Searchable abstracts of presentations at key conferences in endocrinology

ea0012p91 | Pituitary | SFE2006

Metastatic lung carcinoma presenting as hypopituarism

Theron B , Iqbal N , Maksoud H , Duncan N

We present an unusual cause for symptomatic hypopituatism presenting due to a metastatic deposit. A 77 year old smoker and ex-miner was admitted with a 3 week history of breathlessness, malaise and weight loss. He had clinical evidence of a severe pneumonia but also had clubbing, was hypotensive, hypothermic and hypoglycaemic. He had no clinical features of Addison’s disease, no neurological symptoms or signs and a normal breast examination. Chest X-ray suggested extensiv...

ea0011p32 | Bone | ECE2006

Baseline characteristics of postmenopausal Greek women with osteoporosis who had inadequate clinical response to antiresorptive medications.

Ginis A , Charalampidou E , Thalassinos N , the Hellenic OSSO Study Group N

Aims: The Observational Study of Severe Osteoporosis (OSSO) is a 12-month, European, prospective study aiming to assess the changes in Health Related Quality of Life (HRQoL) of women with osteoporosis (OP) and an inadequate clinical response to antiresorptive (AR) medications.Methods: In Greece, 263 of 271 (97%) patients (pts) with severe OP met the inclusion criteria. The study population was assigned to1of 2 groups according to one or more of the follo...

ea0011p439 | Endocrine tumours and neoplasia | ECE2006

Hyperprolactinaemia in a series of adults with craniopharyngiomas and Rathke’s cleft cysts: what are the upper limits?

Thanabalasingham G , Karavitaki N , Meston N , Turner HE , Wass JAH

Introduction: Disruption of the hypothalamic dopaminergic inhibitory control of prolactin (PRL) secretion results in hyperprolactinaemia. We have previously shown in a large series of patients with non-functioning pituitary macroadenomas that serum PRL virtually never exceeds 2000 mU/l in the absence of PRL elevating medications. Current data on the effect of other sellar/parasellar masses are limited.Objective: To investigate the range of PRL values at ...

ea0010oc2 | Reproduction, neuroendocrinology and diabetes | SFE2005

Disruption of gap junctional communication within the ovarian follicle induces oocyte maturation

Abramovich S , Edry I , Galiani D , Nevo|N##Dekel N

Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This response is associated with interruption of gap junctional communication (GJC) within the ovarian follicle and can be reversed by elevation of intraoocyte cAMP. In the present study, we examined the hypothesis that termination of cellular communication in the ovarian follicle is sufficient for induction of oocyte maturation. To test our hypothesis we used rat follicle-enclosed oocytes (FEO) tha...

ea0010p1 | Bone | SFE2005

Vitamin D deficiency and renal-nonresponsive, bone-responsive pseudohypoparathyroidism (PHP-1b)

Chattopadhyay A , Al-Othman A , Bayoumy H , Moharib N , Nazmi N , #Q|A##

Pseudohypoparathyroidism-1b (PHP-1b) is a genetically and biochemically distinct disorder characterised by selective PTH resistance limited to the kidney and lack of Albright Hereditary Osteodystrophy (AHO). Due to calcium mobilization from bone, patients with PHP-1b may remain asymptomatic and undiagnosed for a long time. Coexistent vitamin D deficiency sometime unmasks the clinical presentation of the disease.A 15-year-old Kuwaiti male presented with s...

ea0008p63 | Neuroendocrinology and behaviour | SFE2004

Serum prolactin levels in patients with non-functioning pituitary adenomas and craniopharyngiomas

Shore HCA , Karavitaki N , Meston N , Turner HE , Wass JAH

Background: Pituitary stalk compression by sellar/parasellar tumours [commonly non-functioning pituitary adenomas (NFA) or craniopharyngiomas (CR)] is one of the causes of hyperprolactinaemia. However, in such cases the upper limits of serum prolactin (PRL) are not clearly defined ('grey zone': 3000-6000 mU/L) causing confusion in the differential diagnosis between disconnection hyperprolactinaemia and prolactin-secreting adenomas.Objective: To investiga...

ea0004p11 | Clinical case reports | SFE2002

Surgical Stimulation of a Silent Corticotroph to Secrete

Quinn N , Phillips N , Nelson M , Bridges L , Belchetz P

A 71 year old woman presented with visual loss. MR scanning demonstrated a massive invasive pituitary adenoma. She had no features of endocrine dysfunction. 0900hrs cortisol was 278nmol/L. Haemorrhage limited transphenoidal surgery to biopsies. Postoperative CSF leak was repaired 3months later. Histology revealed a corticotroph adenoma on immunostaining.At endocrine follow-up, afternoon cortisol was 645nmol/L, and 875nmol/L fasting, falling after glucago...

ea0002oc24 | Reproduction | SFE2001


Bell N , Graham G , Gibbins J , Lowry P , Page N

Mild symptoms of pre-eclampsia (PE) include hypertension and proteinuria, but more severe cases develop cerebrovascular accident, liver capsule distention, platelet pathology, pulmonary oedema and renal failure. As we have recently reported neurokinin B (NKB) levels to be significantly raised in the plasma of women with PE, the aim of this study is to establish the pathological role of NKB in this disease.NKB acts predominantly through the NK3 receptor, ...

ea0034p53 | Clinical practice/governance and case reports | SFEBES2014

Recurrent hypomagnesaemia, tackling modifiable risk factors

Alhelfi Moayed , Demssie Yared N

A 68-year-old lady presented to the medical assessment unit with history of muscle cramps involving both hands and legs of 5 days duration. She also gave a history of diarrhoea of 2 weeks duration. Her background medical history includes hypertension, hypercholesterolemia and dyspepsia for which she was taking Irbesartan/hydrochlorothiazide combination tablets, simvastatin and omeprazole.General physical examination revealed positive Chovstek’s and ...

ea0033p55 | (1) | BSPED2013

Diagnostic spectrum of female pubertal delay

Nanjundappa Suma , Alvi N Sabah

Introduction: Delayed onset of puberty is quite a common presentation in adolescent endocrine clinics, and the most common cause, particularly in boys is considered to be constitutional delay of growth and maturation. In girls, however, it is more likely that there is a significant underlying problem.Aim: To review the aetiology of pubertal delay in female patients referred to a single tertiary centre.Methodology: All female patien...