Searchable abstracts of presentations at key conferences in endocrinology

ea0029p567 | Diabetes | ICEECE2012

Clinical and histopathology tumor characteristics of patients with invasive breast carcinoma on insulin glargine compared with other types of basal insulin

Satej N , Mori Lukancic M , Besic N

Background and aims: In vitro studies on breast cancer cell lines showed that the serum of diabetic patients was stronger mitogenic when using glargine as compared to other types of insulin. The aim of this retrospective study was to examine if the patients with diabetes mellitus (DM) using insulin glargine have a higher tumor stage of breast carcinoma in comparison to patients using other types of insulin.Patients and Methods: Altogether 174 pati...

ea0029p1584 | Thyroid (non-cancer) | ICEECE2012

Amiodarone- induced thyroid dysfunction in an iodine- deficient region

Ismailov S , Abdusalamova N , Kayumova N

Objective: To determine the incidence of thyroid dysfunction in a cohort of patients started on amiodarone therapy at a cardiac clinic in Tashkent, Uzbekistan, which is believed to be an iodine- deficient area.Methods: Pharmacy records were used to obtain the names of patients who received amiodarone between 2006 and 2009.Results: The original sample size was 96; 3 patients were excluded to incomplete data and data analysis was com...

ea0019oc35 | Thyroid, reproduction and endocrine tumours | SFEBES2009

Bio-informatic identification of novel endocrine markers of gestational disease in the human placenta

Karanam V , Anim-Nyame N , Page N

Searching for novel endocrine markers involved in gestational disease (e.g. pre-eclampsia, foetal growth restriction, pre-term labour) remains a challenge. Nonetheless, the placenta is a very useful target tissue as it provides a repository of gene expression transcripts that are uniquely expressed during pregnancy. Here, we have used bio-informatic approaches to identify expressed sequence tag (EST) clusters differentially expressed between 1st trimester and term placentae. T...

ea0003s33 | Parturition and Fetal Stress - Hormonal Strategies for Ensuring Life After Birth | BES2002

The prolactin receptor and pregnancy

Binart N , Baran N , Bachelot A , Kelly P

Prolactin (PRL) exerts pleiotropic physiological effects in various cells and tissues, and is mainly considered as a regulator of reproduction and cell growth. Null mutation of the PRL receptor (R) gene leads to female sterility due to a complete failure of embryo implantation. Pre-implantatory egg development, implantation and decidualization in the mouse appear to be dependent on ovarian rather than uterine PRLR expression, since progesterone replacement permits the rescue o...

ea0097025 | Section | BES2023

An extremely rare cause of psychosis, hypokalemia, and metabolic alkalosis

N. Mutebi , Leu N. De , D. Unuane

Cushing’s syndrome (CS) remains a diagnostic challenge due to an overlap with other clinical conditions such as pseudo-Cushing, which can be triggered by major depression, alcoholism, and metabolic syndrome. The most prevalent cause of CS is iatrogenic. When Cushing’s syndrome is caused by endogenous cortisol secretion, most often an ACTH-secreting pituitary adenoma is the culprit and the syndrome is hence referred to as Cushing’s disease. In very rare cases CS ...

ea0090js5.1 | Joint Session 5: ESE, SBEM, FASEN and SMNE | ECE2023

Obesity and metabolic syndrome in Type 1 Diabetes

Faradji Raquel N

In recent years there has been an increase in the incidence and prevalence of overweight and obesity around the world. Overweight and obesity are more common among people living with type 1 diabetes (T1D) than originally anticipated1 . The SEARCH study found 21% of T1D patients are overweight2 and 12.6%3 are obese. The T1D Exchange Study found an obesity rate of 13.1% in adolescents4 . The DCCT-EDIC Study found that the obesity preva...

ea0070s1.2 | New horizons in phaeochromocytoma and paraganglioma | ECE2020

Combination targeted therapies for malignant tumours – towards precision medicine

Nölting Svenja

For metastatic phaeochromocytomas (PCCs) and paragangliomas (PGLs), there are currently no highly effective therapies available. We therefore investigated multiple novel molecular-targeted drug combinations in murine PCC cell lines and, most importantly, in human PCC/PGL 2D and 3D primary cultures (n = 18). Additionally, we analysed signalling pathway alterations as well as somatic mutations in the patients’ tumours in order to correlate these data with drug responsi...

ea0029n16 | (1) | ICEECE2012

Planning for the future: preparing the endocrine specialist nurse of tomorrow

Carson Maggie N

We have come a long way in the UK over the past ten years towards our goal of meeting the educational needs of nurses specialising in adult endocrinology. Endocrine nurses are now able to access annual training updates and attend specific nurse-led sessions at scientific meetings thanks to the ongoing work undertaken by the Society for Endocrinology’s nurse committee.It is therefore time to turn our attention to how we can encourage nurses to want t...

ea0029p167 | Bone & Osteoporosis | ICEECE2012

Body composition in postmenopausal women with vertebral fractures

Povoroznyuk V. , Dzerovych N.

The aim of this study is evaluating body composition in postmenopausal women depending on presence of vertebral fractures in their anamnesis.Materials and methods: We’ve examined 144 postmenopausal women aged 50–83 years (mean age – 62.9±0.7 years; mean height – 160.6±0.5 cm; mean weight – 71.9±1.2 kg). The patients were divided into two groups: group A – women without vertebral fractures (n=82), group ...

ea0029p439 | Clinical case reports - Thyroid/Others | ICEECE2012

A case of papillary thyroid carcinoma with esophageal invasion treated by targeting PEI and transesophageal argon plasma coagulation

Nakano M. , Fukunari N.

There are several choices for treating esophageal cancer. But only operation is the standard therapy of papillary thyroid carcinoma with esophageal invasion. Esophageal stent and gastric fistula are chose when the patient can’t swallow because of esophageal stenosis by tumor invasion. But those put a lot of strain on the patient, and lower their quality of life. To reduce the burden on patient, it is useful to adopt targeting percutaneous ethanol injection (targeting PEI)...