Endocrine Abstracts

Background: Pancreatic Cancer (PC) is uncommon; however, it is one of the most deadly cancer types of all. New-onset diabetes (NOD) is associated with a higher risk of pancreatic cancer than general population, particularly if late-onset. An association between new-onset diabetes and increased mortality in patients with pancreatic cancer has been suggested but clinical relevant differences between those individuals with new-onset diabetes and those without are not well establi...

IntroductionIodine is an essential micronutrient used by the thyroid gland to produce thyroid hormones. Iodine deficiency during pregnancy is related to impaired neurocognitive development of fetus and neonate. The WHO recommends iodization of salt as main measure to prevent iodine deficiency disorders. In pregnant population other international organizations recommend the use of iodine supplements to guarantee adequate nutritional status of iodine (medi...

IntroductionThe main role of vitamin D is regulating bone metabolism, but over the past years, the importance of vitamin D in non-skeletal actions has been studied. Vitamin D deficiency is very common in our environment. This deficit has been associated with higher risk of many chronic diseases, such as osteoporosis, hypertension, diabetes and even obesity. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroi...

IntroductionToday, it is well recognized that disturbances in thyroid function may significantly affect mental status including emotion and cognition. Several studies have demonstrated the existence of a relationship between depression and hypothyroidism, although there is still no clear explanation of the pathophysiology that causes this association.ObjectivesTo assess whether there is a higher prevalence of...

Background: In bariatric surgery (BS) patients, nonalcoholic fatty liver disease and fibrosis are present in up to 90% and 24%, respectively. Several fibrosis risk scores have been developed and have been validated in cohorts different from morbid obesity (MO). We aimed to determine whether established liver fibrosis scores were accurate in predicting fibrosis in MO subjects.Material and Methods: Cross-sectional analysis in a cohort of MO patients underg...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an underdiagnosed complication in Type 2 Diabetes (T2D). This condition can evolve into steatohepatitis (NASH) and more severe entities such as liver cirrhosis and hepatic failure, being currently the first cause for liver transplantation in our environment. In Andalusian T2D patients, the exact prevalence is still unknown. Our aim is to assess the prevalence of NAFLD/NASH in a cohort of these patients.<p class="ab...

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

Introduction: Severe hypoglycemia and retinopathy are two of the main complications of diabetes mellitus (DM). Traditionally, glycosylated hemoglobin (or A1C) has been used as the gold standard measurement of glycemic control; however, there is a significant percentage of complications riskassociated with the evolution of diabetes that is not fully explained by this single marker. Short and long-term glycemic variability has been postulated as one of the main variables that co...

Introduction: Cyclic Cushing´s syndrome (CCS) is a rare disorder with a wide clinical variability, characterized by repeated episodes of cortisol excess and periods of normal or even low cortisol secretion. Different periodical diagnostic tests are required to confirm hypercortisolism and thereafter imaging techniques and laboratory studies can be performed to localize the cause.Case report: A 17-year-old female patient with a personal history of ad...

First generation somatostatin receptor ligands (SRL) are the first-line drugs in primary acromegaly treatment or after surgical failure in patients with active acromegaly. In previous studies we confirmed the association of the expression of SSTR2, Ki67 and E-cadherin (CDH1) in responsive GH-secreting adenomas response to SRL. Moreover, E-cadherin showed a greater predictive capacity than most of the markers described. Loss of E-cadherin is a typical mark of ...