Endocrine Abstracts

The cardiac effects of subclinical hypothyroidism (SCH i.e. increased circulating TSH with normal T4) have been documented. While overt hypothyroidism causes increased central arterial stiffness (CAS) and augmentation gradient (AI) 1, there are only limited data in SCH. We have measured CAS, AG and augmentation Index (AI) (AG/Pulse pressure x 100) in patients with SCH before and after L-thyroxine (synthroid) therapy.Peripheral pulse pressure w...

A 49 year old lady was referred to the endocrine clinic for investigation of intermittent hyponatremia. She had two admissions in the year with lower abdominal, back pain and dark urine and treated for urinary infections.Serum sodium was 112,114 millimoles per litre, which responded to fluid restriction.She had a past history of syncopal episodes, hypertension treated with atenolol, amlodipine. She was a nonsmoker, alcohol intake was 14 units per week.</...

This 42-year-old male presented with a six-month history of general lethargy and mood changes. He had experienced weakness & difficulty climbing stairs; weight loss; ankle swelling and increased frequency of micturition. There was no significant past medical history.Initial investigations revealed Na+ 144mmol/L (135-145);K+ 2.3mmol/L(3.5-5.2); U 8.8mmol/L (2.6-6.7); Cr 75μmol/L (60-125); TCO2 41mmol/L (21-31); Fasting glucose 7.4mmol/L; TSH 0.21mU...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...

Thyroid nodule is a potential thyroid cancer and hence prompt assessment of all cases is mandatory. Fine needle aspiration (FNA) is a simple and reliable test in the management of thyroid nodule.This is a prospective audit of all new patients with thyroid nodules referred to our endocrine unit in the period between November 2000 to March 2002. 64 patients were identified, 57(89%) of which were females. The mean average age was 49. Thyroid function test w...

This 42-year-old male presented with a six-month history of general lethargy and mood changes. He had experienced weakness & difficulty climbing stairs; weight loss; ankle swelling and increased frequency of micturition. There was no significant past medical history.Initial investigations revealed Na+ 144mmol/L (135-145);K+ 2.3mmol/L(3.5-5.2); U 8.8mmol/L (2.6-6.7); Cr 75μmol/L (60-125); TCO2 41mmol/L (21-31); Fasting glucose 7.4mmol/L; TSH 0.21mU...

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...

A 36 year old lady presented with a 6 month history of amenorrhoea & increasing fatigue. There was no background of headaches or visual disturbance. She denied thyroid related symptoms. Examination revealed her to be both pale and fatigued however there were no other significant findings. Investigations revealed: random cortisol 56 nmol/l; prolactin 1698mU/l (0-480); LH 0.3U/l; FSH 2.9U/l; fT4 <5pmol/l (10-24); TSH 21.92mU/l (0.4-4.0); IGF1 12.5nmol/l (10-24) An insulin...

Case Report:A 69 year old man was referred for assessment of hypoglycaemic events. Type 2 diabetes was diagnosed 4 years previously and treatment with metformin 2000mg per day had provided adequate control (HbA1c 7.5%). In the 4 months prior to referral, the patient had lost 8kg in weight and had had more than 10 episodes of sweating, tremor and disorientation. Eventually capillary blood glucose measurements were undertaken which suggested hypoglycaemia which was confirmed...

This research is a descriptive and analytic study which was carried out to investigate the Fasting Blood Sugar of first trimester and 24-28 weeks , and 50-gram Glucose Challenge Test at 24-28 weeks of gestational age in non-diabetic pregnant women and their effect on the infants' weight in Shariati Hospital in Tehran .The means of the Fasting Blood Sugar for the first trimester , 24-28 weaks and Glucose Challenge Test were 81.15 , 80.8 and 111.75 miligrams per deciliter re...