Searchable abstracts of presentations at key conferences in endocrinology

ea0032p993 | Thyroid (non-cancer) | ECE2013

Levothyroxine requirements in thyroidectomized diabetic patients receiving metformin

Zafon Carles , Casteras Anna , Obiols Gabriel , Mesa Jordi

Background: Recent studies suggest that metformin (MF) may reduce TSH concentration. This fact could imply a dosage reduction of levothyroxine among those hypothyroid patients taking metformin.Aim: To determine, in a retrospective analysis, the impact of metformin in thyroidectomized patients (a condition not influenced by endogenous thyroid hormone production) on levothyroxine replacement.Patients and methods: One hundred ninety t...

ea0022p798 | Thyroid | ECE2010

Usefulness of sorafenib in the management of advanced thyroid carcinoma

Obiols Gabriel , Capdevila Jaume , Zafon Carles , Mesa Jordi

One of the most important activating genetic aberrations in differentiated thyroid cancer (DTC) development pathways involves the RET/PTC–RAS–RAF–MAPK axis. Mutations in the RET gene are essential in medullary thyroid carcinoma (MTC). Sorafenib is the first compound to reach clinical practice that is capable of inhibiting all the RAF kinases. Moreover, it targets a panel of tyrosine kinase receptors, such as VEGF receptors which gives to sorafenib not only proap...

ea0063p226 | Pituitary and Neuroendocrinology 1 | ECE2019

Metabolic fingerprint of acromegaly and its potential usefulness in clinical practice

Biagetti Betina , Herance JR , Ferrer Roser , Aulinas Anna , Mesa Jordi , Simo Rafael

Background: Acromegaly is a rare chronic and debilitating disease. More than half of patients are not well controlled and most of them require chronic surveillance. Although IGF1 and GH circulating levels are the main targets, they are not in close relationship with the behaviour of the tumour, the clinical course of the disease, the therapy response and the associated comorbidities. Metabolomics is an emergent research tool that we have used to examine in a massive manner the...

ea0037ep872 | Thyroid cancer | ECE2015

Role of thyroglobulin as a predictor of the evolution of disease in differentiated thyroid cancer

Biagetti Betina , Zafon Carles , Garcia-Burillo Amparo , Velasco Monica , Obiols Gabriel , Castell Joan , Mesa Jordi

Aim: Investigate, in patients with differentiated thyroid cancer (DTC) if thyroglobulin (Tg) values, immediately before and six months post radioiodine ablation are good predictors of disease progression.Materials and methods: Basal Tg values (Tg-B) and rhTSH stimulated Tg (Tg-S) before ablation (0) and 6 months later (6) from 142 DTC patients, with post-surgical ablation therapy between 2003 and 2009 with a follow up of 5 years, were analysed.<p cla...

ea0037ep905 | Thyroid cancer | ECE2015

Efficacy and safety of an outpatient low radioide dose for remnant thyroid ablation in low risk papillary thyroid carcinoma (PTC)

Obiols Gabriel , Garcia-Burillo Amparo , Zafon Carles , Castell Joan , Mesa Jordi

In PTC, radioiodine required dose for thyroid remnant ablation is uncertain. Recent works show that low doses may be sufficient for low risk patients.Aim: To evaluate the efficacy and safety of thyroid remnant ablation in patients with low-risk PTC by using 1100 MBq (30 mCi) outpatient doses.Materials and methods: Twenty-five patients (24 women, 55 years-old mean age, range 34–77) referred for ablation of postsurgical thyroid ...

ea0035p1083 | Thyroid Cancer | ECE2014

Langerhans cell histiocytosis and papillary thyroid carcinoma

Biagetti Betina , Diego Estrella , Dalama Belen , Iglesias Carmela , Gonzalez Oscar , Mesa Jordi

Introduction: Thyroid gland involvement by Langerhans Cell Histiocytosis (LCH) is a very rare condition. It occurs by thyroid infiltration that may result in hypothyroidism. LCH may be also related to neoplastic processes such as leukemias or lymphomas. However, the association with papillary thyroid carcinoma (PTC) is exceptional. We introduce a case and review the reported cases of this association.Case report: We describe a 33 year old patient diagnos...

ea0032p937 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Carbohydrate metabolism in acromegaly and treatment impact

Biagetti Betina , Valladares Silvia , Arnez Lorena , Dalama Belen , Obiols Gabriel , Mesa Jordi

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...

ea0022p778 | Thyroid | ECE2010

Clinical and histological different features in the form of presentation between papillary microcarcinomas and papillary carcinomas of larger size

Zafon Carles , Fort Jose Manuel , Baena Juan Antonio , Castellvi Josep , Obiols Gabriel , Monroy Gabriela , Mesa Jordi

Background and aim: Papillary thyroid carcinomas (PTCs) with a diameter <1 cm are referred to as papillary microcarcinomas (PTMCs). They are being diagnosed with increasing frequency. Within this type of tumour some clinical and histological characteristics with prognostic and therapeutic impact have been proposed. In the present study we describe the clinical and pathological presentation of PTMCs and compare them with papillary thyroid carcinomas of larger size.<p cl...

ea0041gp223 | Thyroid Cancer | ECE2016

Macro, but not micrometastases, detected by OSNA technique are related with more aggressive papillary thyroid cancer features

Zafon Carles , Iglesias Carmela , Gonzalez Oscar , Temprana Jordi , Caubet Enric , Garcia-Burillo Amparo , Obiols Gabriel , Serres Xavier , Mesa Jordi

Introduction: Classically, risk stratification in papillary thyroid carcinoma (PTC) assigned the same magnitude of risk to all patients with regional lymph node involvement (N1 disease). However, specific lymph node characteristics (such as size, number, extension, etc.) will allow individualizing treatment and follow-up. One-Step Nucleic Acid Amplification (OSNA) measures the number of copies of mRNA of cytokeratin 19 (CK19) as a marker of lymph node metastasis. Thus, copy nu...

ea0070aep699 | Pituitary and Neuroendocrinology | ECE2020

Determinants of epicardial fat in patients with acromegaly

Biagetti Betina , Herance Raúl , Casteràs Anna , Ferrer Roser , Mesa Jordi , Simo Canonge Rafael

Background: Epicardial adipose tissue (EAT), the visceral fat of de myocardium, has been positively related to insulin resistance (IR), cardiovascular risk and the left ventricular myocardial mass. Whether EAT thickness in acromegaly is mediated by GH/IGF-1, IR or other factors remains to be elucidated.Objective: The aims of this study were: 1) To investigate whether EAT in patients with ACRO is linked to IR and pro-inflammatory and anti-inflammatory rel...