Searchable abstracts of presentations at key conferences in endocrinology

ea0029p589 | Diabetes | ICEECE2012

Microcirculatory disorders in adolescents with type 1 diabetes mellitus

Nikolaeva N , Bolotova N , Filina N , Kompaniets O

Aim: To study microcirculatory disorders in adolescents with type 1 diabetes mellitus (T1DM).Patients and methods: Eighty-five adolescents 12–17 years with T1DM were examined. The duration of T1DM was: <1 year – in 29 (HbAc1 7.1±0.4%) – group 1, from 1 to 5 years – in 26 (HbAc1 9.2±1.1%) – group 2, more then 5 years – in 30 patients (HbAc1 10.7±1.1%) – group 3. The indexes of tromboresistance of vesse...

ea0029p913 | Female Reproduction | ICEECE2012

The kisspeptin levels in girls

Gumenyuk O. , Chernenkov Y. , Zakharova N. , Kunina A. , Kunina S.

The kisspeptin, the peptide product of KiSS-1 gene has recently emerged as essential gatekeeper of pubertal activation of gonadotropin-releasing hormone neurons and the reproductive axis. Mutations or targeted disruptions in the gene cause hypogonadism or premature sexual development and sterility.Purpose: The study was undertaken to research the kisspeptin levels in healthy girls and girls with endocrine and gynaecological disorders.<p class=...

ea0029p1086 | Neuroendocrinology | ICEECE2012

Relationship between sex hormones, cognitive performance and substance use

Zilbermint M , Xu X. , Wisniewski A. , Selnes O. , Dobs A.

Hypogonadism is prevalent with opiate-like drug use and might be a factor in cognitive abnormalities. With the increasing substance use (SU) worldwide, it is critical to recognize its impact on cognition, which may decrease adherence to treatment and alter quality of life. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or drug use, may demonstrate impaired cognitive function.We recruited men aged 18–50 from a low-in...

ea0029p1256 | Obesity | ICEECE2012

The oxidative stress parameters within the context of metabolic syndrome evolution in men

Tsygankova O. , Platonov D. , Bondareva Z. , Latyntseva L.

Introduction: The aim of study was to assess diversity of oxidative stress as a dynamic process throughout metabolic syndrome (MS) continuum ending with coronary heart disease (CHD) or diabetes mellitus (DM).Methods: Main group (MG) of 154 men aged 25–60 years with abdominal obesity (waist circumference above 94 cm) was examined in comparison to 30 healthy men of similar age. In MG 28 men were diagnosed with CHD, 24 – with DM. Fasting glucose (...

ea0029p1340 | Pituitary Basic | ICEECE2012

mTOR inhibitor Torin1 induces antiproliferative effects in MtT/E cell line and human pituitary tumors

Rubinfeld H. , Cohen O. , Fratty I. , Hadani M. , Shimon I.

As for many tumor types, it has been shown that the Akt pathway is overexpressed and activated in human pituitary tumors. Thus, pituitary tumors may be sensitive to the anti-proliferative effects of mTOR inhibitors. However, part of non-functioning pituitary tumors are rapamycin-resistant. Torin1, second-generation ATP-competitive mTOR kinase inhibitor, suppresses both mTORC1 and mTORC2 complexes. To evaluate the in vitro effects of the mTOR inhibitor Torin1 on pituitar...

ea0029p1526 | Pituitary Clinical | ICEECE2012

Growth hormone effects on lipid profile in patients with acromegaly

Mykytuyk M. , Khyzhnyak O. , Sulima T. , Karachentsev Y.

Introduction: Active acromegaly is associated with increased mortality, which has been attributed largely to cardiovascular disease.Aims: To evaluate the effects of chronic excess of GH and IGF1 on lipid metabolism in patients with active acromegaly.Subjects and methods: Ninety-seven patients (37 men and 60 women; aged 18–76 years) with macroadenoma of hypophysis (67 – somatotropinoma, 30 – somatomammotropinoma) were...

ea0029p1571 | Thyroid (non-cancer) | ICEECE2012

An audit and patient satisfaction survey of the telephone endocrine clinic at University Hospital Lewisham, London

Mustafa O. , Gan J. , Evans K. , Mohandas C. , Miell J.

Introduction: The telephone endocrine clinic (TEC) was established as an adjunct to the face-to-face endocrine clinic to follow and monitor the progress in a selected group of patients after they were seen in main endocrine clinics. This model of care has been tried successfully in other specialities but not as widespread in endocrinology. We audited the effectiveness of TEC and patient satisfaction. Methods: A retrospective analysis of records of all patients contacted in TEC...

ea0029p1678 | Thyroid (non-cancer) | ICEECE2012

Optimal timing of thyroxine dose adjustment for treating patients with primary hypothyroidism: what is the estimated time required to reach stable TSH levels?

Kohler S. , Senn O. , Saleh L. , Wass J. , Schmid C.

Aim: Serum TSH is the target value by which adequate thyroid hormone supply can easily be monitored in patients with primary hypothyroidism. It is controversial when TSH should be measured before thyroxine dose adjustments are made, 4–8 weeks are recommended. To define the time when dose adjustments of thyroxine are feasible more clearly, we looked at the time required to reach stable TSH levels.Methods: We prospectively studied a case series of pat...

ea0029p1854 | Thyroid cancer | ICEECE2012

Diffuse Large B Cell Lymphoma of Thyroid Gland Presenting With Acute Tracheal Compression

Incecayir O. , Anaforoglu I. , Kocak G. , Karyagar S. , Algun E.

Introduction: Non-Hodgkin lymphoma (NHL) involving the thyroid gland constitutues 2–3% of all NHL cases, 2–8% of all thyroid malignancies. The majority of lymphomas arising in the thyroid gland are MALT lymphomas and diffuse large B cell lymphomas commonly occuring in the setting of thyroiditis. Most cases are seen in adult or elderly females. The thyroid enlargement is often rapid and can lead to symptoms of tracheal or laryngeal compression. Herein, we present a ca...

ea0026p3 | Adrenal cortex | ECE2011

MicroRNAs as endogenous modulators of glucocorticoid receptor expression in the adrenal gland after ACTH stimulation test

Hill A , Issler O , Spyroglou A , Haramati S , Chen A , Beuschlein F

MicroRNAs (miRs) are a subset of small RNA molecules that regulate gene expression post-transcriptionally. Little is known about the expression and the role of miRs in the adrenal gland. Thus, we determined the miRs expression pattern under baseline conditions and 10, 30 and 60 min after ACTH stimulation test in mice adrenal glands using miRs microarray. The miRs expression profile of adrenals obtained from the array was bioinformatically analyzed to indentify miRs that putati...