Searchable abstracts of presentations at key conferences in endocrinology

ea0014p517 | (1) | ECE2007

Management of endocrine syndrome in a patient with plurihormonal neuroendocrine tumour

Popovic Bojana , Macut Djuro , Bozic Ivana , Isailovic Tatjana , Petakov Milan , Ognjanovic Sanja , Mirkovic Katarina , Vignjevic Jovana , Damjanovic Svetozar

Neuroendocrine tumours (NETs) have a unique ability to produce and secrete a variety of biogen amines and peptide hormones. They arise from multipotential stem cells, which differentiate during tumorigenesis into specific cell lines. Some of these tumours are functional, producing characteristic clinical syndromes. We present a female patient incidentally discovered to have diffuse liver metastases of neuroendocrine tumour of unknown primary origin. She was free of symptoms at...

ea0056p498 | Diabetes therapy | ECE2018

Cognitive status, anxiety and depression in patients with type 2 diabetes mellitus on selective DPP4 inhibitor therapy

Djurovic Marina Nikolic , Jemuovic Zvezdana , Vasovic Olga , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Djokic Biljana Salak , Krljanac Gordana , Petakov Milan

Introduction: Cognitive functions and mood (anxiety and depression) are often impaired in diabetes mellitus (DM). Dipeptidyl peptidase-4 inhibitor (DPP-4) has been shown to exert beneficial effects on insulin sensitivity and glycoregulation in T2DM patients. Introducing DPP-4 therapy leads to maintaining control of glucose levels which could ameliorate or slow down further cognitive and mood disorders impairment.Aim: To evaluate influence of selective DP...

ea0081ep649 | Pituitary and Neuroendocrinology | ECE2022

Lipid accumulation product (LAP) as surrogate marker of fatty liver in patients with Cushing’s disease (CD)

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Radovic Sara , Radić Nevena , Petakov Milan

Introduction: The most common etiology of endogenous Cushing’s syndrome (CS) is Cushing’s disease (CD). Patients with CS also represent a model of patients with metabolic syndrome (MetS) with associated increased cardiovascular morbidity and mortality. Insulin resistance and obesity, two major characteristics of CS, lead to the accumulation of triglycerides within hepatocytes and formation of fatty liver in these patients.Aim: To evaluate the p...

ea0081ep670 | Pituitary and Neuroendocrinology | ECE2022

Xantho-granulomatous hypophysitis: analysis of clinical, biochemical, radiological and etiological characteristics

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Milojevic Toplica , Milicevic Mihailo , Gacic Emilija Manojlovic , Jovanovic Jovan , Medenica Sanja , Petakov Milan

Introduction: Xanthomatous hypophysitis (XH) is characterized by inflammatory infiltration of the pituitary gland in which lipid laden macrophages predominate. It can be primary (3% of all primary hypophysitis) and secondary arising in the setting of other lesions: craniopharyngioma, Rathke’s cleft cyst (RCC), adenomas (with subclinical apoplexy). It is more common in women and younger people. The clinical presentation is similar to pituitary tumors and may prese...

ea0081ep761 | Pituitary and Neuroendocrinology | ECE2022

Skeletal complications in Cushing’s disease (CD)

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Radić Nevena , Radovic Sara , Petakov Milan

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushing’s disease, as well as gain insig...

ea0067gp37 | Poster Presentations | EYES2019

Calcium infusion test in primary hyperparathyroidism- sensitivity of calcium sensing receptor, possible new theories?

Muzurovic Emir , Pekic Sandra , Djurovic Marina , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Jemuovic Zvezdana , Vujošević Snežana , Šahmanović Benida , Petakov Milan

Objective: Ionized calcium via calcium sensing receptors (CaSR) mediates feedback inhibition of parat hormone (PTH) secretion. The aim of this study is to evaluate the difference in PTH response during calcium infusion test (CIT), between patients with primary hyperparathyroidism (PHPT) and healthy control (HC).Methods: Study consisted of 15 patients with confirmed PHPT and parathyroid adenoma (57.20±11.38yrs) and 15 healthy subjects-HC (57.20±...

ea0063p236 | Pituitary and Neuroendocrinology 1 | ECE2019

Serum aryl hydrocarbon receptor-interacting protein (AIP) levels are independent of serum GH levels both at baseline and in dynamic tests of GH stimulation and suppression

Stojanovic Marko , Wu Zida , Stiles Craig , Miljic Dragana , Soldatovic Ivan , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera , Strasburger Christian , Korbonits Marta

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

ea0049gp197 | Thyroid 1 | ECE2017

Cognitive functions in primary hypothyroidism on selenium supplementation

Nikolic-Djurovic Marina , Pereira Alberto , Smit Johannes , Vasovic Olga , Jemuovic Zvezdana , Damjanovic Svetozar , Asanin Milika , Pavlovic Dragan , Jankovic Dragana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Petakov Milan

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...

ea0049ep80 | Adrenal cortex (to include Cushing's) | ECE2017

The effect of subclinical hypercortisolism on bone mineral density in female patients with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Petakov Milan , Elezovic Valentina Kovacevic , Isailovic Tatjana , Antic Ivana Bozic , Ilic Dusan , Popovic Bojana , Bogavac Tamara , Antic Jadranka , Damjanovic Svetozar

To investigate the prevalence of SH and osteoporosis in female patients with unilateral AIs (UAIs) and bilateral AIs (BAIs).We enrolled 106 female patients, 68 (64.2%) with UAIs and 47 (35.8%) with BAIs. SH was diagnosed in the presence of serum cortisol levels after 2-day low-dose dexamethasone suppression test (LDDST) >50 nmol/l with at least one of the following parameter (midnight serum cortisol >208 nmol/L, 24-h urinary free cortisol >24...

ea0049ep177 | Endocrine tumours and neoplasia | ECE2017

Pancreatic neuroendocrine tumors (PNETs) in patients with MEN1 syndrome

Isailovic Tatjana , Macut Djuro , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Milicevic Ivana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

PNETs represent the leading cause of mortality in MEN1 patients. Yet, their characteristics, behaviour, and therefore management, are still uncertain.The aim of this study was to describe the main clinical characteristics of NETs in MEN1, and to compare them with sporadic NETs.We investigated 164 patients with PNETs retrospectively, treated in one centre from 2004–2016. We identified 15 (9.1%) patients with MEN1. All patients ...