Endocrine Abstracts

Primary aldosteronism has recently been found as a common cause for essential or secondary hypertension. As much as 1/10 may be explained by this disease. Diagnosis is crucial, since a adrenalectomy may cure the patient.The underlying cause in the majority of sporadic cases have been unknown until recently, while classically three forms of familial hyperadlosteronism (FH) exist: familial hypertension type I, II and III.FHI, which o...

The widespread use of abdominal CT/ MRI has resulted in a new and common diagnosis for the clinical endocrinologist – the management of patients with adrenal incidentalomas. Defined as an adrenal mass discovered incidentally in the work-up or treatment of clinical conditions not related to suspicion of adrenal disease, incidentalomas cover a spectrum of underlying adrenal pathologies with a common pathway of discovery. Because of the risk of malignancy, they raise uncerta...

The endoscopic endonasal approach, initially reserved only for sellar lesions, is a continuous evolving speciality of modern neurosurgery, which requires precise anatomical knowledge, technical skills and integrated appreciation of the pathology dealt with. Nowadays, it represents a minimally invasive approach to deal with several diseases interesting mostly the entire skull base – namely the suprasellar, retrosellar and parasellar spaces – obviating brain retraction...

Graves’ disease is a common autoimmune disorder with autoimmunity against the TSH-receptor being a central pathogenetic element. The disease may present with a number of clinical manifestations, among which hyperthyroidism caused by TSH-receptor stimulating antibodies is the most prevalent. The disease is common in all adult ages and affects women 4–5 times more often than men.In many countries the preferred initial therapy of the hyperthyroidi...

Background: Vitamin D insufficiency (VDI) was reported to be associated with decreased insulin sensitivity (IS). Individuals with higher osteocalcin (OC) were shown to have better IS. Vitamin D regulates OC synthesis. Obese children carry an abnormal glucose homeostasis risk. Whether correction of VDI improves IS in obese children and mediates such effect via OC are unclear. We, therefore, studied glucose homeostasis, IS, vitamin D status and serum OC concentration in 230 obes...

Objective: The concentration of GH (hGH) is important in the attribution of hGH therapy, for which in The Netherlands a national committee is responsible. Without this authorization re-imbursement is impossible. Therapy is permitted if all hGH concentrations after two stimulation tests are below 20 mU/l and in some clinical conditions independent of hGH. However, different assays produce different results and nationwide hGH results varied with CV ~30%. Consequently, authorizat...

Background: The most common psychiatric syndromes in thyrotoxicosis are anxiety and mood disturbances. Psychosis, however, is a rare complication. Here is a report of such a case.Case report: A twenty-six year old female presented with a 13 year history of palpitations, easy fatigability and anterior neck mass. Patient denies any comorbid conditions. No family history of psychiatric illness. On March 2011, she was admitted due to logorrhea, auditory hall...

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Vitamin D deficiency is more common in pregnant women than in non-pregnant women of similar age. Clinical vitamin D deficiency, associated with rickets and osteomalacia, may occur when serum 25-hydroxyvitamin D (25(OH)D) is lower than 25 nmol/l. The required serum 25(OH)D is currently set at 50 nmol/l, as lower levels are associated with lower bone mineral density, increased fracture risk and other outcomes such as lower physical performance than a vitamin D adequate state, i....