Searchable abstracts of presentations at key conferences in endocrinology

ea0013p117 | Comparative | SFEBES2007

Performance characteristics of an intact PTH recently developed for the Abbott Architect immunoassay analyser

Smith Karen , Wallace Mike , Louden Ian

Concerns on the noncomparibility of intact parathyroid hormone (iPTH) methods have recently been voiced (Cantor T et al; Clin Chem 2006, 52, 1771–6). It is therefore important that any new iPTH immunoassays are thoroughly validated before routine use. We describe performance characteristics for an iPTH immunoassay on the ARCHITECT 8200i analyser as compared with iPTH measurement on the Diasorin LIAISON platform. Potassium EDTA plasma samples (n=80) we...

ea0013p262 | Reproduction | SFEBES2007

IGFBP-3 has both IGF-dependent and –independent effects on cytotrophoblast proliferation in the human placenta

Forbes Karen , Aplin John D , Westwood Melissa

IGF-I and -II influence cytotrophoblast proliferation by activating the type-I IGF receptor (IGF1R) in first trimester human placenta. Ligand access to receptors is regulated by IGF binding proteins (IGFBPs) 1-6. In humans, the most abundant IGFBPs at the maternal-fetal interface are IGFBP-1 and IGFBP-3; we hypothesised that these IGFBPs function to regulate the effects of IGFs in the placenta and used our placental explant model, in which proliferation and differentiation are...

ea0013p280 | Steroids | SFEBES2007

Subclinical Addison’s disease

Hughes Katherine , Sandeep Thekkepat , Adamson Karen

A young female presented concerned that she may have Addison’s disease. She had noted increasing pigmentation and reported her sister had died from undiagnosed Addison’s disease. She was hypotensive, with no postural drop in her blood pressure. She was hyponatraemic and hyperkalaemic. An initial 250 μg Synacthen test performed in the afternoon gave a baseline cortisol of 258 nmol/L and a 30 minute cortisol of 291 nmol/L. In view of this, the Synacthen test was r...

ea0056p267 | Clinical case reports - Thyroid/Others | ECE2018

Lithium-associated Hyperparathyroidism in a Filipino woman presenting as recurrent ischemic stroke: a case report

Francisco Danica , Lazaro Karen , Puno-Ramos Patricia

Background: Lithium salts have been widely known to induce thyroid dysfunction, however, parathyroid dysfunction due to lithium use is uncommonly encountered. Hypercalcemia is a relatively common consequence of lithium therapy presenting with nonspecific symptoms that may be overlooked. Although cerebral infarction may be an independent event from psychiatric disorders, it can also be a rare complication that must be recognized particularly in patients on lithium therapy.<...

ea0073aep730 | Thyroid | ECE2021

Intravenous thyroxine administration in hospitalized patients, a common but unreported practice: A single institution recent experience

Tordjman Karen , Bishouty Nancy , Greenman Yona

BackgroundIntravenous levothyroxine (IVT4) is FDA-approved for the treatment of myxedema coma (ME). We noticed that at our hospital, IVT4 is administered more frequently than expected.Aim of studyTo assess the extent of IVT4 administration, the indications for such a treatment, and its outcome at a tertiary facility.MethodsA retrospective study of IVT4 administere...

ea0092ps3-21-04 | Hypothyroidism | ETA2023

Autoimmune thyroid disease and hypothyroidism in patients with iron deficiency

Ghasaboghlyan Mari , Petrosyan Karen , Sanamyan Armine

Background: Autoimmune thyroid diseases (AITD) are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency (ID) is considered to be the most common nutritional deficiency worldwide and has multiple effects on thyroid metabolism.Aim: The goal of this study is to measure the prevalence of auto...

ea0094p2 | Adrenal and Cardiovascular | SFEBES2023

Comparison of aldosterone measurements during saline suppression tests by immunoassay and liquid chromatography tandem mass spectrometry methods

Frank Amy , Johnston Susan , Smith Karen

Background: Primary aldosteronism is an increasingly recognised cause of hypertension, caused by excess aldosterone secretion. Screening and confirmatory tests such as saline suppression tests (SST) require accurate measurements of aldosterone and use of appropriate cut-offs. Many laboratories have chosen liquid chromatography tandem mass spectrometry (LC-MSMS) methods as issues of poor specificity have been reported for immunoassay methods. During the validat...

ea0094p285 | Thyroid | SFEBES2023

Dietary and supplemental iodine intake in a cohort of pregnant women in Northern Ireland

Kayes Lucy , Mullan Karen , Woodside Jayne

Since the 1990’s, eight survey studies have demonstrated iodine deficiency during pregnancy across the UK and Ireland. Both countries lack an iodine fortification programme, unlike many European countries. Therefore, women must rely on dietary adjustments and supplementation to achieve the iodine intake required in pregnancy. The World Health Organisation (WHO) recommends an increase from 150 to 250 µg/day during pregnancy. Pregnant women in Belfast were recruited to...

ea0099p144 | Reproductive and Developmental Endocrinology | ECE2024

Adopted transgender subjects are over represented and have a different psychosocial profile than their non-adopted counterparts: a case-control study

Yaish Iris , Greenman Yona , Tordjman Karen

Background and Aim: We previously demonstrated (1) that in our transgender clinic, adoptees are significantly overrepresented compared to the general population, suggesting early life traumas may play a role in the etiology of transgenderism. We had also shown a large preponderance (close to 80%) of female sex-assigned-at-birth (SAB), and a trend for presenting for treatment at an older age than non-adopted subjects. In the current study we aimed to further characterize this s...