Endocrine Abstracts

Klinefelter syndrome (KS; 47,XXY) is the most common sex chromosome disorder in man, affecting approximately 1:660 men, and is a common cause of infertility.Patients with KS are characterized by tall stature and progressive testicular failure. This results in azoospermia and androgen deficiency with an accompanying risk of developing several phenotypic characteristics in adulthood, e.g., osteopenia or even frank osteoporosis, and metabolic syndrome.<...

The main concern of endocrinologist exploring an adrenal incidentaloma (AI) is the identification of malignant and/or secretant AI leading to rapid cure by removal of the tumor. PH remains one of the most difficult lesions to diagnose. In this study we analyze PH clinic, morphologic and secretory profile. Among a series of 91 AI recruited between 1987 and 2007 having benefited from an adrenal exploration, 56 have been removed and 18/56 were diagnosed as tumors of medullar orig...

Background: Recombinant human TSH (rhTSH) promotes 131I uptake in selected populations. Lithium increases RAI retention by reducing intra-thyroidal release. In this report, combination of rhTSH and lithium overcame low RAIU in Graves’ disease.Objective: We aim to present the case of a Graves’ disease given combination of rhTSH and lithium to overcome amiodarone-induced low 131I uptake.Methods and res...

Aims: To evaluate the process of patients from emergency room (ER) admittance until discharge from the endocrinology service (ES) with hypoglycemia or hyperglycemia.Methods: Two hundred twenty two patients either with hypoglycemia or hyperglycemia were evaluated. Hyperglycemic patients were divided into three groups: Patients with type 1 diabetes, type 2 diabetes and patients without diabetic history. The complaints, laboratory findings, stay in ER, stay...

Objective: Obesity and fat deposition in tissues along with inflammatory response may induce insulin resistance and finally type 2 diabetes mellitus Salsalate, a prodrug form of salicylate can inhibit IKKβ and NF-kappaB inflammatory pathway as a potential pharmacologic target in diabetes. The aim of this study was to determine the efficacy of salsalate as an anti-inflammatory drug to resolve endothelial dysfunction in diabetic patients.Methods: This...

With the development of medical imaging, many malignant lesions of the adrenal lodge are incidentally discovered. In this prospective monocentric study we are looking for factors of presumption of malignancy in the preoperative stage on a non-oncological series of 91 IS.Monocentric prospective study, AI revealed by TDM±echo supplemented by a clinic/hormonal adrenal exploration ±isotopic. In the absence of against indications, the indication of ...

Studies showed an increase of cardiovascular risk (CVR) and reduction of the life expectancy observed in the anterior pituitary insufficiency (API) subjects. The morbimortality would be related to GH deficiency not substituted.Aim: To seek the frequency of the hypertension and analyse the predictive factors in subjects with API.A retrospective study relating 55 (47 women, eight men) subjects with API: interrupted pituitarystalk n:6...

Older population and people with type II diabetes have a significantly higher rate of decline in cognitive function. However, the mechanisms are poorly understood. There are strong links between insulin and cognitive function supported by epidemiological data from humans and animal studies and in vitro research. Protein kinase C (PKC) signaling cascades and insulin pathways are closely integrated. The consequences of PKC activation by insulin in the CNS influence memory...

Objective: Estrogen receptors α and β are members of the nuclear receptor family which regulate target gene expression in response to estrogens and to growth factor receptors-mediated pathways. CXCR4 is a chemokine receptor whose physiological ligand is the stromal-derived-factor-1 (SDF-1), a chemokine with proliferative and chemotactic functions. Recently, we reported that ERβ activity can be modulated by the tyrosine kinase ErbB2/ErbB3 receptors and also by th...

Introduction: Surgical treatment of giant GH cell adenomas (>4 cm in maximum diameter; GHomas) has been considered difficult. However, clinical and histological characteristics of these adenomas are still enigmatic. We retrospectively analyzed data of 17 giant GHomas experienced at Toranomon hospital to clarify their characteristics.Methods: These 17 patients, accounting for 3.1% of 549 acromegalic patients undergoing surgery between 2006 and 2011, w...