Searchable abstracts of presentations at key conferences in endocrinology

ea0014p603 | (1) | ECE2007

Growth hormone deficiency in patients with acromegaly after ‘successful’ transsphenoidal surgery

Petakov Milan , Isailovic Tatjana , Djurovic Marina , Macut Djuro , Joksimovic Miloje , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

The diagnosis of adult growth hormone deficiency (GHD) in patients with pituitary disease relies predominantly on provocative tests of GH secretion. The incidence of GHD in treated acromegalic patients has not been fully documented. Therefore, the aim of the present study was to elucidate GH response to insulin-induced hypoglycaemia (ITT, 0.15 IU/kg i.v.) in a cohort of 10 patients with acromegly considered cured solely by transsphenoidal surgery (6 females and 4 males, mean a...

ea0056gp7 | Acromegaly | ECE2018

Familial cancer clustering in patients with pituitary adenoma

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Popovic Vera

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

ea0081ep215 | Calcium and Bone | ECE2022

Pregnancy and lactation-associated osteoporosis

Jemuovic Zvezdana , Djurovic Marina Nikolic , Djurdjevic Sandra Pekic , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Petakov Ana , Petakov Milan

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

ea0063p1112 | Pituitary and Neuroendocrinology 3 | ECE2019

Metabolic phenotype in acromegaly

Djurdjevic Sandra Pekic , Prpic MIlica , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Jemuovic Zvezdana , Djurovic Marina Nikolic , Petakov Milan

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

ea0049gp188 | Pituitary & endocrine Tumours | ECE2017

Vertebral fractures are prevalent among patients with acromegaly in spite of normal bone mineral density reflecting overall duration of disease regardless of biochemical control or cure

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Djurovic Marina Nikolic , Jemuovic Zvezdana , Popovic Vera , Petakov Milan

Introduction: Skeletal complications of acromegaly are among its most persistent and invalidating impacts. Dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading for bone health assessment in acromegaly.Patients and methods: Patients with acromegaly (N=170) were classified as active (N=104), operatively cured (N=34) or medically controlled (N=32). 57 males and 113 females were included, 52.8 (22...

ea0035p625 | Female reproduction | ECE2014

Prevalence of dysglycaemia in obese women with polycystic ovary syndrome

Bjekic-Macut Jelica , Antic Ivana Bozic , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Kastratovic-Kotlica Biljana , Petakov Milan , Ilic Dusan , Macut Djuro

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

ea0016p340 | Endocrine tumours | ECE2008

Insulin sensitivity in a patient with gastric ghrelinoma

Popovic Bojana , Bozic Ivana , Macut Djuro , Lalic Nebojsa , Jotic Aleksandra , Djuranovic Srdjan , Isailovic Tatjana , Petakov Milan , Damjanovic Svetozar

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...

ea0016p361 | Growth and development | ECE2008

Changes in cortisol and insulin during pregnancy in relation to basal metabolic rate (BMR)

Damjanovic Svetozar , Stojic Rada , Lalic Nebojasa , Petakov Milan , Jotic Aleksandra , Isailovic Tanja , Popovic Bojana , Macut Djuro , Bozic Ivana

Cortisol rise during pregnancy is connected with fetal maturation. Together with the increase of insulin resistance it might have a role in allocation of nutrients between mother and fetus. Cortisol and insulin secretion during pregnancy seems to be induced by fluctuations in BMR. Here, we try to identify relationship between BMR and secretion of cortisol and insulin during pregnancy.In 25 healthy women (age range 20–39 years; mean±S.D.<...

ea0014p177 | (1) | ECE2007

Screening for mutations in exon 10, 11, 13 and 14 of the RET protooncogene associated with inherited medullary thiroid carcinoma (MTC) in Serbian population

Nikolic Jelena , Vignjevic Jovana , Mirkovic Katarina , Beleslin-Cokic Bojana , Antic Jadranka , Isailovic Tatjana , Petakov Milan , Damjanovic Svetozar

Background: Ret protooncogene germ-line mutations are associated with the inherited multiple endocrine neoplasia type 2 syndromes (MEN2a and MEN2b) and also with familial medullary thyroid carcinoma (FMTC). In this study, we report a large scale of mutations in exon 10, 11, 13 and 14 RET protoocogene in patients from Serbia. Our study included patients with MTC.Methods: Our study included 180 patients. Patients were tested for RET protooncogene mutations...

ea0014p516 | (1) | ECE2007

Composite medullary and papillary tumor with mixed lymph node metastases

Isailovic Tatjana , Petakov Milan , Macut Djuro , Popovic Bojana , Bozic Ivana , Ognjanovic Sanja , Nikolic Jelena , Vignjevic Jovana , Mirkovic Katarina , Damjanovic Svetozar

A 34 year-old female patient was admitted to the hospital because of a large nodule in the left thyroid lobe and elevated calcitonine level. A large encapsulated tumor was found and total thyroidectomy with left neck dissection was performed. Pathohistology revealed medullary and papillary carcinoma separate from each other in tumor tissue but mixed in regional lymph nodes. Papillary component was dominant in thyroid tissue but not in lymph nodes. Both calcitonine and thyroglo...