Endocrine Abstracts

Background: Patients undergoing thyroid surgery are consented for a 1% risk of permanent hypocalcaemia and voice changes. These complications are considered to be permanent if they persist for more than 6 months. The aim of this study is to determine the incidence of complications in patients undergoing thyroid surgery in our hospital.Methods: From January 1999 to March 2009, all patients who underwent thyroid surgery under the care of one surgeon were i...

Even though it is unusual, many cases presenting with combinations of thyroid carcinomas have been reported. Concurrent occurances of medullary – papllary carcinoma, follicular – papillary – medullary carcinoma, follicular – anaplastik – papillary carcinoma, papillary – follicular carcinoma have been presented. The cases reported up to now had no thyroid autoimmunity. We present a case with known Hashimoto’s thyroiditis having a combination o...

Endokinin B (EKB) is a recently identified tachykinin whose role is not yet fully understood. EKB displays equivalent affinity for the three tachykinin receptors as substance P (SP) which it is often found co-expressed with. SP has been implicated in a variety of neuroendocrinological responses including stress regulation, and affective and anxiety-related behaviours. An important aspect, therefore, is to dissect a distinct role for EKB from that of SP. Here, we have attempted...

We report two cases of seizures resulting from severe electrolyte imbalance.Case 1: A 48-year old lady with CREST syndrome and oesophageal dysmotility. She was admitted with diarrhoea and vomiting. Routine investigations including FBC, U&E, LFT, and CRP were normal. She later complained of pins and needles in her hands and around her mouth. Twenty-four hours later, she developed blurred vision, neck pain and generalised ache, was found drowsy, with p...

Deficient production of thyroid hormones in maternal organism may have a drastic impact on brain development of the offsprings. Among the people originated from the regions with essential deficiency of iodine in foodstuff there is a high chance for prevalence of mental retardation and neurological cretinism with all possible complications.The present study analyses changes in emotional state (open field testing), learning ability and memory processes (ma...

Introduction: In endocrine tumours, such as that of the breast, the protein survivin has emerged as a unique regulator of cell death. We have previously shown that bFGF regulates survivin expression through the MAP kinase cascade. The transcriptional complex myc/max is an oncogene that lies downstream of the MAP kinase pathway suggesting a possible role in survivin's regulation.Aim: To determine if bFGF can mediate survivin expression by signalling throu...

A 64 year-old woman was referred because of male pattern baldness and hirsutism. There were no virilizing or Cushingoid features and no abnormalities on gynaecological assessment.Investigations: Testosterone 7.4 nmol/L [0-2.4], FSH 81.0 iu/L, LH 38.3 iu/L, 17 Alpha hydroxyprogesterone 11.0 nmol/L [0-10], Free androgen index 21.1 [0-7.5], DHEA sulphate 1.9 micromol/L [2.2-10.0], urine free cortisol less than 150 nmol/24 hrs. Chest x-ray normal, abdominal and pelvic ultrasou...

Objective:The clinical observations suggest that there is statistically significant correlation between Diabetes Mellitus(DM)type and the type of treatment on one hand, and the average duration of occurence of the chronic complications on the other hand.Material and Methods:The studied groups comprised that 1315 subjects who represent all the patients suffering from Diabetes Mellitus(DM),under the observation of Diabetic Center in Oradea.<p class="ab...

Objective:The clinical observations suggest that there is statistically significant correlation between Diabetes Mellitus(DM)type and the type of treatment on one hand, and the average duration of occurence of the chronic complications on the other hand.Material and Methods:The studied groups comprised that 1315 subjects who represent all the patients suffering from Diabetes Mellitus(DM),under the observation of Diabetic Center in Oradea.<p class="ab...

Objective To evaluate the prevalence of insulin resistance and metabolic syndrome, to define its components and to reveal their relationships in obese children. Patients and methods A total of 147 obese (BMI higher than 95 centile for age and gender) Caucasian children aged 9-16 years, mean age 13,67±2,43 (75 boys and 72 girls) were examined. Waist and hip circumferences were measured with WHR calculation, arterial blood pressure was registered. Standard 2-h OGTT was pe...