Searchable abstracts of presentations at key conferences in endocrinology

ea0035p624 | Female reproduction | ECE2014

Prevalence of metabolic syndrome in obese women with polycystic ovary syndrome

Antic Ivana Bozic , Macut Djuro , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Petakov Milan , Popovic Bojana , Ilic Dusan , Bogavac Tamara , Ognjanovic Sanja , Isailovic Tatjana , Elezovic Valentina , Damjanovic Svetozar

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy women. However, it is still unclear weather this is a consequence of PCOS per se or higher prevalence of obesity in this population. The aim of this study was to determine prevalence of MS in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We e...

ea0070aep40 | Adrenal and Cardiovascular Endocrinology | ECE2020

Association of the subclinical hypercorticism and BclI glucocorticoid receptor polymorphism with bone mineral density in women with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Antic Jadranka , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Bozic Antic Ivana , Ilic Dusan , Elezovic Kovacevic Valentina , Damjanovic Svetozar

Most of adrenal incidentalomas (AI) are nonfunctional, although some of those demonstrate an autonomous subtle cortisol hypersecretion that could lead to increased risk for osteoporosis. Several polymorphisms of glucocorticoid receptor (GR) gene have been found to alter glucocorticoid tissue sensitivity. The aim of this study was toinvestigate whether subclinical hypercortisolism (SH) and BclI variant of the GR gene have an impact on bone mineral density (BMD) in wome...

ea0070aep87 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cortisol response to acute stress is dependent on previous stress exposure and sex of the examined humans

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Isailovic Tatjana , Bozic Antic Ivana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Prolonged exposure to stress has a modifying effect on activity of hypothalamo-pituitary-adrenal (HPA) axis. This is a protective adaptation aimed to diminish potential deleterious effects of chronic hypercortisolism, and to diminish effects of acute exposure to heterotypic forms of stress. Our aim was to analyze modes of cortisol response to acute physical stress in groups of different stress categories and sex.Subjects and methods: Study ...

ea0032p274 | Clinical case reports - Thyroid / Others | ECE2013

Paraganglioma, germline nonsense mutation in succinate dehydrogenase B gene (R27X) and response to sunitinib

Elezovic Valentina , Petakov Milan , Ognjanovic Sanja , Macut Djuro , Isailovic Tatjana , Ilic Bojana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

A 36-years-old male with mild hypertension was diagnosed with pseudocystic tumor (67 mm) in pancreatic region and liver metastasis in April 2010. One month later, the extirpation of retroperitoneal mass and metastasis was performed in local medical centre. Pathohistological diagnosis was metastatic paraganglioma (Ki67, 3.5%). In June 2010, he was transferred to our Institution, and (131) I-metaiodobenzylguanidine (MIBG) scintigraphy was negative. However ((18) F) fluorodeoxygl...

ea0032p531 | Endocrine tumours and neoplasia | ECE2013

Long-term outcome after transarterial chemoembolization of hepatic metastases from neuroendocrine tumors

Ognjanovic Sanja , Petakov Milan , Isailovic Tatjana , Elezovic Valentina , Macut Djuro , Popovic Bojana , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Colic Momcilo , Damjanovic Svetozar

Introduction: Most patients with neuroendocrine tumors (NETs) present with liver involvement at the time of diagnosis. Trans-catheter arterial chemoembolization (TACE) is accepted treatment of patients with non-resectable hepatic metastases from NETs.Aim: To analyze objective tumor response and clinical outcome in patients with hepatic metastases from NETs who underwent TACE.Methods: Thirty-one patients underwent 140 TACE procedure...

ea0032p535 | Endocrine tumours and neoplasia | ECE2013

Adrenal lesions in patients with neuroendocrine tumors

Popovic Bojana , Macut Djuro , Petakov Milan , Bozic Ivana , Bogavac Tamara , Isailovic Tatjana , Ognjanovic Sanja , Elezovic Valentina , Micev Marjan , Menkovic Nemanja , Ilic Dusan , Damjanovic Svetozar

Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed accordin...

ea0032p587 | Female reproduction | ECE2013

The hypothalamo--pituitary--adrenal axis sensitivity in women with polycystic ovary syndrome

Ilic Dusan , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Milutinovic Danijela Vojnovic , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Damjanovic Svetozar

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

ea0032p602 | Female reproduction | ECE2013

Relation of adiponectin and leptin to antropometric and metabolic parameteres in women with polycystic ovaries syndrome

Bogavac Tamara , Macut Djuro , Bozic Antic Ivana , Bjekic-Macut Jelica , Vojnovic Milutinovic Danijela , Petakov Milan , Popovic Bojana , Ognjanovic Sanja , Isailovic Tatjana , Elezovic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

ea0032p893 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Myeloproliferative neoplasms in patients with acromegaly

Isailovic Tatjana , Beleslin Bojana , Lalic Nebojsa , Lukic Ljiljana , Popovic Bojana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Pekmezovic Tatjana , Damjanovic Svetozar

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

ea0014oc4.6 | Neuroendocriology basis | ECE2007

Metabolic abnormalities in patients with adrenal adenomas may be associated with BclI polymorphism in the glucocorticoid receptor (GR) gene and expression of tumor-specific hsp70 isoforms

Damjanovic Svetozar , Antic Jadranka , Beleslin Bojana , Ognjanovic Sanja , Vignjevic Jovana , Petakov Milan , Macut Djuro , Paunovic Ivan , Isailovic Tatjana , Popovic Bojana , Bozic Ivana

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...