Endocrine Abstracts

Introduction: The role of dietary protein in maintaining bone health is controversial. Traditionally the acidifying effect of high dietary protein (HP) has been thought to promote calcium loss from bone and hence hypercalciuria and so was considered harmful compared to a normal protein (NP) diet. However more recently the anabolic effect of increased dietary protein and its effect in increasing calcium absorption have been appreciated. There are no long term prospective clinic...

Introduction: Cushing’s syndrome caused by adrenocorticotropic hormone-producing pheochromocytoma has been rarely reported. In such cases, the high production of ectopic adrenocorticotropic hormone produced by pheochromocytoma results in bilateral adrenocortical hyperplasia and thus in consecutive Cushing’s syndrome. We report a case of a 43-year-old patient with a 6 cm right-sided adrenal tumor producing both elevated levels of catecholamines and adrenocorticotropic...

Introduction: Current treatment for SIADH related hyponatremia is unsatisfactory. We describe two cases of effective Tolvaptan use in SIADH related to disseminated cancer.Case 1: Fifty-three year old female with metastatic ovarian carcinoma, vomiting from partial intestinal obstruction, was referred with sodium 121 mmol and normal renal function. She was clinically dry and mildly confused. SIADH was confirmed but urine Na was <10 suggestive of hypovo...

Introduction: The association between type 2 diabetes mellitus and obesity is very close. Obesity is common in women aged between 45 and 49 years. Prevalence of prediabetes, i.e. impaired fasting glucose also seems to be higher in women than men in the Indian population. The present work is planned to study the prediabetic status in preobese and obese in pre- and post-menopausal women with the help of estimation of fasting blood glucose (FBG) levels.Mate...

There is a strong correlation between metabolic status (e.g. obesity, diabetes, alcohol use and abuse) and reproductive functions. Disruptions of metabolic status affecting the reproductive system are often manifested as decrease in secretion of hormone (GnRH) and (LH), disruptions of secretion of sex steroids and estrus cycles (in animals) or menstrual cycles (in women), and may even lead to infertility. Diabetes and obesity are also correlated with hypogondism, which is repo...

Autophagy is a catabolic process that promotes hepatic cell survival during starvation and metabolic stress. Currently, little is known about the endocrine regulation of autophagy. Recent studies by Singh et al. (Nature 458, 1131–1135 (2009)) showed a critical link between autophagy and beta oxidation in hepatocytes. Accordingly, we examined whether hormones known to promote beta oxidation of fatty acids also stimulated autophagy in hepatic cells. Surprisingly, we found t...

Introduction: Both subclinical hyperthyroidism and type 2 diabetes (T2D) have been associated with an increase in cardiovascular disease risk and mortality. We aimed to assess the prevalence of newly diagnosed subclinical hyperthyroidism in a cohort of patients with T2D, and also to analyse the relationships between diabetes-related characteristics and the presence of subclinical hyperthyroidism.Methods: Nine hundred and thirty-three diabetic patients wi...

Objectives: Thyroglobulin (Tg) play an important role in managements of well-differentiated thyroid carcinoma (DTC). Undetectable TSH-stimulated serum Tg level in the absence of antithyroglobulin antibody (AbTg) indicates complete remission. Circulating AbTg may interfere with Tg assay and may cause false negative results. Moreover, undetectable Tg is observed in a part of patients after total thyroidectomy(TT), even if serum AbTg concentration is low.Th...

The circulating levels of serum TSH and thyroid hormones represent biochemical phenotypes reflecting thyroid homeostasis. Studying the regulation of biochemical measures related to the thyroid in healthy individuals could prove essential in understanding the pathways that eventually lead to thyroid disease. It is the combined effect of genetic and environmental factors that give rise to these endophenotypes. It has been established that the measures reflecting thyroid homeosta...

Giant prolactinomas are rare and their treatment and outcome has been addressed only in isolated case reports. Some patients develop treatment-resistant tumors. We describe a patient with an invasive PRLoma resistant to conventional therapy. A 40-year-old female was diagnosed at age 22 a PRLoma who, although having received all available formulations of dopamine agonists over a period of 18 years, responded neither clinically, nor hormonally (PRL 9560.0 ng/ml, nv <20). At ...