Searchable abstracts of presentations at key conferences in endocrinology

ea0029p46 | Adrenal cortex | ICEECE2012

Differential methylation signature in benign and malignant cortisol producing adrenocortical tumors

Akerstrom T. , Ahmad T. , Hellman P. , Bjorklund P.

Background: Adrenocortical carcinomas (ACC) are rare tumors with an incidence of 1–2 per million. Although rare, it is an aggressive endocrine cancer with poor prognosis. As of today there is no reliable diagnostic biomarker to distinguish benign tumors from malignant tumors. Global changes in DNA methylation and DNA promoter hypermethylation are important events in tumorigenesis. Promoter hypermethylation can cause silencing of tumour suppressor genes or lead to abnormal...

ea0029p133 | Bone & Osteoporosis | ICEECE2012

De novo autoimmune hepatitis associated with PTH(1–34) and PTH(1–84) administration for severe osteoporosis in a liver transplant patient

Anagnostis P. , Efstathiadou Z. , Akriviadis E. , Hytiroglou P. , Kita M.

Introduction: Recombinant parathyroid hormone 1–34 (PTH(1–34)) and 1–84 (PTH(1–84)) stimulate new bone formation and are associated with significant decrease in the risk of vertebral and non-vertebral fractures. De novo autoimmune hepatitis (AIH) is a rare graft dysfunction occurring in patients having undergone liver transplantation (LT) for causes other than AIH.Case report: A 61-year old woman was referred to our metabolic b...

ea0029p185 | Bone & Osteoporosis | ICEECE2012

Cimetidine (histamine H2-receptor antagonist and antiandrogenic drug) exerts a beneficial effect in the injured tissues by periodontal disease in male rat molars

Longhini R. , de Oliveira P. , Sasso-Cerri E. , Cerri P.

Studies have demonstrated the presence of androgen receptors in osteoblasts and osteocytes, confirming that androgens are important for the maintenance of bone in men. Additionally to steroid hormones, histamine stimulates osteoclast differentiation and survival and plays a role in the inflammatory response via H2 receptors. We purposed to investigate whether cimetidine, an histamine H2 receptors antagonist and antiandrogenic drug, interferes in the periodontal tissue damages ...

ea0029p888 | Female Reproduction | ICEECE2012

An invdup (15) associated with premature ovarian insufficiency

Viola D. , Valetto A. , Bertini V. , Simi P. , Vitti P.

Premature ovarian insufficiency (POI) is a disorder in which amenorrhea, associated to elevated levels of gonadotropins, occurs before the age of 40 years.The proband, a 36-year-old woman, was born at term after an uneventful pregnancy and delivery from healthy non-consanguineous parents. Growth and mental developmental milestones were normal. At the age of 12 years she presented menarche followed by regular menses, she had no miscarriage and had a succe...

ea0029p1437 | Pituitary Clinical | ICEECE2012

Efficacy of transsphenoidal surgery for Cushing’s disease: the role of combined dexamethasone desmopressin test

Witek P. , Glinicki P. , Szamotulska K. , Zielinski G.

Introduction: The treatment of choice in Cushing’s disease (CD) is transsphenoidal surgery (TSS). The success of surgical procedure is of particular importance in terms of patient`s prognosis. The aim of this study was the prospective evaluation of compatibility of coupled 1 mg dexamethasone suppression test and 10 μg desmopressin stimulation test (CDDT) with standard criteria of remission in CD.Methods: The study population consisted of 36 pat...

ea0029p1655 | Thyroid (non-cancer) | ICEECE2012

Left-shifted set point of calcium/PTH-relation in patients with Grave’s thyrotoxicosis

Annerbo M. , Stalberg P. , Hultin H. , Hellman P.

Patients with Grave’s disease (GD) are more prone to develop low serum calcium values than patients operated on because of goitre after total thyroidectomy. Moreover, some patients with GD achieve hypercalcemia probably due to active bone disease. We have used citrate-calcium clamping (CiCa) in order to investigate the calcium homeostasis in detail in patients with Grave’s disease.Material and method: Our series of patients undergoing total thy...

ea0026p48 | Endocrine disruptors | ECE2011

The role of progestins in the interplay of estradiol and genistein: influences on the steroid hormone receptor expression patterns in distinct uterine compartments

Moller F , Honschied P , Zierau O , Diel P , Vollmer G

Ovariectomized (OVX) rats are commonly used for the investigation of estrogenic compounds in vivo. We previously showed that estrogen treated OVX animals apparently respond differently to Genistein (GEN) treatment than hormonally intact animals. An observation, that indicated that progestins might interfere in the estradiol (E2)–GEN interaction.As the molecular effects of GEN seem to be modified by progesterone (P4), its...

ea0026p54 | Endocrine tumours and neoplasia | ECE2011

Frequency, localisation of unusual metastases of medullary thyroid cancer and impact on survival: an observational study in 102 patients

Criniere L , Pierre P , Baudin E , Guyetant S , Lecomte P

Medullary thyroid carcinoma (MTC) early spreads to cervical lymph nodes and to distant sites: mostly to the liver, lungs or bones. Unusual sites such as breast, skin or orbit have been also described. The aim of the study was to evaluate the frequency, localisation of unusual metastases of MTC and their impact on survival.Eligibility criteria for this study were the presence of a pathological confirmed diagnosis of MTC with distant metastases (other than...

ea0026p684 | Diabetes therapy | ECE2011

Impact of structured testing on level of glycemic control

Popovic-Pejicic S P P , Karlovic V K

Introduction: Clinical trials have show n that improved glycemic control reduces the incidence and progression of diabetes complications. One of the most important steps in diabetes treatment is to educate patients how to manage self monitorining blood glucose (SBGM) and adjust their life habits with their diabetes. A new diabetes management concept of structured testing is supported by Accu -Chek 360 View.Objectives: Assess the impact of structured test...

ea0024p35 | (1) | BSPED2010

NAFLD in type 1 DM: a report of 2 cases

Kumar P , Ghatak A , Blair J C , Didi M , Paul P

Introduction: Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver disease (NAFLD). NASH commonly occurs in patients with type 2 DM and is less recognised in type 1 DM. The natural history of NASH in adult patients suggests potential development of progressive fibrosis and cirrhosis. However, secondary glycogenosis, commonly occurs in type 1 DM, is reversible when good glycaemic control is achieved, but may be misidentified as NASH b...