Endocrine Abstracts

Background: Phase angle (PA) is defined as the angular displacement between the current and voltage waveforms due to capacitor interference, measured in degrees or radians. [1] The fat-free mass (FFM) is made up of water and electrolytes and is characterized by a low impedance, while the FM (fat mass) is water-free and, therefore, with a high impedance. The larger the FM, the higher the resistance, and this parameter affects the PA. Body mass index (BMI) is the most widely use...

Background: As a trace element selenium (Se) is essential for man and animals, in particular for the maintenance of spermatogenesis and male fertility. A growing number of evidence shows that Se is necessary for testosterone synthesis, and inappropriate concentration, Se can stimulate Leydig cell proliferation. However, Se can also act as a metalloestrogen, which can mimic estrogen and activate the estrogen receptors. In higher concentrations, Se might have an adverse effect o...

Introduction: The true prevalence of clinically relevant pituitary adenomas has been reevaluated at 1/1064 of the population (1). Among them, prolactinomas represent the majority with a prevalence of 1/2000. They occur usually in females, aged 20–50 Y.O., and 80% are microadenomas. Nearly 5% of prolactinomas appear in a familial or genetic setting (MEN-1 or FIPA) (2). Cabergoline is proposed as the first line therapy and is usually efficient to normalize prolactin (PRL) l...

Immune checkpoints inhibitors have fundamentally changed the management of oncologic patients. These treatments consist of monoclonal antibodies directed against CTLA-4 (cytotoxic T-lymphocyte antigen 4), PD-1 (programmed cell death protein-1) and PD-L1 (one of its ligands). By blocking these receptors or ligands, the antibodies reverse the immune tolerance induced by the cancerous cell on the T-lymphocyte and favour lymphocytic reactivation and anti-tumor activity. Immune tol...

A 43-year-old roman, previously living in France was referred to the endocrinology department for Hashimoto’s hypothyroidism in 2017. Thyroid function was easily normalized by a treatment by thyroxine. She had also a medical history of severe alopecia since the age of 20. The diagnosis of androgenetic alopecia was made at that time by a French dermatologist and treatment by estradiol valerate 2 mg with cyproterone acetate (CPA) 50 mg was started. The dose of CPA was lower...

Case: A 42-year old woman was referred to the endocrinology department for polydipsia and polyuria of sudden onset one month prior to presentation. She drank between 8 and 10 litres of water per day and complained of thirst, asthenia and lighter menstruation under her usual oral contraceptive pill. In addition to contraception she took 50 μg of L-thyroxine for Hashimoto thyroïditis. She had also a medical history of pink-red cutaneous lesions evolving for more than 1...

Background: Endocrinology is a relatively young subspecialty of internal medicine. No consensus on international standards for training has been established, and hence the variability between training programs and endocrinologist qualifications may be great.Methods: A standardized questionnaire was constructed to explore individual national standards for endocrinology training, evaluating the responding programs for physician entry criteria for each prog...

Objectives: Copper-64 (64Cu, T1/2=12.7 h; Eβ+ max =0.65 MeV (17.9%); Eβ− max =0.57 MeV (39%)) is suitable for in-vivo PET imaging. Prostate specific membrane antigen (PSMA) is significantly over-expressed in undifferentiated prostate cancer tissue. We report the initial molecular imaging results with 64Cu-PSMA PET/CT in patients with prostate cancer.Methods: 64Cu labeled PSMA (mean administered ra...

Clinical Endocrinology 2015 82 136–141. DOI: 10.1111/cen.12559...

Introduction: Hartsfield syndrome (#OMIM 615465) describes the rare co-occurrence of holoprosencephaly with ectrodactyly, associated with a spectrum of developmental defects including specific pituitary dysfunction.Case report: Our patient, a male infant, had several congenital abnormalities: bilateral cleft lip and palate, right sided microtia, bilateral ectrodactyly of the hands and feet and semilobar holoprosencephaly. Aged 5 weeks he was noted to be ...