Endocrine Abstracts

Introduction: The combination of hypokalemia and hypercalcaemia is uncommon but potentially lethal. In primary hyperparthyroidism hypokalaemia most commonly occurs due to incomplete distal renal tubular acidosis. We present the first case of simultaneous primary hyperparathyroidism with Gitelman’s syndrome resulting in profound electrolyte imbalance.Case: A 48-year old man, referred with hypokalaemia (2.5 mmol/l) presented with a short history of ex...

The functional oxytocin (OT) system is present in the heart and stimulate cardiomyocyte (CM) differentiation of embryonic stem cells. Presently, we are reporting that the OT stimulates CM differentiation of stem cells isolated from the rat heart and termed as side population cells (SP). Specifically, the phenotype of SP-CD31(−) cells, but not SP-CD31(+) cells, proliferate in the presence of OT; the OT treatment promote cell aggregation, and then stimulate differentiation...

We have audited control of acromegaly in a specialist endocrine unit in Oxford now that this should usually obtainable. We have 240 patients under active surveillance, seen annually since diagnosis. Data from 115 of these seen in the last year have been used for this analysis.Methods: We grouped patients according to whether they were controlled in either or both IGF1 and GH or uncontrolled. Controlled IGF1 was defined according to age and sex and GH was...

Introduction: Hypoglycaemia in a non-diabetic patient is not a common condition and is often a diagnostic challenge.Case report: A 78-year-old gentleman was admitted to hospital by paramedics when his neighbours found him unresponsive. He had a background history of primary hypothyroidism. Capillary blood glucose reading done on site was 1.0 mmol/l. He received intravenous glucose which resulted in prompt recovery. All other vital signs were normal.<...

Introduction: Hypercalcaemia is a frequent complication of breast cancer with bony metastasis. There is also an increase incidence of primary hyperparathyroidism among patients with breast cancer. We report a patient with breast cancer presenting with hypercalcaemia secondary to both parathyroid hormone- related peptide (PTHrP) from liver metastasis and possibly co-existing primary hyperparathyroidism.Case report: A 53 year old woman, with a history of r...

A 28 year old female with no significant medical history, 25 weeks into her second pregnancy was referred to endocrinology with adjusted calcium of 2.99 mmol/l. She had a short history of generalised aches and tiredness. Examination did not reveal any stigmata of MEN1 or the HPT-JT syndromes. There was no known family history of endocrine disorders. Her PTH was 7 pmol/l, confirming primary hyperparathyroidism. As parathyroid Tc-scintigraphy would be contraindicated in pregnanc...

Introduction: Muslims including many patients with diabetes mellitus practice dawn to sunset fasting during the month of Ramadan. Using CGM recorded data we have investigated glucose excursions with Ramadan fasting in a group of patients with type 2 diabetes mellitus and good glycaemic control.Methods: Thirty-four patients with type 2 diabetes mellitus (8 female, 26 male, age 46.5±11.1 years, HbA1c 6.9±1.0%, BMI 29.5±6.5 kg/m2) ...

Objectives: Oral administration of vanadate to diabetic animals have been shown to stabilize the glucose homeostasis and restore altered metabolic pathways. The present study explored the prospect of using low doses of vanadate with Trigonella foenum graecum, seed powder (TSP), another antidiabetic agent, and to evaluate their antidiabetic effect in diabetic rats. The effect of these antidiabetic compounds was examined on general physiological parameters, monoamine oxidase act...

Background: Health numeracy is the ability to understand, and act upon quantitative data, in an appropriate and effective manner. Health numeracy is distinct from health literacy. Health numeracy is associated with better self-management.Aims and objectives: This study was performed at two endocrine centres in north India, to assess and improve the health numeracy of patients with type 2 diabetes, with an aim to improving the quality of shared decision m...

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...