Searchable abstracts of presentations at key conferences in endocrinology

ea0032p346 | Diabetes | ECE2013

Elevation of circulating free fatty acids abolishes down-regulation of skeletal muscle adiponectin receptor 1 (AdipoR1) expression caused by insulin infusion

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Stefanowicz Magdalena , Matulewicz Natalia , Kowalska Irina , Nikolajuk Agnieszka

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

ea0032p351 | Diabetes | ECE2013

Skeletal muscle and adipose tissue glycoprotein 130 expression is associated with insulin resistance in humans

Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Adamska Agnieszka , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

ea0032p735 | Obesity | ECE2013

Serum IL18 concentration is associated with resting energy expenditure independently of BMI

Nikolajuk Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

ea0022p859 | Thyroid | ECE2010

The influence of radioiodine therapy on some parameters of oxidant/antioxidant balance in patients with Graves’ disease

Abdelrazek Saeid , Rogowski Franciszek , Zonenberg Anna , Szelachowska Malgorzata , Gorska Maria , Frackiel Malgorzata , Nikolajuk Agnieszka , Szumowski Piotr

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...

ea0020p121 | Thyroid | ECE2009

The incidence of thyroid cancer in the North-Eastern Region of Poland: a twelve year follow-up

Zonenberg Anna , Telejko Beata , Nikolajuk Agnieszka , Siewko Katarzyna , Zimnoch Lech , Dadan Jacek , Kinalska Ida , Gorska Maria

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. It was also exposed to ionizing radiation after the Chernobyl accident in 1986. The aim of the present study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2007. The Regional Cancer Surveillance Program was used to collect data on 834 n...

ea0020p446 | Obesity and Metabolism | ECE2009

Serum visfatin concentration in obesity and impaired glucose tolerance – relationship with insulin resistance, blood pressure and proinflammatory factors

Kowalska Irina , Straczkowski Marek , Nikolajuk Agnieszka , Karczewska-Kupczewska Monika , Adamska Agnieszka , Gorska Maria

Visfatin, a protein secreted by the adipose tissue, might regulate insulin action. The aim of the present study was to assess serum visfatin concentration in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) and to estimate the relationships between serum visfatin concentration and insulin sensitivity, blood pressure, proinflammatory and proatherogenic factors.The study group consisted of 134 women: 30 overweight or obe...

ea0020p481 | Obesity and Metabolism | ECE2009

Relationships of TNFα system with glucose and lipid oxidation in subjects with different degree of insulin sensitivity

Adamska Agnieszka , Karczewska-Kupczewska Monika , Kowalska Irina , Nikolajuk Agnieszka , Gorska Maria , Straczkowski Marek

One of the key actions of insulin is the regulation of glucose and lipid oxidation. Disturbances in substrate oxidation play an important role in the development of insulin resistance. Insulin action is inversely associated with circulating pro-inflammatory cytokines such as soluble TNF-α receptors (sTNFR1 and sTNFR2).The aim of the present study was to analyze the associations between serum sTNFR1 and sTNFR2 concentrations and glucose and lipid oxi...

ea0020p500 | Obesity and Metabolism | ECE2009

Normal metabolic flexibility despite insulin resistance in lean and obese women with polycystic ovary syndrome

Straczkowski Marek , Kowalska Irina , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Lebkowska Agnieszka , Gorska Maria

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...

ea0014p73 | (1) | ECE2007

Circulating pro- and anti-inflammatory cytokines in women with gestational diabetes

Kuzmicki Mariusz , Telejko Beata , Zonenberg Anna , Szamatowicz Jacek , Kretowski Adam , Nikolajuk Agnieszka , Gorska Maria

Gestational diabetes mellitus (GDM) identifies a population of women at high risk of subsequent type 2 diabetes mellitus, representing an early stage in the natural history of the disease. Systemic inflammation is associated with the development of type 2 diabetes but the data concerning pro- and anti-inflammatory cytokines in patients with GDM are limited. The aim of our study was to investigate serum concentrations of interleukin-8 (IL-8), IL-18 and IL-10 in pregnant women w...

ea0014p233 | (1) | ECE2007

Serum interleukin 6 and soluble form of interleukin 6 receptor concentrations in obese subjects with impaired glucose tolerance

Nikolajuk Agnieszka , Straczkowski Marek , Kowalska Irina , Adamska Agnieszka , Kinalska Ida , Gorska Maria

Background: Obesity is associated with an increased risk of impaired glucose tolerance and type 2 diabetes. Insulin resistance is the link between obesity and disturbances of glucose metabolism. It is suggested that some substances secreted by adipose tissue might play a role in the pathogenesis of insulin resistance. One of these substances is interleukin-6 (IL-6), cytokine, which regulates synthesis of the acute-phase proteins in the liver. The aim of the present study was t...