Searchable abstracts of presentations at key conferences in endocrinology

ea0013oc10 | Clinical and translational endocrinology | SFEBES2007

Expression of the orphan nuclear receptors oestrogen receptor related (ERR) alpha and beta in the human endometrium: implications for oestrogen receptor signalling

Bombail Vincent , MacPherson Sheila , Kerr Karen , McGarry Frances , Critchley Hilary , Saunders Philippa

Steroid receptors are members of a family of ligand-activated transcription factors that mediate tissue responses to a variety of endocrine stimuli. Using the human endometrium as a paradigm of a steroid responsive tissue, we aimed to characterise the expression and function of the oestrogen-receptor related orphan nuclear receptors (ERR) alpha and beta. ERRs share significant sequence homology with oestrogen receptors (ER) alpha and beta but are unable to bind oestradiol. The...

ea0013p233 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Co-cultures of pituitary lactotrophs and folliculostellate cells stimulates connexin 43 expression: a novel role for the nucleoside adenosine

Lewis Barbara , Francis Karen , Pexa Annette , Deussen Andreas , Scanlon Maurice , Rees Daffyd , Ham Jack

Folliculostellate (FS) cells within the anterior pituitary gland produce cytokines and growth factors which are regulated by molecules produced by neighbouring endocrine cells. There are many factors that could potentially be responsible for this intercellular communication that is mediated via connexins (Cx) and gap-junctions. We thus investigated the effect of co-culturing lactotrophs (MMQ) and FS cells (TtT/GF) on Cx43 expression. Our in vitro model system consists o...

ea0056p811 | Pituitary - Clinical | ECE2018

The diagnostic utility of late night salivary cortisol (LNSF) and cortisone (LNSE) in Cushing’s Syndrome and their relationship to metabolic markers

Garrahy Aoife , Forde Hannah , O'Kelly Patrick , McGurren Karen , Tormey William , Smith Diarmuid , Javadpour Mohsen , Agha Amar

The diagnosis of Cushing’s Syndrome (CS) requires demonstration of excess circulating cortisol. Measurement of late night salivary cortisol (LNSF) has been advocated as a simple, non-invasive and reliable outpatient diagnostic tool for patients with suspected CS but the usefulness of its metabolite cortisone (LNSE) remains unclear. LNSE levels are approximately six times higher than LNSF in saliva due to the rapid action of 11β-hydroxysteroid dehydrogenase type 2 (11...

ea0045oc7.3 | Oral Communications 7- Diabetes | BSPED2016

SEREN, (structured education: Reassuring empowering nurturing); a new structured education programme for diabetes in Wales, UK

Pryce Rebekah , D'Souza Nirupa , Baker Claire , Thomas Karen , Davies Yvonne , Reed-Screen Judith , Thomas Jayne

Background: Education in diabetes is a fundamental component of self-management. Health care systems that have structured education from diagnosis have demonstrated improving trends in HbA1c. Within Wales, education for Children and Young People (CYP) was delivered informally and this deficiency was highlighted in the National Paediatric Diabetes Audit. While structured education is being delivered in some parts of the UK, there is no overarching programme covering the entire ...

ea0045p58 | Miscellaneous/other | BSPED2016

Assessing impact of the provision of accessible information to families with Congenital Hyperinsulinism (CHI)

Trimarco Lauren , Banerjee Indi , Rigby Lindsey , Bowden Louise , Estebanez Maria Salomon , Cosgrove Karen , Nicholson Jacqueline

Introduction: Parents of children with complex diseases require easily understandable information about their disease to improve health outcomes. Improved disease understanding will also aid shared decision making between clinicians and families. Congenital hyperinsulinism (CHI) is a rare and complex disease of hypoglycaemia associated with significant neurodevelopmental morbidity for which online video-sharing information resources are available. The utility of such informati...

ea0094oc7.6 | Thyroid | SFEBES2023

Shallow whole genome sequencing (swgs) as an aiding tool in monitoring of thyroid cancer

Jumaah Ali Al , Levy Miles , Reddy Narendra , Allsopp Rebecca , Page Karen , Shaw Jacqui , Gohil Shailesh

Introduction: Liquid biopsies have revolutionised cancer care, from accurate diagnosis to guiding treatment and surveillance. Here, we used shallow Whole Genome Sequencing (sWGS); a cost-effective and easy-to-perform test to explore concordance of copy number alterations (CNAs) between formalin-fixed paraffin-embedded (FFPE) tissue extracted DNA and circulating cell-free DNA (cfDNA) in patients with Thyroid Cancer (TC) during different stages of the disease. <...

ea0094p206 | Metabolism, Obesity and Diabetes | SFEBES2023

New approaches to imaging metabolic heterogeneity in cultured adipocytes

Greig Justin , Tipping William , Graham Duncan , Faulds Karen , Cunningham Margaret , Gould Gwyn

Introduction: Adipocytes have been shown to exhibit considerable heterogeneity. In humans, they vary in size from <20 to 300 µm in diameter, which equates to a several hundred-fold difference in cell volume within the same tissue. Population based studies indicate larger adipocytes are associated with metabolic diseases, but how cell size is related to metabolism is poorly understood. Recent studies measured glucose levels in individual cells in cultu...

ea0094p91 | Neuroendocrinology and Pituitary | SFEBES2023

A novel AIP deletion emphasising the variable phenotype of AIP-related pituitary neuroendocrine tumours

Benjamin Loughrey Paul , J Morrison Patrick , K Ellis Peter , R Mullan Karen , Korbonits Marta

A 16-year-old female presented with secondary amenorrhoea. Menarche was age 14 years and periods were less frequent over the preceding 12 months. There was no galactorrhoea, headache or visual field disturbance and no known family history of pituitary disease, tall stature or infertility. There were no clinical signs of Cushing’s disease or acromegaly and visual fields were full to confrontation. Height was 160 cm. Investigations showed a prolactin of 2,452 mIU/l (RR 102-...

ea0095oc6.1 | Oral Communications 6 | BSPED2023

An audit on improving the endocrine management of patients with Duchenne Muscular Dystrophy

McKenna Martha , Stevenson Kim , Campbell Emma , Douglas Isobel , Thompson Karen , Abid Noina , Tirupathi Sandya

Introduction: Duchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disorder causing progressive muscular degeneration and weakness. The survival of patients with DMD has improved with multi-disciplinary team input. Sub-specialties have moved towards anticipatory diagnostic and therapeutic strategies which focus on prevention and treatment of modifiable disease complications. Endocrine complications of DMD include impaired growth, delayed pu...

ea0097006 | Section | BES2023

Effects of Long-term Testosterone Treatment in Transgender People without Gender-Affirming Surgery: the ELANTES study

Karen Decaestecker , Jeroen Vervalcke , Visschere Pieter De , Steven Weyers , Guy T'Sjoen

Background: Since pelvic gender-affirming surgery (GAS) is no longer required for legal gender change, we expect a growing number of transgender men and gender nonbinary people who refrain from pelvic surgery. Little is known about the effects of long-term testosterone use on the reproductive organs. Polycystic ovaries and endometrial changes have been described in previous histology-based studies. Furthermore, cervical cancer screening (CCS) is still recommen...