Endocrine Abstracts

Introduction: Insulin resistance is a main characteristic of polycystic ovary syndrome (PCOS) and contributes to the increased risk of type 2 diabetes and cardiovascular disease. It is thought that in PCOS there is an alteration in the insulin signaling pathway. An important kinase in this pathway is the phosphatidylinositol 3 kinase (PI3K), the activity of which has been found to be decreased in PCOS. Based on this observation we investigated whether a single nucleotide polym...

Introduction: Increased oxidative stress is considered to be implicated in the pathophysiology of polycystic ovary syndrome (PCOS). While the regulation of oxidative stress is multifactorial, many studies have been focused on the antioxidant role of paraoxonase (PON). The aim of this study was to investigate the possible association of the Q192R and the L55M polymorphisms of PON1 and the Ser311Cys polymorphism of PON2 with PCOS.Subjects and...

Background: Surgery remains the mainstay of treatment for both benign and malignant thyroid disease. Permanent hypoparathyroidism and recurrent laryngeal nerve injury are the two most commonly occurring complications post thyroid surgery. The aim of this study is to determine the risk factors for developing post-operative complications.Methods: From January 1999 to March 2009, all patients who underwent thyroid surgery under the care of one surgeon were ...

Background: Radioiodine (RI) treatment of benign thyroid disease in young people has received a lot of attention recently with authorities in the US highlighting an encouraging short and medium term safety record. In this audit we surveyed treatment centres in the UK to assess the trend in RI administration in patients aged 21 years and under.Methods: Over sixty Medical Physics Departments, dispersed to represent a suitable geographical coverage pattern ...

We present the case of a 62 year old gentleman who was diagnosed with Acromegaly in 1998.He commenced testosterone replacement therapy in the form of Sustanon every three weeks in October 2000 following a testosterone level of 6.6 nmol/l.PSA levels during treatment with Sustanon were: 01/03/01–5.1μg/l.06/04/01–4.9 μg/l at which point he was referred for a urological opinion.<p class="a...

Arunachal Pradesh is one of the north eastern provinces of India situated on the Eastern Himalayan mountain range. Enriched with diversified flora, fauna and ethnic population, this zone has been recognised as one of the world’s Mega Biodiversity hot spots. The people of this state use bark powder of a plant Dysoxylum alliarium for pregnancy control of mated females especially dogs and pigs.Objective: Validation of this bark’s abortifaci...

Piper betuloids is a creeper grown wildly in the tropical forests of the north east part of India. The ethnic people of this region, especially in Arunachal Pradesh use the secondary roots of this creeper for fertility control in women. The traditional preparation has been reported to be use orally during post coital period.Objectives: The anti-reproductive property of the secondary aerial roots has been tested on female albino rats during early g...

Introduction: We have recently presented data demonstrating total body and regional bone mass relative to body size is reduced in obese children. Adipokines have been shown to play a role in bone metabolism. We hypothesised that 1) increased bone turnover would be associated with reduced bone mass 2) increased serum leptin would be associated with increased osteoclastogenic factors 3) reduced adiponectin woul...

Chronic pancreatitis (CP) may lead to deficiency of fat soluble vitamins such as vitamin D; little is known of the extent of this in chronic pancreatitics.In order to assess the extent and severity of vitamin D deficiency in CP we examined the notes of 111 patients with CP. In addition to clinical information and calcium, vitamin D and PTH levels, exocrine function was evaluated using the PABA test to obtain a pancreatic excretion index (PEI: normal &#62...

Nebido (testosterone undecanoate 1000 mg injection) was used to induce pubertal development in 2 apubertal men with Kallmann’s syndrome, in their 6th decade.Case 1: Originally diagnosed with Kallmann’s syndrome aged 21, but then discontinued treatment for the next 25 years. Now aged 50, he was markedly eunuchoid: G3-4, P3, A1.Investigations: Testosterone 1.0 nmol/l, LH and FSH <0.5IU/l.Normal fe...