Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep372 | Pituitary and Neuroendocrinology | ECE2020

Pasireotide therapy in a patient with pituitary macroadenoma and asymptomatic acromegaly resistant to first generation somatostatin analogues

Concepción Terroba-Larumbe María , Palacio-Mures Jose Maria , Crespo-Soto Cristina , Ventosa-Viña Marta , Cuellar-Olmedo Luis , Acuña-Garcia Manuel , Anacabe-Goyogana Itziar , Areli Ticona-Spinoza Danay , Maria Delgado-Sanz Jose , Angel Rodriguez Garcia Javier

Introduction: Acromegaly increases morbidity and mortality and should be treated even in the asymptomatic phase. It is almost always caused by a GH-producing pituitary adenoma and although transsphenoidal surgery is the treatment of choice in most cases, in others, primary medical therapy is indicated.Clinical case: A 36-year-old female with a family history of thyroid functional pathology and diagnosed with micronodular goiter was evaluated in February ...

ea0070ep432 | Thyroid | ECE2020

Clinical approach after a Bethesda 4 result in a thyroid cytology

Alhambra Expósito Mª Rosa , Barrera-Martín Ana , Rebollo-Román Ángel , Segui-Azpilcueta Pedro , Ángeles Gálvez-Moreno María

Introduction: Thyroid nodules are a very common finding in sonographies (20–75% people). Criteria for clinical management and for cytological diagnosis (-Bethesda system) are well standardized. In spite of this, a gap of knowledge exists as far as management of Bethesda 4 is concerned.Aim: Evaluate the clinical approach of Bethesda 4 (B4) result in a thyroid cytology.Material and Methods: Retrospective study of thyroid nodule...

ea0014p314 | (1) | ECE2007

A novel pro-migratory action of TGFb in papillary carcinoma

Rodríguez García-Renueles María Elena , Bravo López Susan Belen , Seoane Rafael , Puig Carmen Gil , Teijeiro José Cameselle , Barreiro Francisco , Villamarín Clara Álvarez

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...

ea0073oc9.1 | Oral Communications 9: Endocrine-Related Cancer | ECE2021

Thymic neuroendocrine tumor and mortality in MEN 1 patients: the spanish registry

Casteras Anna , Valdés Nuria , Lamas Cristina , Gaztambide Sonia , Paja Fano Miguel , Navarro Elena , Álvarez Escol Cristina , Diego Estrella , Calatayud María , Segura Pedro , Oriola Josep , Spanish group for the study of MEN and PPGL

BackgroundThymic neuroendocrine tumor (THY-NET) accounts for almost 20% of multiple endocrine neoplasia type 1 (MEN1)-associated mortality. Diagnosis at early tumor stage is associated with improved survival.ObjectiveTo study the prevalence, clinical features and prognosis of THY-NET in MEN 1. To describe the overall causes of death among the registered MEN1 patients. To compare and discuss our results with t...

ea0073aep241 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

GLP-1 receptor agonists and bariatric surgery in nonalcoholic steatohepatitis

Soraya León , María Dolores Alcántara-Laguna , Maria José Molina , Alfonso Jesús Calañas Continente , Concepción Muñoz , Maria Angeles Galvez Moreno , Aura D. Herrera-Martínez

RationaleObesity is associated with multiple comorbidities including nonalcoholic steatohepatitis (NASH). Despite its association with increased morbidity and mortality, treatment options are limited. Some studies have suggested that glucagon-like peptide-1 receptor agonists (aGLP-1) are associated with NASH resolution. Additionally, the effects of bariatric surgery on NASH-associated liver fibrosis are controversial.Methods<p ...

ea0073aep272 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Influence of nutritional status on clinical outcomes among hospitalized patients with covid-19

Keyla María Dotres Fallat , Nicolau Joana , Corao Luisa Ayala , Pilar Sanchís Cortés , Irene Rodríguez Rodríguez , Ana Gloria Soler Beunza , Romano Andrea Pompeo , Lluís Masmiquel Comas

Background and aimsSeveral factors that worsen the prognosis of the new coronavirus SARS-CoV-2 have been identified, such as obesity or diabetes. However, despite that nutrition may change in a lockdown situation, little is known about the influence of malnutrition among subjects hospitalized due to COVID-19. Our study aimed to assess whether the presence of malnutrition among patients admitted due to COVID-19 had any impact on clinical outcomes compared...

ea0073aep293 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effectiveness of semaglutide in obese patients with type 2 diabetes. a six-month clinical experience

Andrea Fernández Valero , José Ignacio Martínez Montoro , Ana María Gómez Pérez , Damas-Fuentes Miguel , Francisco José Tinahones Madueño

IntroductionSemaglutide is a glucagon-like peptide-1 receptor agonist which has shown important benefits in patients with type 2 diabetes mellitus (T2DM) in randomized clinical trials. Its commercialization in Spain began in May of 2019. The main purpose of this study was to analyze the effectiveness of this drug into routine clinical practice in patients with T2DM with a body-mass index above 30 kg/m2.Matherial and meth...

ea0073aep381 | Endocrine-Related Cancer | ECE2021

Case report: Secondary adrenal insufficiency and primary hypothyroidism following Nivolumab therapy in a patient with metastatic melanoma

Paloma González Lázaro , Tirado Antonio Moreno , Pascual Cristina Contreras , Mendez Cristina Montalban , María Zhao Montero Benítez , Inés Gómez García

IntroductionIn recent years, we have observed significant progress in cancer treatment associated with the development of immunotherapy. Nivolumab, an anti-PD-1 antibody, blocks the interaction between PD-1 and its ligands and inhibits the signaling pathway by preventing the tumor-derived PD-L1 from blocking T lymphocytes. In patients with metastatic melanoma, it is used either in monotherapy or in combination with other drugs. Immunotherapy is associate...

ea0073aep521 | Pituitary and Neuroendocrinology | ECE2021

Outcomes and complications of endoscopic pituitary surgery: A single-center study

Taibo Rocio Villar , Alicia Santamaría Nieto , Paula Andújar Plata , Antía Fernández Pombo , María Gemma Rodríguez Carnero , Ignacio Bernabeu Morón

ObjectivesTo present the results of our series of endoscopic surgery of PA, performed in a third level hospital by an experienced team.MethodsRetrospective review of PA undergoing endoscopic surgery between 2011 – 2018 in our institution. Clinical variables and radiological characteristics and outcomes were collected at diagnosis, before surgery and for an average of 4.8 years of postoperative follow-up....

ea0073aep800 | Late Breaking | ECE2021

Vitamin D deficit in type 2 diabetes patients during the winter in Northern Gran Canaria with and without supplementation

Alba Hernández Lázaro , Paula María Fernandez-Trujillo-Comenge , Ricardo de Leon-Durango , Kuzior Agnieszka , Manuel Esteban Nivelo Rivadeneira , Carmen Acosta-Calero , Claudia Arnas-Leon , Sara Quintana-Arroyo , Paula Gonzalez-Diaz , Francisco Javier Martinez-Martin

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...