Searchable abstracts of presentations at key conferences in endocrinology

ea0020p43 | Adrenal | ECE2009

Iatrogenic Cushing’s syndrome induced by topical corticoid application in child and adult

Branisteanu Dumitru , Turliuc Serban , Veliaj Blenda , Mogos Simona , Zbranca Eusebie , Repede Ionut , Aancute Adrian , Mogos Voichita

Topical application of corticosteroids is frequently used in the therapy of dermatological diseases due to their anti-inflammatory and immunosuppressive effects. On the other hand, when reaching pharmacological levels, exogenous corticoids frequently lead to complete Cushing syndrome, including skin modifications, irrespective of the route of administration. We describe four cases of iatrogenic Cushing’s syndrome triggered by topical application of corticoids. The first t...

ea0020p309 | Clinical case reports and clinical reports | ECE2009

A case of giant-cell jaw tumour and primary hyperparathyroidism

Mogos Voichita , Popescu Eugenia , Popa Teodora , Stefanescu Cipriana , Zbranca Eusebie , Grigorovici Alexandru , Mihailovici Sultana , Branisteanu Dumitru

Patient DE, a 49-year-old woman, was operated in 2005 for two giant-cell tumours of the mandible, and in 2008 for another tumour with the same localisation and histology. Inferior cervical ultrasound after the second surgery revealed a parathyroid adenoma of 20×27×15 mm behind the lower pole of the right thyroid lobe, confirmed by Tc tetrofosmin scintigraphy. The patient had metabolic features suggestive for primary hyperparathyroidism: calcium – 10.9 mg/dl (nor...

ea0016p769 | Thyroid | ECE2008

The influence of chronic GH excess upon thyroid gland morphology evaluated by ultrasound

Buzduga Catalin , Ananie Teodora Emiliana , Mogos Simona , Zbranca Eusebie , Galesanu Corina , Mogos Voichita , Branisteanu Dumitru D

It is known that thyroid pathology is generally more frequently found in women than in men. The somatotroph axis stimulates skeleton growth, but also the development of smooth tissues, including the thyroid gland. We investigated the effect of chronic GH excess upon ultrasound-evaluated (7.5 MHz linear probe) thyroid gland morphology of 74 patients (40 women şi 34 men) diagnosed with acromegaly. When compared to mean thyroid volume of age- and sex-matched non-acromegali...

ea0014p180 | (1) | ECE2007

Lower catch-up growth under rGH therapy at pre-pubertal pituitary dwarves diagnosed at an older age

Branisteanu Dumitru , Galesanu Corina , Cristea Cristina , Zbranca Eusebie , Vulpoi Carmen , Preda Cristina , Mogos Voichita

Growth hormone deficiency leads to profoundly decreased growth velocity and, when untreated, to pituitary dwarfism. We evaluated growth evolution for one to four years under rGH therapy (0.07 IU/kg/day, subcutaneously) at seventeen idiopathic pituitary dwarves with isolated GH deficiency, 13 boys and 4 girls, with a wide span of age at therapy onset (between 4 and 24 years old). Diagnosis was set subsequent to at least two negative GH stimulation tests. All patients were pre-p...

ea0014p477 | (1) | ECE2007

Thyroid dysplasia – 30 cases of lingual thyroids

Zbranca Eusebie , Preda Cristina , Mogos Voichita , Leustean Letitia , Vulpoi Carmen , Galusca Bogdan , Rusu Valeriu , Negru Radu

Thyroid dysplasia (ectopy, hypoplasia or aplasia) is a common cause of congenital hypothyroidism. Lingual thyroid is a rare embryological aberration caused by failure of migration of the thyroid gland to its normal position in the neck.This retrospective study involved 30 patients with lingual thyroid diagnosed in our Department between 1970–2005. The diagnosis was based on physical examination, evaluation of the mental development (IQ) and following tests:TSH, fT4, ultra...

ea0049ep213 | Bone & Osteoporosis | ECE2017

Primary hyperparathyroidism: hormonal profile and risk of complications

Gatu Alina-Andreea , Velicescu Cristian , Preda Cristina , Mogos Voichita , Vulpoi Carmen , Mogos Simona , Zaharia Valentin , Aancute Adrian , Branisteanu Dumitru

Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We ...

ea0049ep260 | Calcium & Vitamin D metabolism | ECE2017

How to differentiate primary hyperparathyroidism with D hypovitaminosis from secondary hyperparathyroidism due to D hypovitaminosis?

Gatu Alina-Andreea , Velicescu Cristian , Preda Cristina , Vulpoi Carmen , Mogos Simona , Mogos Voichita , Zaharia Valentin , Aancute Adrian , Branisteanu Dumitru

Background: D hypovitaminosis and primary hyperparathyroidism frequently coexist. Secondary hyperparathyroidism reactive to D hypovitaminosis is difficult to be differentiated from primary hyperparthyroidism.Aims: To differentiate patients with D hypovitaminosis and secondary hyperparathyroidism.Materials and methods: Prospective study involving 71 patients admitted in our department for 1 year with the initial diagnosis of primary...

ea0049ep1076 | Pituitary - Clinical | ECE2017

Pituitary adenoma and elevated ACTH: not always corticotrophinoma

Cabac Mariana , Belceanu Alina Daniela , Crumpei Iulia , Tirnovan Mirela , Constantinescu Georgiana , Bursuc Anamaria , Constantinescu Aurora , Mogos Voichita , Vulpoi Carmen

Introduction: Hypothalamic–pituitary–adrenal (HPA) axis activation is the main neuroendocrine response to an environmental challenge. Drug abuse may activate HPA axis by interaction with neuromodulation systems.Case report: 28 year old man, was admitted in the Neurology Department for persistent headache with spinal irradiation. With suspicion of multiple sclerosis, MRI revealed pituitary macroadenoma (14 mm diameter) and subcortical, paraventr...

ea0049ep1209 | Clinical case reports - Thyroid/Others | ECE2017

Autoimmune thyroid disease occurring as a possible late complication after a non-occupational HIV Postexposure Prophylaxis

Crumpei Iulia , Mogos Voichita , Ungureanu Maria-Christina , Bursuc Anamaria , Armasu Ioana , Tirnoveanu Mirela , Adomnicai Valentina , Constantinescu Georgiana , Vulpoi Carmen

Introduction: Nonoccupational postexposure prophylaxis (nPEP) is a three-drug antiretroviral regimen used to decrease the risk for HIV infection after less than 72 h from nonoccupational exposure to body fluids that might contain HIV. The most frequent side effects concern the gastro-intestinal intolerance, renal and hepatic toxicity, with no hormonal imbalance to have been yet reported.Case report: 24 years old male patient, consulted for palpitations, ...

ea0041ep337 | Clinical case reports - Thyroid/Others | ECE2016

Management dilemma in papillary carcinoma arising from struma ovarii

Hreniuc Ana , Gherasim Simona , Preda Cristina , Ungureanu Maria-Christina , Vulpoi Carmen , Mogos Voichita , Piciu Doina , Danila Radu , Leustean Letitia

A rare ovarian teratoma consisting mainly of thyroid tissue, Struma ovarii accounts for up to 3% of all ovarian tumors. The thyroid tissue may demonstrate the same spectrum of pathological features as in the normal thyroid including benign and malignant changes.A 46-year-old woman was referred to our clinic in July 2015 by the oncologist, with the diagnosis of struma ovarii with carcinomatous transformation (follicular variant of papillary carcinoma).</p...