Endocrine Abstracts

Introduction: Type 1 diabetes can be associated with one or more other autoimmune pathologies in case of predisposing immune background.The aim of our study was to research the autoimmune pathologies associated with type 1 diabetes and to describe the clinical and biological characteristics of this population.Patients and Methods: This is a retrospective descriptive study including 26 patients with type 1 diabetes with at least one...

Background: Polycystic ovary syndrome (PCOS) is clinically associated with increased risk of CVD. Thrombin generation (TG) is a measure of the thrombotic potential. This can be expressed as endogenous thrombin potential (ETP) representing the total amount of generated active thrombin over the time (nmol/l×min). ETP is considered the most predictive parameter of thrombosis and is associated to both venous and arterial thrombotic disease. Setting: PCOS women prospectively r...

We reported the isolation and structural characterization of CPF-AM1 and other peptides from the skin secretion of Xenopus amieti. This study investigated the insulin-releasing activities of synthetic CPF-AM1 using clonal pancreatic cell line, BRIN-BD11 and Swiss TO mice with diet-induced insulin resistance.Acute insulin-release studies were performed in Krebs Ringer bicarbonate buffer supplemented with 5.6 mM or 16.7 mM glucose, purified synthetic pepti...

Exogenous corticotropin-releasing factor (CRF) induces an increase in glucocorticoid production and also may protect the gastric mucosa against stress-induced injury. However, it remained unknown whether glucocorticoids released in response to CRF injection contribute to the gastroprotective effect of CRF. In the present study we investigated whether exogenous CRF may protect the gastric mucosa against gastric injury through involvement of glucocorticoids and, consequently, th...

Introduction: There is no published data on dispensed drug pattern in patients with Autoimmune Addison’s disease (AAD). Sweden has excellent condition for research in this area, with high-quality population based registers. Among them is the Swedish Prescribed Drug Register (SPDR) that contains information about dispensed prescribed drugs. By linking registry data, we aimed at accurately estimate the prevalence and incidence of AAD, the prevalence of common concomitant au...

Recent findings suggested two-way interaction between bone and adipose tissue. Osteocalcin, a hormone of osteoblasts, was shown to stimulate insulin sensitivity by direct interaction with insulin. Adipose tissue has an important effect on insulin sensitivity by secretion of anti-inflammatory and proinflammatory adipocytokines like adiponectin and monocyte chemoattractant protein-1 (MCP-1). It is unknown whether they are related to bone metabolism.Aim of ...

Introduction: Here, we present a case of epithelial breast cancer releasing iPTH thereby causing MAH.Case report: A 48-year-old woman with metastatic breast cancer was consulted for hypercalcemia. Previous medical record was insignificant except for nephrolitiasis. She had a left mastectomy+left axillary lymph node dissection in another hospital. Prior to surgery no calcium levels were obtained. Pathology revealed infiltrative ductal carcinoma. Postopera...

Myeloperoxidase (MPO), an enzyme of the innate immune system, exhibits pro-atherogenic effects and includes influence on oxidative damage to LDL- and HDL-cholesterol, and promotion of endothelial dysfunction.The aim: To investigate the disturbance of MPO in type 2 diabetic (T2D) patients depending on intensity of atherosclerosisMaterial and methods: We investigated 244 patients aged from 45 to 60 years (M±SD 54.0±4.63) in...

Introduction: The increased mortality in acromegaly is mainly related to cardiovascular, respiratory and neoplastic complications; neoplasms being responsible in 15%. Although most of the thyroid nodules in acromegaly are benign, there are studies revealing an increased ratio of differentiated thyroid cancer in this disease. Medullary thyroid carcinoma (MTC) has not been related with acromegaly so far. In this report, we aimed to present a patient with acromegaly whose thyroid...

5-Alpha reductase deficiency is a rare 46, XY disorder of sex differentation caused by mutations in the 5-alpha reductase type 2 gene (SRD5A2) located on chromosome 2p23. Affected patients have a deficiency of the 5-alpha reductase type 2 enzyme, which becomes partially or totally unable to convert testosterone into dihydrotestosterone, the latter being responsible for the development of the external genitalia, prostate, and urethra in the male fetus. Most affected individuals...