Endocrine Abstracts

A 24-year old male who, was normal at birth, became listless and volume depleted at 3 weeks of age. Investigations yielded an Addisonian picture (serum Na+ 115 mmol/l; K+ 8.2 mmol/l; urea 15.8 mmol/l). Serum 17-hydroxyprogesterone (17-OHP) levels were measured and found to be high (2,564 nmol/l). Urinary 17-oxosteroids and 17-OHP were also elevated. The neonate was thought to have 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and therapy with fludrocortisone an...

A thirty year old woman with complete 21-hydroxylase deficiency presented with a five centimetre adrenal mass necessitating operative removal to exclude malignant change. Her medical management had always been unsatisfactory, and she had been tried on both hydrocortisone and dexamethasone. When taking 1 milligram dexamethasone daily she had partially suppressed androgen levels, (evidenced by a fall in 17-hydroxy-progesterone levels to 29 nmol/l), at the expense of marked Cushi...

The index case, a 26-year-old man, presented with a 15-month history of gynaecomastia. Investigations revealed a large left-sided adrenal mass that secreted oestrone and oestradiol, with suppression of FSH, LH and testosterone production. It was removed in 1991 with correction of the hormonal abnormalities and follow-up has shown no recurrence to date.In April 2001 the eighteen-month old daughter of the index case developed greasy skin, acne, pubic hair...

Insulin like growth factor-1 (IGF-1) has been shown to co-vary with renal function in a number of physiological and pathological conditions. However, this relationship and possible co-variants have not been specifically explored in untreated growth hormone deficient adults (GHDA). To examine this issue, we studied 24 GHDA subjects (14M, 10F) in the fasted state twice after obtaining consent and ethical approval. The Cockcroft and Gault equation was used to calculate creatinine...

IntroductionSubacute thyroiditis is a rare cause of thyrotoxicosis arising in the context or following viral infections. This disorder is more frequent in women than in men (male/female ratio of 1:4). In addition to respiratory symptoms, the SARS-CoV-2 infection (COVID-19) has been associated with extrapulmonary manifestations. Herein we report a male patient with hyperthyroid symptoms starting four-week after a positive test for COVID-19.<p class="a...

Introduction: Radioactive iodine (RAI) has been used to treat hyperthyroidism for over 70 years. Some centres use a fixed dose regimen while others use a calculated dose regimen. Cure rates range between 80% and 100%, with some patients requiring two or more doses. We use the fixed-dose regimen at our centre. We therefore evaluated our cure rates after a single dose of RAI to treat hyperthyroidism.Methods: We reviewed th...

Cycline D1 gene that plays a crucial role in a cell cycle, have been shown to be expressed more in nonfunctioning pituitary adenomas and functioning invasive pituitary adenomas compared to normal hypophisis tissue and noninvasive pituitary adenomas. A/G polymorphism in CyD1 gene exon 4/intron 4 regions have been demonstrated to affect clinical outcomes and survey in some tumors. Objective of this study was to investigate the effect of polymorphism of cycline D1 gene on the tum...

Introduction: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and related disorders. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflammation. But there are controversial data whether increased the uric acid level in PCOS patients. This study was aimed to examine the relationship between uric acid, lipoprotein l...

In prolactin secreting pituitary adenomas, surgery markedly reduced with the efficacy of dopamine agonists in controlling prolactin hypersecretion and reducing tumor mass. Some surgeons, instead of necessity of almost life-long medical therapy, prefer and recommend surgery as a first line treatment with potentially high success rates especially in microprolactinomas. We evaluated our patients with prolactinoma operated mostly without any evidence of resistance or intolerance t...

Context: Decreased levels of both vitamin D and insulin-like growth factor 1 (IGF1) may be associated with obesity, however this had not been well established. We have examined the relationship of vitamin D status and circulating IGF1 with metabolic parameters in abdominal obesity women.Methods: Serum 25(OH)D and IGF1 levels were measured by means of ELISA in 90 women (mean age 45.6±4.3) with abdominal obesity (according to IDF criteria, 2005). Anth...