Endocrine Abstracts

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

IntroductionThe pandemic has altered the day-to-day running of hospitals and most of the material and human resources have been made available for COVID-19 care. So have the residents in Endocrinology and Nutrition (MIR), who have been working on the front line, and this has led to alterations in their training programme. In addition, this unexpected and stressful work situation has had psychological consequences. The Spanish Society of Endocrinology and...

IntroductionThe SARS-Coronavirus-2 pandemic affects 248 469 people with 28 341 deaths in Spain as of June 28, 2020. Severe infection is more prevalent in patients with advanced ages, cardiovascular risk factors (CVRF) and chronic diseases (diabetes mellitus, cardiovascular disease and asthma). Having diabetes implies vulnerability to serious complications and death from coronavirus; although, not all diabetics have the same level of risk. The oldest is p...

Introduction: H. pylori infection has been related with extragastric diseases such as type 2 diabetes.Aim: to evaluate changes in carbohydrate metabolism induced by 75g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori compared to healthy controls.Materials and methods: A prospective case-control study. Biochemical parameters, carbohydrate profile, ghrelin and G...

Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and methods: A prospective study of 40 non-diabetics patients were perf...

Introduction: New diabetes treatments, such as lixisenatide, improve global metabolic status beyond glycemic control.Aim: To evaluate lixisenatide effects on liver function, lipids and blood pressure levels in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: This is a prospective study with a sample of 106 patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and ...

Introduction: Some treatments of diabetes, such as lixisenatide, improve global metabolic status beyond glycaemic control.Aim: To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type 2 diabetes and obese patients attended in Endocrinology Offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were...

Introduction: Gonadotroph tumours (GT) are the most common subtype of silent pituitary neuroendocrine tumours. The diagnosis of this subtype of tumours is established after surgery. There are no reliable markers of aggressiveness to predict their clinical course and, moreover, immunohistochemistry (IHC) usually classifies GT as null cell tumours. The aim of the present study was to correlate molecular, immunohistochemical and biochemical gonadotropin expression, to quantify th...

Background: NAFLD(non–alcoholic fatty liver disease) includes; non–alcoholic fatty liver(NAFL), non–alcoholic steatohepatitis (NASH) and its complications (fibrosis, cirrhosis and hepatocellular carcinoma). These diseases are currently the most common cause of liver disease in western countries, due to the obesity and DM2 epidemic. There are scores that determine the risk of liver fibrosis in a non–invasive way.Aims: To determine ...

Objectives: Semaglutide was approved for the treatment of T2DM patients with a body mass index (BMI) > 30kg/m2 by the Spanish National Health Service in May 2019. We evaluate clinical outcomes of patients on previous treatment with any another GLP1–RA that switch to Semaglutide.Material and Methods: Retrospective analysis. Sixty–five T2DM patients were included. Demographic data, anthropometric, systolic blood pressure (SBP), d...