Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

ea0049ep954 | Pituitary - Clinical | ECE2017

Changes in pituitary tumour biology and behaviour in FIPA patient with GH secreting aggressive pituitary macro adenoma

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Nikolic-Djurovic Marina , Stojanovic Marko , Manojlovic-Gacic Emilija , Korbonits Marta , Trouillas Jaqueline , Vasiljevic Alexandre , Popovic Vera , Petakov Milan

40-year-old female patient presented with acromegaly in 2008 (GH 61 (g/L, IGF-1 774 ng/ml PRL 1500 mU/L). Macro-adenoma invading the right cavernous sinus was found on MRI and she underwent two pituitary surgeries revealing sparsely granulated GH adenoma with scattered PRL cells, low Ki 67 and negative p53 immuno-staining. Her second cousin was treated for macro prolactinoma. Both patients tested negative for germline mutations in the AIP and menin genes. Treatment with somato...

ea0049ep956 | Pituitary - Clinical | ECE2017

Rare causes of hypopituitarism in adults in a tertiary care institution

Djurdjevic Sandra Pekic , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Stojanoska Milica Medic , Popovic Vera , Petakov Milan

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

ea0041ep735 | Neuroendocrinology | ECE2016

Phenotype-genotype analysis in patients with GnRH deficiency in a single center

Djurdjevic Sandra Pekic , Xu Cheng , Dwyer Andrew , Cassatella Daniele , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Pitteloud Nelly , Popovic Vera

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

ea0037eyes1.4 | Sex, drugs and rocking hormones | ECE2015

Hypothalamo-pituitary-adrenal axis response and adaptation to repeated physical stress in professional athletes

Popovic Bojana , Popovic Dejana , Macut Djuro , Antic Ivana Bozic , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Ilic Dusan , Antic Jadranka , Petakov Milan , Damjanovic Svetozar

Activation of hypothalamo-pituitary-adrenal (HPA) axis is a common feature of endocrine responses to stress, with cortisol secretion as an end product of this activation. Acute rise in cortisol level during stress is of utmost importance for metabolic adjustments, immune system adaptations, cardiovascular responses and muscle tissue remodeling. But since chronic hypercortisolism has many deleterious effects, scientific interest has started focusing around different biological ...

ea0037ep1136 | Endocrine tumours | ECE2015

Clinical characteristics and survival of patients with adrenocortical carcinoma: a single centre experience

Elezovic Valentina , Macut Djuro , Petakov Milan , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Adrenocortical carcinoma (ACC) is rare malignancy associated with limited treatment options and poor prognosis. The aim of this study is to review clinical characteristics and survival of patients with ACC in single centre. We retrospectively analysed 60 patients (37 female and 23 males) with pathologically confirmed ACC who were treated at our institution between January 2005 and December 2014. Staging was performed according to European Network Study of Adrenal Tumours (ENS@...

ea0037ep1141 | Endocrine tumours | ECE2015

Genotype–phenotype analysis in patients with medullary thyroid carcinoma: a single centre experience

Isailovic Tatjana , Rodic Gordana , Macut Djuro , Petakov Milan , Ognjanovic Sanja , Elezovic Valentina , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Introduction: Medullary thyroid carcinoma (MTC) is a malignant neoplasm derived from the parafollicular cells of the thyroid gland. Approximately 25% of them are caused by germline mutations of the RET gene, presenting as a part of FMTC, MEN2A or MEN2B syndrome.Design of the study: We analysed 213 consecutive patients with MTC (142 females, 71 males, age 6–78, mean 45 years), treated in a single centre from 2004 to 2014. Direct DNA sequenci...

ea0035p299 | Clinical case reports Thyroid/Others | ECE2014

Breast cancer in multiple endocrine neoplasia type 1

Elezovic Valentina , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Milicevic Ivana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant familial tumor syndrome characterised by varying combinations of endocrine and non-endocrine tumors. Breast cancer is the most frequently diagnosed cancer in women, but presence of breast cancer in MEN1 is extremely rare.A 36-year-old patient has been diagnosed with primary hyperparathyroidism, breast cancer and hyperprolactinemia due to a pituitary macroprolactinoma. Treatment ...

ea0035p313 | Clinical case reports Thyroid/Others | ECE2014

Ectopic co-secretion of growth hormone and growth hormone-releasing hormone from a neuroendocrine lung tumor in a patient with MEN1 syndrome

Isailovic Tatjana , Todorovic Vera , Milicevic Ivana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Skender-Gazibara Milica , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

The co-secretion of GHRH and GH has been described previously in a patient with GHRH producing pituitary somatotroph adenoma. Here we present a patient with MEN1 and ectopic secretion of both GHRH and GH from a neuroendocrine lung tumor.A 52-year-old woman was diagnosed in 2009 with two lung tumors, 4 cm right upper lobe tumor, and 2 cm left lower lobe tumor. Owing to a mild coarsening of facial features, acromegaly was suspected. Endocrine studies showe...

ea0035p548 | Endocrine tumours and neoplasia | ECE2014

Efficacy and safety of transarterial chemoembolization of unresectable neuroendocrine liver metastases

Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Isailovic Tatjana , Macut Djuro , Popovic Bojana , Bogavac Tamara , Bozic Ivana , Ilic Dusan , Colic Momcilo , Damjanovic Svetozar

Background: Trans-catheter arterial chemoembolization (TACE) is a method of treatment of unresectable liver metastases from neuroendocrine tumours (NETs) which is effective in the control of symptoms and tumour growth.Aim: To evaluate clinical outcome: radiologic, biologic, symptomatic response and safety of TACE procedure.Method: 31 patients underwent 140 TACE procedures during 2003–2011. Tumour responses were measured by CT ...