Searchable abstracts of presentations at key conferences in endocrinology

ea0016p53 | Adrenal | ECE2008

Subclinical autonomous cortisol hypersecretion by adrenal incidentalomas may be intermittent: results from a long term follow-up study

Vassilatou Evangeline , Michalopoulou Stamatia , Vryonidou Andromachi , Manolis John , Panayiotopoulos Constantine , Tzavara Ioanna

Background: Hormonal studies have detected subtle abnormalities of the hypothalamic–pituitary–adrenal (HPA) axis due to autonomous cortisol secretion, in a percentage of patients with adrenal incidentalomas, a condition termed as subclinical Cushing’s syndrome. The diagnostic criteria and the clinical significance of this condition are still controversial and consequently there is uncertainty for its management. Data defining the natural course of these tumors, ...

ea0022p42 | Adrenal | ECE2010

Increased prevalence of metabolic syndrome in patients with subclinical autonomous cortisol hypersecretion by adrenal incidentalomas

Vryonidou Andromachi , Ioannidis Dimitrios , Vassilatou Evangelina , Katsoulis Kostas , Panagou Maria , Panayiotopoulos Kostas , Michalopoulou Stamatina , Tzavara Ioanna

Background: Subclinical autonomous cortisol hypersecretion is the most common hormonal abnormality in patients with adrenal incidentalomas, which is characterized by subtle abnormalities of the hypothalamic–pituitary–adrenal axis (HPA) due to adrenal autonomy. Possible detrimental effects of subclinical hypercortisolism in these patients are still under investigation.Objective: To investigate the prevalence of the metabolic syndrome (MS) in pat...

ea0049ep76 | Adrenal cortex (to include Cushing's) | ECE2017

Clinical course of patients with adrenal incidentaloma: retrospective analysis of a single center

Serrano Ana Carolina Ruiz , Colet Ana Megia , Cortes Silvia Naf , Ortega Joan Vendrell , Muela Inmaculada Simon , Fraile Esther Solano , Alevras Theodora Michalopoulou

In the adrenal incidentaloma (AI) it is fundamental to determine functionality and benignity. The aim of this study was to evaluated the clinical, radiological and hormonal evolution of AI and compare the frequency of autonomous cortisol secretion (ACS) between American and European Guidelines.Methods: Retrospective evaluation of patients with AI referred to our service in the last 5 years.Results: 140 patients were included, 50.9%...

ea0063p483 | Calcium and Bone 2 | ECE2019

Parathyroid hormone excess due to denosumab application and concomitant parathyroid adenoma with an atypical scintigraphic pattern- a case report

Askitis Dimitrios , Karanikas Michail , Michalopoulos Nikolaos , Strataki Aphroditi , Zissimopoulos Athanasios

Introduction: Primary hyperparathyroidism comprises one of the major causes of hypercalcaemia and is mostly due to solitary parathyroid adenoma. Denosumab is a novel antiresorptive agent for osteoporosis treatment and has been associated with a compensatory increase in PTH levels during the first months after injection, a fact that may interfere in the diagnostic procedures when dealing with concomitant small parathyroid adenomas without standard scintigraphic pattern.<p c...

ea0056p108 | Clinical case reports - Thyroid/Others | ECE2018

Syndrome carney-stratakis, new mutation report: SDH B: D138Y (c.412>T)

Serrano Ana Ruiz , Ciccia Alessandra Gabillo , Maduena Francisca Martinez , Gonzalez Salome Martinez , Ambros Josep Oriola , Simon-Muela Inmaculada , Ortega Joan Vendrell , Cortes Silvia Naf , Alevras Theodora Michalopoulou , Colet Ana Megia

Introduction: The Carney-Stratakis syndrome (CSS) is an inherited condition caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C or D that predispose to gastric stromal tumors (GIST) and multicentric paragangliomas (PGL). SDH acts as a tumor suppressor gene, and enzyme activity reduction is known to be oncogenic. Since 2002 there has been some scarce reports. We present a new case of CSS associated with a germline unknown significance mutation in exon 4 ...

ea0081p308 | Calcium and Bone | ECE2022

The impact of age on quality of life and frailty outcomes after parathyroidectomy in patients with primary hyperparathyroidism

Papavramidis Theodosios S. , Anagnostis Panagiotis , Pliakos Ioannis , Tzikos Georgios , Chorti Angeliki , Kotsa Kalliopi , Michalopoulos Antonios

Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx. Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019...

ea0037ep922 | Thyroid cancer | ECE2015

Incidence of intrathyroid location of parathyroid glands and description of their characteristics compared to extrathyroid ones

Michalopoulos Nick , Margaritidou Efterpi , Kotidis Efstathios , Sapalidis Konstantinos , Kanellos Ioannis , Panayiotou Kalliopi Pazaitou

Introduction: Total thyroidectomy (TT) is a safe and effective operation. The most frequent complication after TT is hypoparathyroidism. Surgical trauma, devasculisation of parathyroid glands and inadvertent parathyroidectomy have been identified as the main causes resulting in postoperative hypocalcaemia. The objectives of this study are to investigate the incidence of intrathyroid parathyroid glands (ITPGs) in a large cohort and to clarify their histological characteristics....

ea0070aep155 | Bone and Calcium | ECE2020

Do near-infrared intra-operative findings by the use of indocyanine green correlate with post-thyroidectomy parathyroid function? - the ICGPREDICT study

Papavramidis Thedosios , Anagnostis Panagiotis , Chorti Angeliki , Pliakos Ioannis , Panidis Stavros , Koutsoumparis Dimitris , Michalopoulos Antonios

Background/Aims: Post-operative hypoparathyroidism still remains a significant complication after thyroidectomy. Intraoperative imaging modalities, such as near infrared fluorescence by the use of indocyanine green (ICG), may assist to identify and preserve the parathyroid glands (PGs). The purpose of this study was to test the association between intra-operative ICG staining scoring system and 24-h post-operative parathyroid hormone (PTH) levels, as well as its capability of ...

ea0070aep649 | Pituitary and Neuroendocrinology | ECE2020

Multi-hormonal secretion in a young male with a large cystic pancreatic neuroendocrine neoplasm

Boutzios Georgios , Koukoulioti Eleni , Garmpis Nikolaos , Giovannopoulos Ilias , Bourgalis-Michalopoulos Konstantinos , Mantas Dimitrios

Introduction: The molecular pathogenesis of pancreatic neuroendocrineneoplasms (PNEN) is increasingly yet incompletely understood. PNEN typically occur sporadically or may occur within the context of hereditary tumor predisposition syndromes. PNEN can also be associated with endocrinopathy of hormonal hypersecretion. We present a young male with a multi-hormonal neuroendocrine neoplasm of pancreas.Case presentation: A 24-year-old male, non-smok...

ea0070aep711 | Pituitary and Neuroendocrinology | ECE2020

Isolated adrenocorticotropic hormone deficiency in a female with ectopic posterior hypophysis

Boutzios Georgios , Koukoulioti Eleni , Bourgalis-Michalopoulos Konstantinos , Giovannopoulos Ilias , Miliou Myrto , Papaoiconomou Eleni , Tsourouflis Gerasimos

Introduction: Some endocrine disorders, including hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency, are caused by an autoimmune response to endocrine organs. Previous data have also shown that isolated ACTH deficiency may be associated at least in part with a paraneoplastic syndrome. We present a rare case with isolated ACTH deficiency along with ectopic posterior hypophysis.Case presentation: A 53-yea...