Searchable abstracts of presentations at key conferences in endocrinology

ea0095p12 | Bone | BSPED2023

Impairment of muscle mass and muscle function in osteogenesis imperfecta: A systematic review

Hariri Caleb , McKechnie Jennifer , Mason Avril , Wong Sze Choong

Objective: This systematic review aimed to identify and analyze skeletal muscle outcomes in patients with osteogenesis imperfecta (OI), a condition characterized by structural and metabolic abnormalities in skeletal muscle. Specifically, the review focused on assessing muscle mass and function using various imaging modalities.Methods: A systematic search was conducted in MEDLINE and EMBASE databases. Inclusion criteria c...

ea0051p020 | Miscellaneous/other | BSPED2017

Blood pressure monitoring and management in young girls with turner syndrome

Murtaza Mohammed Ibrar , McVey Lindsey , Fletcher Alexander , Anderson Ellen , Leighton Emma , Wong Jarod , Mason Avril

Background: Hypertension (HT) is common in adults with Turner Syndrome (TS) but less is known about HT in children with TS.Aim: To determine the frequency of HT in girls with TS in West of Scotland and to assess its association with clinical characteristics. Patients and methods Retrospective cross-sectional analysis of 126 girls with TS in the West of Scotland, with at least 2 clinic blood pressure (BP) measurements in the preceding 12 months. HT was de...

ea0085p9 | Bone | BSPED2022

Bone biochemistry in children with fractures presenting with non-accidental injury

McDonald Heather , Forbes Owen , Lucas-Herald Angela , Houston James , McDevitt Helen , McNeilly Jane , Mason Avril

Background: Fractures are reported in 1/3 of children who have been abused. The Royal College of Paediatrics and Child Health (RCPCH) recommends that assessment of fractures where there is suspicion of physical abuse should include bone biochemistry: calcium (Ca), phosphate (Ph), alkaline phosphatase (ALP), parathyroid hormone (PTH) and Vitamin D (VitD).Objectives: To describe the pattern of bone biochemistry in children with fractures when non-accidenta...

ea0085p32 | Miscellaneous 1 | BSPED2022

Service evaluation of girls with complex disability presenting with concerns regarding puberty

McKinney Georgia , Groom Tamsin , Mackay Vanessa , Choong Wong Sze , Mason Avril

Introduction: There are currently no recommendations on the assessment, investigation and follow-up for girls presenting with concerns regarding puberty with background of complex disability who are non-weight bearing.Aim: Service evaluation (assessment, investigation and follow-up) of girls presenting with any of Central Precocious Puberty (CPP), Early Puberty (EP), Delayed Puberty (DP) or period management with background of immobility in context of co...

ea0039oc6.4 | Oral Communications 6 | BSPED2015

Associated renal anomalies in children with Turner syndrome: 43-year experience from a single-centre

Lucaccioni Laura , Wong S C , Strano Rosario , Donaldson Malcolm , Cascio Salvatore , Mason Avril

Objective: To assess prevalence, clinical features, and follow-up of renal/urological malformations in patients with Turner syndrome (TS).Methods: The medical records of 182 patients with TS born between 1970 and 2013 were retrospectively reviewed.Results: Twenty-one girls (11.5%) were identified with renal/urological anomalies: 15 (71%) horseshoe kidney (HSK), 1 (4.7%) malrotation, 2 (9.5%) single kidney, and 1 (4.7%) duplex colle...

ea0039ep114 | Pituitary and growth | BSPED2015

Growth monitoring in girls attending a tertiary paediatric ENT service with middle ear disease

Bremner Morven , Carbarns Amy , Essa Ismail , Bradley Rebecca , Choong Wong Sze , Mason Avril , Kubba Haytham

Background: Recurrent middle ear disease may lead to poor growth or may suggest an underlying diagnosis associated with short stature. The aim of the study was to describe stature in a cohort of girls attending a paediatric ENT service.Methods: Height and weight was measured in all girls attending ENT clinics over an 8 week period (n=83). A mid-parental height (MPH) was calculated from reported parental heights. Th...

ea0036oc3.2 | Oral Communications 3 | BSPED2014

Vertebral fracture assessment in a paediatric population using dual-energy X-ray absorptiometry

Kyriakou Andreas , Shepherd Sheila , Lucaccioni Laura , Shaikh M Guftar , Mason Avril , Ahmed S Faisal

Background: Vertebral Fractures (VF) are recognized as an important aspect of bone health in children and adolescents. The clinical utility of vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry (DXA) has not been evaluated in the paediatric population.Method: VFA was performed independently by two non-radiologist observers, in 165 patients (77M/88F) as part of their investigation for low bone mineral density. Lateral thoracolumbar...

ea0036P18 | (1) | BSPED2014

Suppression of bone turnover and its determinants in children receiving bisphosphonate therapy

Kyriakou Andreas , McNeilly Jane D , McMillan Martin , Guftar Shaikh M , Mason Avril , Faisal Ahmed S

Introduction: Bisphosphonate therapy (BPT) reduces osteoclast activity and may be associated with adynamic bone turnover. The extent of suppression of bone turnover and its determinants are unclear.Methods: Markers of bone metabolism were evaluated in 15 children (9M/6F) receiving cyclical BPT intravenously for osteoporosis. The median age at first biochemical assessment was 10.8 years (0.16, 16.3). Serum type I collagen cross-linked C-telopeptide (CTX),...

ea0030p61 | (1) | BSPED2012

A prospective study of pubertal growth in children with inflammatory bowel disease

Mason Avril , Malik Salma , McMillan Martin , McNeilly Jane , Bishop Jonathan , McGrogan Paraic , Russell Richard , Ahmed Faisal

Background: Puberty is understood to be commonly affected in adolescents with CrohnÂ’s disease (CD) and ulcerative colitis (UC).Objective: To determine the impact of IBD on pubertal status and pubertal growth.Methods: Single centre prospective study over 12 months of 45 adolescents (boys, 23) with CD and 18 (boys, 12) with UC with a median age of 13.4 years (10, 16.6). Assessment included details of disease, anthropometry and b...

ea0028p110 | Clinical practice/governance and case reports | SFEBES2012

Audit of the West of Scotland endocrine adolescent transition clinic model, RHSC Glasgow, 2008–2010

Mason Avril , Donaldson Malcolm , Ahmed S. , McNeil Ethel , Campbell Victoria , Perry Colin , Shaikh M.

Introduction: Various models of transition are used to help engage and improve the health of young adults. Our transition clinic model: a multi-disciplinary endocrine Adolescent Transition Clinic (ATC), was instituted at the Royal Hospital for Sick Children, Glasgow, in October 2008 serving young people in the West of Scotland. A good transition process should improve clinic attendance, health outcomes and quality of life into adulthood.Aim: To review th...