Endocrine Abstracts

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. We aim to describe the epidemiological, clinical and paraclinical characteristics of PA and to analyse its therapeutic and evolutionary aspects.Patients and methods: Retrospective and descriptive study concerning 40 patients with PA, collect...

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. We aim to determine the different characteristics between aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH).Patients and methods: Retrospective descriptive and analytical study concerning 40 patients with PA, collec...

Introduction: Advances in diagnosis and treatment over the years have improved the life expectancy and quality of life for individuals with congenital adrenal hyperplasia (CAH). The inevitable alteration of the hypercortisolism-hyperandrogenism balance with current CAH therapy could be responsible for several anomalies in the gonadotropic axis and compromise fertility. This study aims to investigate this aspect in an aging Tunisian population of patients with CAH.<p class=...

Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. A prolonged exposure to high aldosterone concentrations has a deleterious effect on cardiovascular tissues and is associated with target organ damage, independently of blood pressure, so a higher risk of cardiovascular events has been reported in patients with pri...

Introduction: Primary aldosteronism (PA) is frequently recognized as the main cause of secondary hypertension. Its prevalence is on the rise, impacting a range of 1 to 30% among individuals with hypertension.Patients and methods: Retrospective and descriptive study concerning 40 patients with PA, collected in the endocrinology department of the Hedi Chaker University Hospital of Sfax, over the period of 10 years from January 2010 to December 2022.<p ...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder affecting adrenal steroid synthesis. Its treatment aims to achieve a balance between optimal glucocorticoid replacement and normal androgen levels. The long-term outcomes of this condition are poorly studied. The objective of this study is to evaluate the impact of CAH due to 21-hydroxylase deficiency on final height (FH), bone metabolism, and cardiometabolic risk in a Tunisian cohort.<p ...

Introduction: Congenital hyperinsulinism (CHI) is a rare disease with an incidence of 1 in 30,000. It is the most common cause of persistent neonatal hypoglycemia, primarily due to inhibitory mutations in genes encoding the ATP-sensitive potassium channel in pancreatic beta cells, with ABCC8 (SUR1) and KCNJ11 (Kir6.2) mutations being the most frequent. In this context, we report a highly unusual case in terms of phenotypic and evolutionary aspects.Clinic...

Introduction: Distal and symmetrical peripheral polyneuropathy is the most frequent type of diabetic neuropathy. Its painful form (PDN) is the most common cause of non-traumatic neuropathic pain and can place a heavy burden on elderly patients’ lives. Despite the major impact that it can have on the quality of life, PDN is generally underdiagnosed because of a large interindividual variability of symptoms and in the absence of well-established diagnostic criteria.<p c...

Introduction: Mitochondrial diabetes (MD) is characterized by a wide spectrum of phenotypic and genotypic manifestations. Through a cohort study of 40 patients with MD, we attempted to establish a correlation between this diversity of phenotypic expression and the biomolecular substrate of the mitochondrial genome within the Tunisian population.Results: Epidemiologically and anthropometrically, our series aligns with literature data, with an onset age of...

Introduction: Metabolic syndrome (MS) is responsible for the increased cardiovascular risk in type 2 diabetics. There is a scarcity of research on the metabolic syndrome among individuals diagnosed with type 1 diabetes (T1DM). The aim of this study is to describe clinical, biochemical and therapeutic characteristics of T1DM with MS.Materials and Methods: Retrospective study including 36 patients, with T1DM and MS, hospitalized in the department of Endocr...