Endocrine Abstracts

Nowadays the human insulines and insuline analogues are used in the treatment of diabetes.The Advantages of modern insulinesBetter glycemic control;Reduction of hypoglycemiaThe reduction of the weight;Low variability of developing of the complication.The objective of the survey is to come up to the specific functional benefits about modern i...

Aromatase is the only enzyme converting androgens into estrogens, which are key actors in reproductive biology. Teleost fishes have two copies of the cyp19a1 gene, which encode two isoforms of aromatase: cyp19a1a encodes ovarian aromatase, while the cyp19a1b gene encodes brain aromatase. Our recent work showed that, in zebrafish, aromatase B is strongly expressed in a unique brain cell type, the radial glial cells (RGC). In mammals, such cells act as stem cells during embryoni...

Autoimmune polyendocrine syndrome type I (APS-1) is a rare autosomal recessive disorder which starts in early childhood, typically associated with chronic mucocutaneous Candidiasis. Patients with APS-1 later develop autoimmunity against endocrine tissues such as the adrenal cortex and the ovaries, and non-endocrine tissues such as the liver and melanocytes. The disease is caused by mutations in the autoimmune regulator (AIRE) gene that encodes a 54 kDa protein expressed in thy...

Introduction: Insulin induced Prolonged QTc interval cause severe ventricular arrhythmias and sudden cardiac death.The purpose of this study is to reveal the effects of metoprolol,diltiazem and pilocarpine on insulin induced prolonged QTc interval(Bazett)Material-Method: In this study 24 Sprague-Dawley adult male rats were used.Before application under anesthesia ECG were taken in derivation(D)I and normal QTc interval was determin...

Background: Standards of penile and clitoral lengths are useful for diagnosis of genital abnormalities. Micropenis could be the only sign in pituitary/hypothalamic dysfunction while clitoromegaly may reflect abnormalities of neonatal and maternal origin. Ambiguous genitalia if missed at birth could be fatal especially in cases of congenital adrenal hyperplasia. There are no African reports on normal reference ranges of both penile and clitoral sizes. This study aimed to genera...

For realisation of Sent-Vinsent declaration we organised the group of diabetic pregnant women for observation. 32 patients were examined. Besides common clinical and biochemical examination we conducted measurement of plasma circulation immune complexes (CIC) levels. The control group comprised 10 normal pregnant women. Normal pregnant state: CIC level was 169,64 ±2,93 u.o.s.In diabetic pregnant state with decompensation stage CIC level was 450,7...

Introduction: The prevalence of diabetes mellitus among Nigerian adults has been increasing over time. A considerable number of chronic complications of DM can be adequately prevented, however, the proportion of patients presenting with chronic complications of DM in our setting is still relatively high.Objectives: This study was carried out to assess the pattern of chronic diabetic complications among patients attending the diabetic clinic of Lagos Univ...

Aim: The aim of the study was to determine the association between Hashimoto’s thyroiditis (HT) and differentiated thyroid carcinoma (DTC).Patients and methods: Seven hundred seventy two patients with thyroid nodular goiter who underwent fine-needle aspiration cytology (FNAC), followed up at Endocrinology and Metabolism out-patient clinic of Cerrahpasa Medical School, University of Istanbul between January 2000 and December 2010 were included retros...

Introduction: Infertility affects 15% of couples and a male factor accounts for 50% of cases. Adequate history taking, examination of both partners, hormone testing and semen analysis are required to ascertain a cause and treatment strategy. Gonadotropin therapy with Human Chorionic Gonadotropin (HCG) and recombinant Follicle Stimulating Hormone (rFSH) is indicated for use in men with reduced spermatogenesis due to hypogonadotropic hypogonadism (HH). We pres...

Introduction: Infertility affects 15% of couples and a male factor accounts for 50% of cases. Adequate history taking, examination of both partners, hormone testing and semen analysis are required to ascertain a cause and treatment strategy. Gonadotropin therapy with Human Chorionic Gonadotropin (HCG) and recombinant Follicle Stimulating Hormone (rFSH) is indicated for use in men with reduced spermatogenesis due to hypogonadotropic hypogonadism (HH). We pres...