visceral VAT tissue transcriptional changes in ACTH-independent CS.Methods...

ea0041ep550 | Diabetes therapy | ECE2016

Effects in weight loss and HbA1c after one year of use of dapaglifozina

de Linares Lidia Urbon Lopez , Soto Maria Cristina Crespo , Terroba Concepcion , Ventosa Marta , Martin Tomas , Calleja Maria del Mar , Cuellar Luis Angel

Changes in HbA1c and weight after 1 year on dapaglifozina added to the previous treatment.SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes.The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine.Therefore hyperglycemia decreases and so does weight as happens with t...

ea0035p137 | Calcium and Vitamin D metabolism | ECE2014

Effects of nutritional intervention program on vitamin D serum levels in adolecents

Pastor M Mar Campos , Pardo Ma Dolores Serrano , Soto Ma Luisa Fernandez , de Dios Luna del Castillo Juan , Gomez-Villalba Fernando Escobar , Escobar-Jimenez Fernando

Introduction: Vitamin D deficiency and insufficiency is highly prevalent even in young people. Vitamin D status has been linked to the BMI and insulin resistance.Aim: Determine 25(OH)D concentrations in adolescents before and after nutritional intervention program (NIP) and its relationship to BMI and metabolic syndrome (MS).Methods: We selected 256 secondary school students (127 males) aged between 12 and 16 years from Granada (Sp...

ea0035p500 | Diabetes therapy | ECE2014

Liraglutide effects on glycaemic control, body weight, blood pressure and lipid profile in obese patients with type 2 diabetes: real-life clinical practice

Fernandez-Garcia Jose Carlos , Mancha-Doblas Isabel , Cortes-Salazar Carmen Maria , Picon-Cesar Maria Jose , Gomez-Perez Ana Maria , Roca Mar , Tinahones Francisco

Objective: To evaluate the efficacy of liraglutide, a new glucagon-like peptide 1 analogue, on glycaemic control, body weight, blood pressure and lipid profile in obese patients with type 2 diabetes mellitus (T2DM).Material and methods: Patients attending a tertiary Endocrinology Unit who were prescribed liraglutide (January 2013–December 2013) and assessed both at baseline and first post-initiation visit were included in the analysis. The primary e...

ea0070aep9 | Adrenal and Cardiovascular Endocrinology | ECE2020

Persistent transcriptional disruption and histone mark modifications on visceral adipose tissue after remission of hypercortisolism

García-Eguren Guillermo , Gonzalez Mar , Vizan Pedro , Giro Oriol , Beyhart Arturo , Mora Mireia , Halperin Irene , Enseñat Joaquim , Vidal Oscar , Carmona Francisco , DiCroce Luciano , Hanzu Felicia

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...

ea0070aep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Relationship between blastocystis sp. parasitization and metabolic syndrome in an obese spanish population

Caudet-Esteban. Jana , Cifre Martinez Susana , Trelis Villanueva María , Camara-Gómez Rosa , Palasí Rosana , Merino Torres Juan Francisco

Introduction: Blastocystissp. (BS) is the most common intestinal parasite that is isolated in human fecal samples. Its pathogenic role is still questioned. While some consider it a beneficial component of the human intestinal microbiota, some evidence relates it with dysbiosis and development of metabolic syndrome (MS). Its presence has been inversely correlated with BMI.Objective: The objective of this study is two-fold: determining the prevale...