Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder characterized by androgen excess, ovulatory dysfunction and polycystic ovaries. The phenotypic presentation might differ between referral and unselected populations and varies within an individual over time and between individuals of different ethnic and geographic regions. Women with PCOS have increased prevalence of prediabetes and diabetes and have multiple risk factors for cardiometa...

Insulin resistance and androgen excess, alongside anovulatory infertility, are the cardinal clinical and biochemical features of polycystic ovary syndrome (PCOS). Circulating androgen burden and metabolic dysfunction in PCOS are closely correlated, but an independent contribution of androgens per se to metabolic and other complications of PCOS remains poorly characterised. My work since 2012 has focused on delineating the distinct impact of androgens on metab...

Disorders of bone tissue as a complication of hyperthyroidism now become accepted fact. On other side decreasing of serum levels of estrogens in postmenopausal women potentially may increase effects of thyroid hormones on bone tissue.The aim of our study was investigate with DXA the features of loss of bone mass in women suffering from thyrotoxicosis depending of age and thyrotoxicosis duration.Material and methods: There were exam...

The pathophysiology of type 2 DM is complex and involves insulin resistance, pancreatic beta cell dysfunction and visceral adiposity. The levels of free fatty acids (FFA) increases in obese persons and diabetic patients. Elevated levels of FFAs may cause resistance and deficient insulin secretion. Our aim in this study was to investigate the change of FFA levels, glucose, insulin and triglyceride in fasting and postprandial state in 15 healthy controls and 45 diabetic patients...

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism between the age 50–65 years (55.00 (50.00; 58.00)) were treated with a 1% testosterone gel within 12 months.Results: Testosterone levels increased from 4.65 (2.70; 6.10) nmol/l at baseline to 13.65 (12.60; 15.20) nmol/l after 48 weeks of treatment (...

Aim: Evaluate anamnesis, clinical and laboratory parameters in children with autoimmune thyroiditis (AT).Methods: We analyzed retrospectively 211 children in the endocrinological department of University hospital (Minsk) over 2002–2011 years. The number of boys (B) 42 (19.9%), of girls (G) -169 (80.1%) (stage on Tanner1- 15 (35.7%) B, 58 (24.3%) G; stage2-3 – 19 (70.3%) B, 65 (58.6%) G; stage 4-5 – 8 (29.7%) B, 46 (41.4%) G). Ultrasound of...

Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves’ ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor-β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO.Methods: The following ...

Objective: To present an unusual case of a goitre co-existing with bilateral thryoglossal fistula.Introduction: AF, a 32-year-old male presented with 4 years history of an anterior neck swelling associated with palpitations, heat intolerance, protrusion of the eyeballs, weight loss, tremors of the hands and generalized weakness.Prior to onset of the neck swelling, he had noticed since childhood that whenever he drinks any fluid, so...

Obesity and type 2 diabetes are common and complex traits that are closely related and the term ‘diabesity’ is being used for the twin global epidemic of these two disorders. PCOS is another common and complex disorder characterized by androgen excess, oligo-anovulation and polycystic ovaries on ultrasound. PCOS is linked with both obesity and type 2 diabetes. Although obesity and type 2 diabetes are not universally observed in PCOS, many women with PCOS are obese an...

M O Thorner, University of Virginia, Charlottesville, VA, USA AbstractMichael O. Thorner is David C. Harrison Teaching Professor of Internal Medicine. He previously was Kenneth R. Cripsell Professor, Chief of the Division of Endocrinology and Director of the General Clinical Research Center and Henry B Mulholland Professor and Chair, Department of Internal Medicine at the University of Virginia. He is a fellow of the A...