Endocrine Abstracts

Introduction: De la Chapelle syndrome (46XX male syndrome) is a rare anomaly with the characterstics of discordant chromosomal and gonadal sex. Individuals with classical 46XX male sex reversal syndrome have an apparently normal male phenotype and presents with infertility or sub-fertility.Case report: Twenty five year old male, married 2 years back, came to take opinion regarding his Infertility. He is a healthy looking male with well developed secondar...

Objective: The objective of this study was to determine level of non-HDL and LDL cholesterol in type 2 diabetic patients with or without coronary artery disease irrespective on lipid lowering therapy and the common factors associated with elevated non-HDL cholesterol.Study design: cross-sectional study: Place and duration of study: diabetic clinic, Aga Khan University Hospital, Karachi. Data of Type 2 diabetes mellitus patients attended clinics during 20...

Purposes: To investigate the effects of α-lipoic acid (ALA) on diabetic dyslipidemia, endothelial dysfunction, levels of adiponectin and proinflammatory mediators in combination therapy of patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 40 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included history of IHD (7.2±2.3 years), T2DM (4.7&#177...

Purposes: To investigate effects of combination therapy with fenofibrate and α-lipoic acid (ALA) on atherogenic dyslipidemia, which determines the residual vascular risk and endothelial dysfunction, levels of proinflammatory mediators in patients with ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM).Methods: We examined 42 patients with IHD and T2DM (19 males, age 60.5±4.7 years). Baseline characteristics of patients included hi...

Recently, many cases with hypoglycemia who take oral hypoglycemic agents and/or insulin therapy are carried to the emergency room in our hospital due to hypoglycemia. Pharmacotherapy for patients with diabetes mellitus occasionally can causes severe hypoglycemic attack. In this study, we investigated 69 type 2 diabetics on clinical features (26 outpatients of our hospital, 43 outpatients of other clinics) among 100 patients who were carried to the emergency room due to hypogly...

Aim: The work was initiated to study depression manifestations in patients with primary hyperparathyroidism.Materials and methods: Symptoms of anxiety and depression were assessed in 67 patients with primary hyperthyroidism aged from 16 to 30 years examined by means of Spielberger–Khanin’s test and Beck’s Depression Inventory.Problem of marginal psychoneurotic disturbances in patients with various somatic pathologies...

It is generally accepted that hepatic responses to α-adrenergic agonists are dependent on the redistribution of intracellular and also extracellular Ca2+. Besides, phenylephrine induces significant K+ flux changes and plasma membrane hyperpolarisation. Earlier it was shown that K+ channel blockers as well as chelating of extracellular Ca2+ with EGTA could inhibit phenylephrine-induced metabolic responses and activation of mitoch...

A new genetic animal model of type 2 diabetes, the Tsumura Suzuki Obese Diabetes (TSOD) mouse, has been developed in 1999. The TSOD mouse develops a moderate degree of obesity and diabetes. The aim of this study was to investigate the potential association of impairment of lipolysis and lipid metabolism on the development of obesity and diabetes in TSOD mice.Methods: Three month old TSOD and the age-matched control (TSNO: Tsumura Suzuki Non-Obesity) male...

Background: Many endoscopic minimaly invasive procedures have been developed and are used now in thyroid and parathyroid surgery. However, the endoscopic approach is more technically demanding and due its limitations, endoscopic thyroidectomy remains limited in application and practiced in a relatively small number of centers. Recently robotic technology has been also applied to thyroid surgery. The aim of this study is to present our experience and to demonstrate the technica...

Introduction: Iodine deficiency is a common problem of public health that usually causes thyroid enlargement called goiter. It is estimated that 750 million people worldwide are at risk of Iodine Deficiency Disorders (IDD). IDD can be presented with a wide variety of clinical manifestations, which induce congenital anomalies, cretinism, deaf mutism, psychomotor defects and severe goiter.About 17 years after the initiation of salt iodization in Iran, this...