Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp197 | Thyroid - Basic | ECE2016

Evaluation of interrelations between resistin, adiponectin, PAI-1, intercellular adhesion molecule and thyroid function in autoimmune thyroid disease

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Esteves Cesar , Sokhatsha Oksana , Delgado Luis , Medina Jose Luis , Carvalho Davide

Introduction: Given the significant impact of thyroid function on body weight, energy metabolism and adipocytes physiology, our aim was to study the impact of subclinical thyroid dysfunction in plasmatic levels of adipokines and ICAM-1 (intercellular adhesion molecule 1).Methods: We evaluated 98 patients with autoimmune thyroid disease divided into three groups: 30 who were euthyroid (TSH=0.35–4.94 UI/ml), 35 with subclinical hypothyroidism (hypoSC,...

ea0041ep950 | Pituitary - Clinical | ECE2016

Ketoconazole in Cushing’s disease management

Oliveira Sofia , Neves Joao , Neves Celestino , Belo Sandra , Freitas Paula , Pignatelli Duarte , Castedo Jose , Vinha Eduardo , Oliveira Ana , Carvalho Davide

Background: Transphenoidal surgery is still the best initial therapy for Cushing’s disease (CD), with a high probability of cure and few risks or complications. However, pharmacotherapy has a role as primary or adjunctive therapy: when surgery is delayed, in case of postoperative persistence or recurrence of hypercortisolism, or while waiting for radiotherapy effectiveness. Ketoconazole, a steroidogenesis inhibitor, is nowadays the main drug used to CD control by reducing...

ea0037ep1296 | Clinical Cases–Thyroid/Other | ECE2015

Radioguided excision of occult metastatic lesion in thyroid carcinoma: a safe technique for previously operated neck in two patients

Martins Teresa , Azevedo Teresa , Santos Jacinta , Rodrigues Fernando , Rovira Eugenia , Oliveira Sofia , Neto Joao , Neves Antonio , Gilde Patricia , Cruz Carlos

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...

ea0056p510 | Diabetes therapy | ECE2018

Psychopathological determinants of enhanced quality of life in continuous subcutaneous insulin infusion therapy

Pereira Miguel , Goncalves Ana , Neves Celestino , Oliveira Sofia , Esteves Cesar , Arteiro Cristina , Costa Anabela , Redondo Carmo , Carvalho Davide

Introduction: Scientific progress allowed an evolution on the therapeutic of diabetes mellitus. Continuous subcutaneous insulin infusion therapy (CSII) is one good example, but, beside patients motivation little is known about other psychological factors of success in this therapeutic and how they contribute to quality of life (QoL).Objectives: Determining some psychopathological predictors of CSII satisfaction and QoL improvement in patients on CSII the...

ea0073aep742 | Thyroid | ECE2021

Anomalous uptake of 131-iodine in an endometriosis cyst

Rita Elvas Ana , Marques Bernardo , Couto Joana , Raquel G. Martins , Santos Jacinta , Martins Teresa , Oliveira Sofia , Rodrigues Fernando

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

ea0063gp76 | Thyroid Autoimmune Disorders | ECE2019

Cardiovascular risk factors, autoimmunity and insulin resistance in Graves disease

Ferreira Catia Tomas , Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

ea0063gp77 | Thyroid Autoimmune Disorders | ECE2019

Lipid profile, insulin resistance and cytokines evaluation in autoimmune thyroiditis patients

Goncalves Juliana , Neves Celestino , Pego Francisco , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

ea0063gp78 | Thyroid Autoimmune Disorders | ECE2019

Autoimmune thyroiditis, Graves’ disease and adiponectin, resistin and plasminogen activator inhibitor-1 levels

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Sokhatska Oksana , Pereira Miguel , Oliveira Ana , Medina Jose Luis , Delgado Luis , Carvalho Davide

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...

ea0049gp199 | Thyroid 1 | ECE2017

Cardiovascular risk factors in patients with autoimmune thyroiditis

Neves Joao Sergio , Cunha Catarina , Neves Celestino , Oliveira Sofia Castro , Sokhatska Oksana , Dias Camila , Esteves Cesar , Pereira Miguel , Medina Jose Luis , Delgado Luis , Carvalho Davide

Background: Overt thyroid dysfunction is associated with an increased cardiovascular risk. The impact of subclinical hypothyroidism and autoimmunity in the increased cardiovascular risk remains controversial. Aim: To evaluate the interrelations between thyroid function, thyroid autoimmunity and cardiovascular risk factors, in patients with autoimmune thyroiditis (AIT).Methods: 353 subjects with AIT were evaluated. We defined three groups based on TSH lev...

ea0049ep53 | Adrenal cortex (to include Cushing's) | ECE2017

Adrenal cushing’s syndrome surprisingly unveiling breast cancer

Neves Joao Sergio , Oliveira Ana Isabel , Souteiro Pedro , Oliveira Sofia Castro , Baldaia Helena , Melo Daniel , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Cushing’s syndrome is an endocrinopathy characterized by glucocorticoids excess. Adrenalectomy is the recommend treatment for unilateral adrenal Cushing’s syndrome and is usually associated with resolution of the disease.Clinical Case: A 54-year old woman with central obesity (BMI 34.3 kg/m2), diabetes and hypertension had a left adrenal mass of 15 mm and characteristics suggestive of adenoma (Hounsfield unit of <10...