Searchable abstracts of presentations at key conferences in endocrinology

ea0016p235 | Diabetes and cardiovascular diseases | ECE2008

Cumulative incidence, timing and risk factors for thyroid dysfunction in 144 Romanian patients treated with amiodarone

Trifanescu Raluca-Alexandra , Fica Simona , Ion Oana-Gabriela , Coculescu Mihail

Aim: To assess cumulative incidence and risk factors for amiodarone-induced thyroid dysfunction (AITD) in a large cohort of Romanian subjects.Subjects and methods: One hundred and forty-four patients (59 M/85 F), mean age 61.4±0.9 years, treated 2.4±0.2 years with amiodarone were assessed for TSH, TT3, TT4 (immunoradiometric assays) and FT4, TPO Ab (microenzymatic immunoassays). Thirty-three patients were reside...

ea0014oc6.3 | Cardiovascular endocrinology | ECE2007

Plasma brain natriuretic peptide (BNP) levels predict acute right ventricular dysfunction in pulmonary embolism – prospective study on 70 patients

Pascu Alina Mihaela , Rădoi Mariana , Coculescu Mihail

Background: Acute right ventricular dysfunction (RVD) on echocardiography (ECHO) is critical for risk stratification in pulmonary embolism (PE). Plasma BNP, a consecrated marker of left ventricular dysfunction, could represent a valuable biomarker of RVD in PE.Aim and objective: Assessment of plasma BNP levels in patients with PE in relationship with right ventricular (RV) function evaluated by ECHO.Methods: Prospective study of 70...

ea0014p83 | (1) | ECE2007

Insulin resistance and insulin secretion in non-diabetic acromegalic patients

Niculescu Dan , Purice Mariana , Lichiardopol Radu , Coculescu Mihail

Aim: To set up, in acromegaly without diabetes mellitus, a correlation between the disease activity in GH-secreting adenoma (AA) - assessed by minimum GH serum level during an oral glucose tolerance test (OGTT) - and severity of insulin resistance (IR), assessed by HOMA-IR index.Methods: 75 out of 88 consecutive patients with acromegaly hospitalized in our department were included in this study. 13 patients proved to have diabetes mellitus and were exclu...

ea0056p746 | Neuroendocrinology | ECE2018

Sox 2 expression in human pituitary adenomas-correlations with pituitary function

Capatina Cristina , Cimpeanu Anca , Raica Marius , Coculescu Mihail , Poiana Catalina

Introduction: Sox2 is a widely expressed marker of progenitor and stem cells in various organs, strongly expressed within Rathke’s pouch and the neural ectoderm. It exerts a critical role in the early stages of pituitary development but it is still expressed in the adult gland. Sox2 expression in pituitary adenomas and its possible correlation with clinicopathologic characteristics have not been investigated so far.Aim: To evaluate the immunohistoch...

ea0037ep757 | Pituitary: clinical | ECE2015

Cure rates and survival in patients with acromegaly

Galoiu Simona , Suvoiala Andreea , Purice Mariana , Caragheorgheopol Andra , Trifanescu Raluca , Coculescu Mihail , Poiana Catalina

Introduction: An improvement of survival in patients with acromegaly was claimed in the last years, with multimodal new therapies.Aims: To assess cure rates of different therapeutic protocols and the impact of these therapies on survival.Methods: 334 patients (224 F/110 M, mean age 48.1±0.7 years) with acromegaly admitted in a single Neuroendocrinology Department between Jan 2001 and Dec 2013 were retrospectively studied by GH...

ea0035p734 | Neuroendocrinology | ECE2014

Efficacy of early postoperative radiotherapy for nonfunctioning null cell or silent pituitary macroadenomas

Stancu Cristina , Gheorghiu Monica Livia , Galoiu Simona , Anghel Rodica , Badiu Corin , Coculescu Mihail

Background: Suitable postoperative radiotherapy (RT) of nonfunctioning pituitary macroadenomas (NFMAs) is still controversial, subjected to rapid technical and medical progress.Patients and methods.: We studied 87 patients with NFMA to identify factors affecting tumor control such as the time of RT and tumor pathology. Partial pituitary surgery was performed either by transfrontal (30 patients) or transsphenoidal (57 patients) approach. An immunoperoxida...

ea0032p98 | Bone and Osteoporosis | ECE2013

The follow-up in patients evaluated based on quantitative ultrasound: a prospective study

Carsote Mara , Radoi Valentin , Popescu Mihaela , Dusceac Roxana , Ene Cristina , Voicu Gabriela , Coculescu Mihail , Poiana Catalina

Introduction: The heel quantitative ultrasound (QUS) is useful tool in the assessment of fracture risk especially if cost issues are involved. It might be helpful in follow-up the patients who will not be treated with anti-osteoporotic drugs.Aim: To present the bone evaluation (DXA) after a period of time in patients who are initially assesed by both DXA and QUS.Material and patients: This is a prospective pilot study in a group of...

ea0032p594 | Female reproduction | ECE2013

PCOS subphenotypes stratification reveals an apparent increase of metabolic syndrome frequency in patients with concomitant hyperandrogenism and menstrual irregularities

Baculescu Nicoleta , Radian Serban , Gussi Ilinca , Gheorghiu Monica , Poiana Catalina , Grigorescu Florin , Coculescu Mihail

Background: PCOS-associated increased metabolic risk may be selective, owing to its heterogeneous nature. Identification of high-risk individuals could enable better studies and prevention of complications.Aim: To characterize the metabolic risk, as metabolic syndrome (MetS), of specific PCOS subphenotypes.Subjects and methods: Romanian PCOS (Rotterdam criteria) and 64 controls, 18–35 years. PCOS subphenotypes were defined: i)...

ea0032p860 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Doubled mortality ratio in female patients with non-functioning pituitary adenomas

Galoiu Simona , Baciu Ionela , Ioacara Sorin , Gheorghiu Monica , Badiu Corin , Poiana Catalina , Coculescu Mihail

Introduction: Patients with non-functioning pituitary adenomas (NFPA) and hipopituitarism had a reduced life expectancy.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in patients with NFPA in the last decade.Methods: A 196 patients (83 F/113 M, mean age 52.7±0.9 years) with NFPA admitted in a single Neuroendocrinology Department between January 2001 and December 2010 were retrospec...

ea0032p911 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The p.R16H AIP sequence variant is relatively frequent in Romanian sporadic pituitary adenoma patients

Radian Serban , Baciu Ionela , Capatina Cristina , Botusan Ileana , Ciubotaru Vasilie , Dumitrascu Anda , Coculescu Mihail , Poiana Catalina

Background: A large spectrum of AIP gene mutations has been identified in familial and sporadic pituitary adenomas (PA) with over 70 different mutations described to date. c.47G>A, p.R16H is an AIP exon 1 variant of unknown significance, its contribution to pituitary adenoma development being controversial.Aim: Characterization of p.R16H prevalence in a large Romanian cohort of PA patients and controls.Patients and methods: spo...