Endocrine Abstracts

BACKGROUND Recent evidence has suggested that minor degrees of thyroid dysfunction are associated with adverse outcomes and this argues for tight control of thyroid hormone replacement. Thyroxine (T4) tablets are available in 25, 50 and 100 microgram strengths in the UK but some patients require doses which cannot be obtained with these strengths. We have examined data from a thyroid register to determine the proportion of patients whose mean daily T4 dose cannot be achieved w...

MEN1 germline mutations are identified in 70% of the familial forms of MEN1 and about 10%of the sporadic cases. Little is known about clinical differences between MEN1 with and without identification of MEN1 germline mutation particularly in terms of PA characteristics.Aim: To compare the clinical features of PA in MEN1 cases with and without germline MEN1 mutation and sporadic cases of PA. Patients and methods: Data were obtained in...

Background: Hypopituitarism after cranial radiotherapy for non-pituitary tumors is well recognized. However structured endocrine assessments are not incorporated into routine clinical practiceAim of the study: To evaluate pituitary function in adult patients irradiated for non-pituitary tumors at our centerPatients and Methods: Cross-sectional evaluation of pituitary function of all available patients treated with irradiation at ou...

Introduction: Subclinical hypothyroidism and euthyroid thyroiditis have in common the clinically asymptomatic character. These two diseases can occur during pregnancy with no clinical impact.Our objectives are:– Prevalence of subclinical hypothyroidism during the 1st trimester of pregnancy.– Frequency of autoimmunity in euthyroid pregnant women in 1st quarter.– Analysis o...

Introduction: Hyperthyroidism affects 2 to 3% of pregnant women. The prevalence of clinical hyperthyroidism during pregnancy is variously appreciated. Hyperthyroidism prior to pregnancy is probably more common than in connection with the gestationnal state as gestational hyperthyroidism usually blocks fertility. Our objectives are the prevalence and the causes of hyperthyroidism in pregnant women in the 1st quarter.Description of methods: Prospective stu...

Introduction: The maternal hypothyroxinemia would be an adaptive process of the thyroid gland to iodine deficiency, regardless of the TSH. Our objectives are the prevalence and pathophysiological approach of hypothyroxinemia in pregnant women in the 1st quarter.Description of methods: Labor-looking statements, made in Oran area, on 270 pregnant women in 1st quarter. Women who smoke (active smoking confessed) and those followed for thyroid disease or taki...

Introduction: Two insulin regimes are commonly used in type 1 diabetes (T1D): twice daily (BD) premixed insulin (short and intermediate acting), and multiple daily injections (MDI) of short acting insulin with once daily bolus of long acting insulin. MDI is associated with better glucose control in adults, but the evidence base is weaker for children.Objectives: We aimed to compare children started on MDI to BD from diagnosis, on HbA1c as a measure of gl...

Glomus jugulare tumours are rare and often difficult to manage. A small proportion of these tumours (1–3%) can cause symptoms due to catecholamine secretion. Here we describe a patient with secretory glomus jugulare tumour treated with steriotactic radio surgery and its effect on catecholamine secretion.Case report: A 39-year-old lady was referred to ear specialists with the characteristic symptoms of pulsatile tinnitus and decreased hearing in the ...

Mutations in the HSD11B2 gene explain the syndrome of apparent mineralocorticoid excess (AME), which is characterised by severe hypokalaemic hypertension. Cortisol acts as a mineralocorticoid through failure of its inactivation to cortisone by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). Patients are diagnosed by a raised THF+allo-THF/THE ratio. To date, approximately 30 mutations have been described in HSD11B2. Recently, three apparently unrelated kindreds with A...

Background: Primary thyroid angiosarcoma (PTA), previously considered a vascular type of anaplastic thyroid carcinoma (ATC), is a rare, aggressive malignant mesenchymal tumor, with a peak incidence in the seventh decade of life. PTA can present as an ATC, a more frequent type of thyroid malignancy. Differential diagnosis is of major importance, as the management and prognosis differ significantly.Case report: A 72-year-old woman presented for a 2 month h...